INPP5D

  • Official Full Name

    inositol polyphosphate-5-phosphatase, 145kDa

  • Overview

    SHIP-1 p145 (SH2-containing-inositol phosphatase), an effector molecule, associates with activated Fms oncogenes. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 -tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.

  • Synonyms

    INPP5D;inositol polyphosphate-5-phosphatase, 145kDa;inositol polyphosphate 5 phosphatase, 145kD;phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1;hp51CN;SHIP;SHIP-1;p150Ship;SH2 domain-containing inositol phosphatase 1;SH2 containing inositol phosphatase, isoform b;SH2 domain-containing inositol 5-phosphatase 1;SH2 domain-containing inositol-5-phosphatase 1;inositol polyphosphate-5-phosphatase of 145 kDa;signaling inositol polyphosphate 5 phosphatase SIP-145;phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1;SHIP1;SIP-145;MGC104855;MGC142140;MGC142142

Recombinant Proteins

  • Rat
  • Mouse
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag

    Involved Pathway

    INPP5D involved in several pathways and played different roles in them. We selected most pathways INPP5D participated on our site, such as Inositol phosphate metabolism,Phosphatidylinositol signaling system,B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phosphatidylinositol signaling system CALM1,MTMR3,CALM4,PI4KAA,INPP4A,MTMR1,PIK3CG,INPP5K,PIK3C3,PLCB1
    Inositol phosphate metabolism NUDT4A,PIK3C2A,PIP4K2B,ITPK1,PTEN,PIP5K1B,NUDT4,NUDT3A,PIP4K2A,PIP5K1BB
    Fc epsilon RI signaling pathway VAV2,RAC1,PIK3CG,FYN,GRB2,SYK,PLCG1,LAT,HRAS,PIK3R5
    Fc gamma R-mediated phagocytosis CFL1,PIK3R3,LYN,SPHK1,WASF2,CDC42,PPAP2C,FCGR3A,PPAP2A,PRKCE
    B Cell Receptor Signaling Pathway CDK6,MAP2K2,ARPC2,MAPK4,CD79B,VAV2,NRAS,DOK1,cgr2b,BCL2L11

    Protein Function

    INPP5D has several biochemical functions, for example, PTB domain binding,SH3 domain binding,inositol-polyphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5D itself. We selected most functions INPP5D had, and list some proteins which have the same functions with INPP5D. You can find most of the proteins on our site.

    Function Related Protein
    phosphatidylinositol trisphosphate phosphatase activity INPP5K,INPP4B
    PTB domain binding APP,NUP62,INSR
    protein binding TNNI3,INPP5B,SLC30A1,MCEE,DCDC2,PPM1F,LRP12,NR2F1,CDKL3,CXCR5
    inositol-polyphosphate 5-phosphatase activity INPPL1,INPP5E,INPP5K,INPP5A,INPP5J
    SH3 domain binding ITM2B,AFAP1L2,DENND1A,INPPL1,ELMO3,CASP9,LYN,SHANK1,EVL,MYPN

    Interacting Protein

    INPP5D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5D here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5D.

    KHDRBS3;FCGR2B;KRTAP10-7;KRTAP10-9;KRT31;KRT40

    Resources

    Research Area

    Phosphatases and Regulators
    Phosphatases Localized to Focal Adhesions
    T Follicular Helper (Tfh) Cells

    References

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