• Official Full Name

    interleukin 17 receptor E

  • Background

    This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
  • Synonyms

    IL17RE; interleukin 17 receptor E; interleukin-17 receptor E; IL-17 receptor E;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL17RE-14161H Recombinant Human IL17RE, GST-tagged E.coli GST
    Human IL17RE-1630H Recombinant Human IL17RE protein, Fc-tagged HEK293 Fc
    Mouse IL17RE-8129M Recombinant Mouse IL17RE Protein Mammalian Cell His
    Mouse Il17re-7981M Recombinant Mouse Il17re protein, His-tagged E.coli His
    Mouse IL17RE-4501M Recombinant Mouse IL17RE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse IL17RE-4501M-B Recombinant Mouse IL17RE Protein Pre-coupled Magnetic Beads HEK293
    Rat Il17re-7982R Recombinant Rat Il17re protein, His-tagged E.coli His
    Rat IL17RE-2685R Recombinant Rat IL17RE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat IL17RE-2685R-B Recombinant Rat IL17RE Protein Pre-coupled Magnetic Beads HEK293
    Rat IL17RE-3030R Recombinant Rat IL17RE Protein Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL17RE Related Articles
    • IL17RE Related Research Area

    IL17RE involved in several pathways and played different roles in them. We selected most pathways IL17RE participated on our site, such as IL17 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17RE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IL17 signaling pathwayTRAF3IP2;IL17RC;IL17RE;IL17C;IL17F

    IL17RE has several biochemical functions, for example, interleukin-17 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17RE itself. We selected most functions IL17RE had, and list some proteins which have the same functions with IL17RE. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-17 receptor activityIL17RE;IL17RB;IL17RD;IL17RA;IL17RC
    protein bindingVAMP3;S1PR2;FAM184A;ZNF224;MYOC;PDIA3;TIFA;NLRC4;SH3GL3

    IL17RE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17RE here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17RE.


    Elain, G; Jeanneau, K; et al. The Selective Anti-IL17A Monoclonal Antibody Secukinumab ( AIN457) Attenuates IL17A-Induced Levels of IL6 in Human Astrocytes. GLIA 62:725-735(2014).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How do researchers study the potential therapeutic applications of targeting IL17RE in the context of immune-related conditions? 06/28/2022

    Therapeutic antibody development, in vivo efficacy studies, and disease models explore IL17RE as a potential target for immune-related therapies.

    How are insights gained from experimental studies on IL17RE integrated into translational research to advance our understanding of its clinical relevance? 05/24/2022

    Clinical studies, biomarker validation, and patient stratification efforts connect IL17RE's experimental findings to its clinical implications.

    How are molecular and structural biology approaches utilized to understand the binding interfaces and conformational changes of IL17RE in complex with its ligands? 05/20/2022

    X-ray crystallography, cryo-electron microscopy, and molecular modeling provide insights into IL17RE's ligand recognition and conformational changes.

    Can you elaborate on the techniques used to investigate IL17RE's tissue-specific expression patterns and its regulation under various physiological conditions? 11/24/2021

    Transcriptomics, immunohistochemistry, and in vitro culture systems explore IL17RE's expression patterns and responses to diverse stimuli.

    How do researchers experimentally differentiate IL17RE's roles within the IL17 receptor family and its potential crosstalk with other family members? 07/12/2021

    Comparative functional assays, co-stimulation studies, and knockout models help discern IL17RE's distinct contributions and receptor interactions.

    Could you explain the methodologies researchers use to assess the impact of IL17RE on immune cell differentiation, cytokine production, and immune responses? 12/28/2020

    Flow cytometry, cytokine assays, and immune cell co-culture models assess IL17RE's impact on immune cell functions and cytokine production.

    What experimental strategies are employed to identify the ligands or signaling molecules that interact with IL17RE and contribute to downstream signaling? 10/06/2019

    Ligand-receptor interaction assays, proteomic analyses, and mutational studies identify IL17RE's binding partners and downstream effectors.

    What animal models, genetic manipulation techniques, and in vivo assays are used to elucidate IL17RE's physiological functions and its involvement in diseases? 08/26/2019

    Knockout mice, CRISPR-mediated gene editing, and adoptive transfer experiments unravel IL17RE's roles in vivo and its contributions to diseases.

    What cellular assays and functional readouts are used to dissect the intracellular signaling pathways triggered by IL17RE activation and their implications? 08/19/2018

    Phosphorylation assays, luciferase reporter systems, and cytokine profiling dissect IL17RE-mediated signaling cascades and immune outcomes.

    What experimental methods are employed to investigate the potential role of IL17RE in the pathogenesis of autoimmune diseases or inflammatory disorders? 04/14/2018

    Patient samples, disease models, and in vitro inflammation models probe IL17RE's involvement in autoimmune and inflammatory pathogenesis.

    Customer Reviews (3)

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      Effective in T-cell activation. -


        High specificity. -


          Suitable for ELISA. -

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