Recombinant Rat IL17RE Protein, His (Fc)-Avi-tagged

• Cat.No.: IL17RE-2685R
• Product Overview: Recombinant Rat IL17RE with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Il17re interleukin 17 receptor E [ Rattus norvegicus ]
• Official Symbol: IL17RE
• Gene ID: 362417
• mRNA Refseq: NM_001004091.1
• Protein Refseq: NP_001004091.1
• UniProt ID: Q6AZ51

Reviews

02/20/2022

Effective in T-cell activation.

03/18/2021

High specificity.

08/11/2018

Suitable for ELISA.

Q&As

How do researchers study the potential therapeutic applications of targeting IL17RE in the context of immune-related conditions?

Therapeutic antibody development, in vivo efficacy studies, and disease models explore IL17RE as a potential target for immune-related therapies.

How are insights gained from experimental studies on IL17RE integrated into translational research to advance our understanding of its clinical relevance?

Clinical studies, biomarker validation, and patient stratification efforts connect IL17RE's experimental findings to its clinical implications.

How are molecular and structural biology approaches utilized to understand the binding interfaces and conformational changes of IL17RE in complex with its ligands?

X-ray crystallography, cryo-electron microscopy, and molecular modeling provide insights into IL17RE's ligand recognition and conformational changes.

Can you elaborate on the techniques used to investigate IL17RE's tissue-specific expression patterns and its regulation under various physiological conditions?

Transcriptomics, immunohistochemistry, and in vitro culture systems explore IL17RE's expression patterns and responses to diverse stimuli.

How do researchers experimentally differentiate IL17RE's roles within the IL17 receptor family and its potential crosstalk with other family members?

Comparative functional assays, co-stimulation studies, and knockout models help discern IL17RE's distinct contributions and receptor interactions.

Could you explain the methodologies researchers use to assess the impact of IL17RE on immune cell differentiation, cytokine production, and immune responses?

Flow cytometry, cytokine assays, and immune cell co-culture models assess IL17RE's impact on immune cell functions and cytokine production.

What experimental strategies are employed to identify the ligands or signaling molecules that interact with IL17RE and contribute to downstream signaling?

Ligand-receptor interaction assays, proteomic analyses, and mutational studies identify IL17RE's binding partners and downstream effectors.

What animal models, genetic manipulation techniques, and in vivo assays are used to elucidate IL17RE's physiological functions and its involvement in diseases?

Knockout mice, CRISPR-mediated gene editing, and adoptive transfer experiments unravel IL17RE's roles in vivo and its contributions to diseases.

What cellular assays and functional readouts are used to dissect the intracellular signaling pathways triggered by IL17RE activation and their implications?

Phosphorylation assays, luciferase reporter systems, and cytokine profiling dissect IL17RE-mediated signaling cascades and immune outcomes.

What experimental methods are employed to investigate the potential role of IL17RE in the pathogenesis of autoimmune diseases or inflammatory disorders?

Patient samples, disease models, and in vitro inflammation models probe IL17RE's involvement in autoimmune and inflammatory pathogenesis.