• Official Full Name

    interleukin 18 receptor 1

  • Overview

    The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to
  • Synonyms

    IL18R1; interleukin 18 receptor 1; interleukin-18 receptor 1; CD218 antigen-like family member A; CD218a; CDw218a; CDw218a antigen; IL 1Rrp; IL-18R-1; IL-18R1; IL-1Rrp; IL1 receptor related protein; IL1 receptor-related protein; IL18R_HUMAN; IL18RA; Il18ralpha; IL1R-rp; IL1RRP; Interleukin 18 receptor, alpha chain; interleukin 1 receptor related protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Canine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • C
  • hFc
  • His
  • mFc
  • Fc
  • Fc|His
  • Avi
  • His (Fc)
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL18R1-2254H Recombinant Human IL18R1, Fc-His tagged Human Cell Fc/His
Human Il18r1-2207M Recombinant Mouse Interleukin 18 Receptor 1, His-tagged Human Cell His
Human IL18R1-191H Recombinant Human IL18R1, His-tagged HEK293 His
Human IL18R1-1657H Recombinant Human Interleukin 18 Receptor 1 Mammalian cells N/A
Human IL18R1-165H Recombinant Human IL18R1 protein(Ala19-Arg329), hFc-tagged HEK293 C-hFc Ala19-Arg329
Human IL18R1-1749H Recombinant Human IL18R1 protein, His-tagged E.coli His Tyr375~Glu428 (Accession # Q13478)
Human IL18R1-2253H Recombinant Human IL18R1, His tagged HEK293 His Met 1-Arg 329
Human IL18R1-14163H Recombinant Human IL18R1, His-tagged E.coli His 1-334a.a.
Human IL18R1-2587HCL Recombinant Human IL18R1 cell lysate Human Cell N/A
Human IL18R1-158H Recombinant Human IL18R1 Protein, His-tagged E.coli His
Human IL18R1-2035H Recombinant Human IL18R1 Protein, Fc/His-tagged HEK293 Fc/His Glu20-Arg329
Human IL18R1-2630H Active Recombinant Human IL18R1 protein, hFc&His-tagged HEK293 hFc&His Glu20-Arg329
Human IL18R1-1666H Recombinant Human IL18R1 Protein, His&GST-tagged E.coli N-His&GST Tyr375-Glu428
Human IL18R1-1862H Active Recombinant Human IL18R1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala19-Arg329
Human IL18R1-4437H Recombinant Human IL18R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL18R1-4437H-B Recombinant Human IL18R1 Protein Pre-coupled Magnetic Beads HEK293
Human IL18R1-1854H Active Recombinant Human IL18R1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Ala19-Arg329
Human IL18R1-0920H Recombinant Human IL18R1 Protein (Thr147-Asn255), N-His tagged E.coli N-His Thr147-Asn255
Human IL18R1-314H Recombinant Human IL18R1 Protein, Fc-tagged HEK293 Fc 541
Human IL18R1-5251H Recombinant Human IL18R1 Protein (Met1-Arg329), C-His tagged Mammalian cells C-His Met1-Arg329
Human IL18R1-0262H Active Recombinant Human IL18R1 protein, Fc-tagged HEK293 Fc Ala19-Arg329
Mouse IL18R1-2364M Recombinant Mouse IL18R1 protein(Met1-Gly326), mFc-tagged HEK293 C-mFc Met1-Gly326
Mouse Il18r1-1750M Recombinant Mouse Il18r1 protein, His-tagged E.coli His Thr391~Ala518 (Accession # Q61098)
Mouse Il18r1-3319M Recombinant Mouse Il18r1 protein, His&hFc-tagged HEK293 His&hFc Met1-Gly326
Mouse Il18r1-1751M Recombinant Mouse Il18r1 protein, His-tagged E.coli His Cys182~Val336 (Accession # Q61098)
Mouse Il18r1-839M Recombinant Mouse Il18r1 Protein, His-tagged HEK293 His
Mouse IL18R1-2785MCL Recombinant Mouse IL18R1 cell lysate Human Cell N/A
Mouse CAB11563RM Rabbit Anti-Mouse Interleukin-18 Receptor 1 Monoclonal Antibody Rabbit N/A
Rat IL18R1-163R Recombinant Rat Il18r1, His tagged Human Cell His
Rat Il18r1-7454R Recombinant Rat Il18r1 protein(Met1-Gly326), hFc-tagged HEK293 C-hFc Met1-Gly326
Rat IL18R1-829RCL Recombinant Rat IL18R1 cell lysate Human Cell N/A
Rat Il18r1-1667R Recombinant Rat Il18r1 Protein, His&GST-tagged E.coli N-His&GST Ala18-His321
Canine IL18R1-173C Recombinant Canine IL18R1, Fc tagged Human Cell His
Canine IL18R1-1048C Recombinant Canine IL18R1 Protein, His-tagged HEK293 His
Canine IL18R1-837CCL Recombinant Canine IL18R1 cell lysate Human Cell N/A
Canine IL18R1-1978C Recombinant Canine IL18R1 protein, hFc-tagged HEK293 hFc Met1-Arg327
Cynomolgus Monkey IL18R1-81C Recombinant Cynomolgus IL18R1, Fc tagged Human Cell Fc
Cynomolgus Monkey IL18R1-207C Recombinant Cynomolgus IL18R1, His-tagged Human Cell His Met1-Lys315
Cynomolgus Monkey IL18R1-001CCL Recombinant Cynomolgus IL18R1 cell lysate Human Cell N/A
Chicken IL18R1-3911C Recombinant Chicken IL18R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL18R1 involved in several pathways and played different roles in them. We selected most pathways IL18R1 participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIl23a; Il12b;IFNG1-2;KITLGA;IL2RGB;GH2;IFNAR2;EPOR;Il23a;IL17RA
Inflammatory bowel disease (IBD)TGFB2;HLA-DRB4;IL23R;RORC;IL1A;IFNGR1;IL12RB1;HLA-DOA;HLA-DQA1

IL18R1 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-18 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18R1 itself. We selected most functions IL18R1 had, and list some proteins which have the same functions with IL18R1. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 receptor activityIL1RL2;IL1RL1;IL18R1;IL1RAPL2;IL1R1;IL1R2;IL1RAP;IL1RAPL1A
interleukin-18 receptor activity

IL18R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18R1.


Gene Family


Research Area

Related articles

Ovsyannikova, IG; Haralambieva, IH; et al. Genetic Variation in IL18R1 and IL18 Genes and Inteferon gamma ELISPOT Response to Smallpox Vaccination: An Unexpected Relationship. JOURNAL OF INFECTIOUS DISEASES 208:1422-1430(2013).
Haralambieva, IH; Ovsyannikova, IG; et al. Common SNPs/Haplotypes in IL18R1 and IL18 Genes Are Associated With Variations in Humoral Immunity to Smallpox Vaccination in Caucasians and African Americans. JOURNAL OF INFECTIOUS DISEASES 204:433-441(2011).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How do researchers study the co-receptor interactions involving IL18R1 and IL18RAP, and what methods are employed to decipher their cooperative signaling effects? 09/05/2022

Co-immunoprecipitation, co-receptor binding assays, and functional studies unveil the cooperative roles of IL18R1 and IL18RAP in signaling.

How are imaging techniques, such as fluorescence microscopy and live-cell imaging, applied to visualize the dynamics of IL18R1 localization and clustering upon IL18 stimulation? 04/09/2021

Fluorescence microscopy, confocal imaging, and super-resolution microscopy visualize IL18R1 dynamics and clustering upon IL18 stimulation.

What experimental methods are employed to investigate the post-translational modifications of IL18R1 and their impact on receptor function and downstream signaling? 10/05/2020

Mass spectrometry, phosphorylation assays, and ubiquitination studies investigate IL18R1 post-translational modifications.

How do researchers experimentally explore the role of IL18R1 in disease contexts, and what techniques are used to assess its potential as a therapeutic target? 08/05/2019

Disease model assessments, patient sample analyses, and pharmacological interventions explore IL18R1's involvement in diseases and therapeutic potential.

Could you explain the strategies used to assess the expression levels and tissue distribution of IL18R1 in different cell types and under varying physiological conditions? 04/26/2019

RT-qPCR, flow cytometry, and single-cell RNA sequencing assess IL18R1 expression across different cell types and physiological states.

Can you provide insights into the use of knockout mice, knockdown approaches, and gene editing techniques to elucidate the physiological importance of IL18R1? 03/14/2019

Knockout models, siRNA-mediated knockdown, and CRISPR/Cas9 gene editing reveal the physiological roles of IL18R1 in vivo and in vitro.

What cellular assays and functional studies are commonly utilized to investigate the downstream signaling cascades activated by IL18R1 upon IL18 binding? 09/19/2018

Western blotting, ELISAs, and phosphoprotein analyses decipher IL18R1-mediated signaling cascades and cytokine production.

What experimental approaches are commonly used to dissect the role of IL18R1's extracellular and intracellular domains in mediating IL18-induced immune responses? 06/24/2018

Site-directed mutagenesis, chimera studies, and domain swapping experiments dissect the functional contributions of IL18R1's domains.

Can you elaborate on the techniques used to investigate the structural basis of IL18R1's interaction with IL18 and its implications for downstream signaling? 10/04/2017

X-ray crystallography, cryo-electron microscopy, and molecular dynamics simulations elucidate the structural basis of IL18R1-IL18 recognition and activation.

How do researchers experimentally validate the binding affinity and kinetics of IL18R1 to IL18, considering their central role in initiating IL18-mediated signaling pathways? 09/07/2017

Surface plasmon resonance, bio-layer interferometry, and kinetic binding assays quantify IL18R1-IL18 interactions.

Customer Reviews (3)

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    Low endotoxin levels.


      Good for flow cytometry.


        Potent in Th1 activation.

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