Active Recombinant Human IL17RE protein, Fc-tagged

Cat.No. : IL17RE-1630H
Product Overview : Recombinant Human IL17RE protein(Thr155-His454), fused with Fc tag, was expressed in HEK293.
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  • Gene Information
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Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5.
Bio-activity : Immobilized Human IL-17C, His Tag at 2 μg/mL (100 μL/well) can bind Human IL-17 RE (155-454), Fc Tag with a linear range of 1-10 ng/mL.
Molecular Mass : This protein carries a human IgG1 Fc tag at the C-terminus.The protein has a calculated MW of 60.5 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Proteinlength : Thr155-His454
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IL17RE interleukin 17 receptor E [ Homo sapiens ]
Official Symbol : IL17RE
Synonyms : IL17RE; interleukin 17 receptor E; interleukin-17 receptor E; FLJ23658; IL-17 receptor E; MGC71884;
Gene ID : 132014
mRNA Refseq : NM_001193380
Protein Refseq : NP_001180309
UniProt ID : Q8NFR9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How do researchers study the potential therapeutic applications of targeting IL17RE in the context of immune-related conditions? 06/28/2022

Therapeutic antibody development, in vivo efficacy studies, and disease models explore IL17RE as a potential target for immune-related therapies.

How are insights gained from experimental studies on IL17RE integrated into translational research to advance our understanding of its clinical relevance? 05/24/2022

Clinical studies, biomarker validation, and patient stratification efforts connect IL17RE's experimental findings to its clinical implications.

How are molecular and structural biology approaches utilized to understand the binding interfaces and conformational changes of IL17RE in complex with its ligands? 05/20/2022

X-ray crystallography, cryo-electron microscopy, and molecular modeling provide insights into IL17RE's ligand recognition and conformational changes.

Can you elaborate on the techniques used to investigate IL17RE's tissue-specific expression patterns and its regulation under various physiological conditions? 11/24/2021

Transcriptomics, immunohistochemistry, and in vitro culture systems explore IL17RE's expression patterns and responses to diverse stimuli.

How do researchers experimentally differentiate IL17RE's roles within the IL17 receptor family and its potential crosstalk with other family members? 07/12/2021

Comparative functional assays, co-stimulation studies, and knockout models help discern IL17RE's distinct contributions and receptor interactions.

Could you explain the methodologies researchers use to assess the impact of IL17RE on immune cell differentiation, cytokine production, and immune responses? 12/28/2020

Flow cytometry, cytokine assays, and immune cell co-culture models assess IL17RE's impact on immune cell functions and cytokine production.

What experimental strategies are employed to identify the ligands or signaling molecules that interact with IL17RE and contribute to downstream signaling? 10/06/2019

Ligand-receptor interaction assays, proteomic analyses, and mutational studies identify IL17RE's binding partners and downstream effectors.

What animal models, genetic manipulation techniques, and in vivo assays are used to elucidate IL17RE's physiological functions and its involvement in diseases? 08/26/2019

Knockout mice, CRISPR-mediated gene editing, and adoptive transfer experiments unravel IL17RE's roles in vivo and its contributions to diseases.

What cellular assays and functional readouts are used to dissect the intracellular signaling pathways triggered by IL17RE activation and their implications? 08/19/2018

Phosphorylation assays, luciferase reporter systems, and cytokine profiling dissect IL17RE-mediated signaling cascades and immune outcomes.

What experimental methods are employed to investigate the potential role of IL17RE in the pathogenesis of autoimmune diseases or inflammatory disorders? 04/14/2018

Patient samples, disease models, and in vitro inflammation models probe IL17RE's involvement in autoimmune and inflammatory pathogenesis.

Customer Reviews (3)

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Reviews
02/20/2022

    Effective in T-cell activation. -

    03/18/2021

      High specificity. -

      08/11/2018

        Suitable for ELISA. -

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