Recombinant Human Interleukin 18 Receptor 1

• Cat.No.: IL18R1-1657H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: The interleukin-18 receptor 1 (IL-18R1) is a cytokine receptor of the immunoglobulin superfamily. IL18R1 is also known as IL-18Rα, CDw218a (cluster of differentiation w218a), IL-1Rrp, and IL-1R family member. IL-18R1 specifically binds to interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL-18Rα is expressed on Th1 cells, NK cell subset, neutrophils and IL-12-stimulated tonsillar B cells. By itself, IL-18Rα binds IL-18 with low affinity and when complexed with IL-18Rβ chain binds IL-18 with high affinity. The proinflammatory cytokine IL-18 and its receptor complex play an important role in the innate and autoimmune responses.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-18 Rα is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 95-105 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: IL18R1 interleukin 18 receptor 1 [ Homo sapiens ]
• Synonyms: IL18R1; interleukin 18 receptor 1; CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; cytokine receptor; OTTHUMP00000161340; OTTHUMP00000203113; IL1 receptor-related protein; CD218 antigen-like family member A; CD218a antigen; cytokine receptor; Interleukin-18 receptor 1
• Gene ID: 8809
• mRNA Refseq: NM_003855
• Protein Refseq: NP_003846
• MIM: 604494
• UniProt ID: Q13478
• Chromosome Location: 2q12
• Pathway: Cytokine-cytokine receptor interaction
• Function: interleukin-1 receptor activity; transmembrane receptor activity