The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to
Synonyms
IL18R1; interleukin 18 receptor 1; interleukin-18 receptor 1; CD218 antigen-like family member A; CD218a; CDw218a; CDw218a antigen; IL 1Rrp; IL-18R-1; IL-18R1; IL-1Rrp; IL1 receptor related protein; IL1 receptor-related protein; IL18R_HUMAN; IL18RA; Il18ralpha; IL1R-rp; IL1RRP; Interleukin 18 receptor, alpha chain; interleukin 1 receptor related protein;
IL18R1 involved in several pathways and played different roles in them. We selected most pathways IL18R1 participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
IL18R1 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-18 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18R1 itself. We selected most functions IL18R1 had, and list some proteins which have the same functions with IL18R1. You can find most of the proteins on our site.
IL18R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18R1.
IL18
Ovsyannikova, IG; Haralambieva, IH; et al. Genetic Variation in IL18R1 and IL18 Genes and Inteferon gamma ELISPOT Response to Smallpox Vaccination: An Unexpected Relationship. JOURNAL OF INFECTIOUS DISEASES 208:1422-1430(2013).
Haralambieva, IH; Ovsyannikova, IG; et al. Common SNPs/Haplotypes in IL18R1 and IL18 Genes Are Associated With Variations in Humoral Immunity to Smallpox Vaccination in Caucasians and African Americans. JOURNAL OF INFECTIOUS DISEASES 204:433-441(2011).
