| Description : |
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
133 kDa |
| AA Sequence : |
MVPCWNHGNITRSKAEELLSRTGKD GSFLVRASESISRAYALCVLYRNCV YTYRILPNEDDKFTVQASEGVSMRF FTKLDQLIEFYKKENMGLVTHLQYP VPLEEEDTGDDPEEDTESVVSPPEL PPRNIPLTASSCEAKEVPFSNENPR ATETSRPSLSETLFQRLQSMDTSGL PEEHLKAIQDYLSTQLAQDSEFVKT GSSSLPHLKKLTTLLCKELYGEVIR TLPSLESLQRLFDQQLSPGLRPRPQ VPGEANPINMVSKLSQLTSLLSSIE DKVKALLHEGPESPHRPSLIPPVTF EVKAESLGIPQKMQLKVDVESGKLI IKKSKDGSEDKFYSHKKILQLIKSQ KFLNKLVILVETEKEKILRKEYVFA DSKKREGFCQLLQQMKNKHSEQPEP DMITIFIGTWNMGNAPPPKKITSWF LSKGQGKTRDDSADYIPHDIYVIGT QEDPLSEKEWLEILKHSLQEITSVT FKTVAIHTLWNIRIVVLAKPEHENR ISHICTDNVKTGIANTLGNKGAVGV SFMFNGTSLGFVNSHLTSGSEKKLR RNQNYMNILRFLALGDKKLSPFNIT HRFTHLFWFGDLNYRVDLPTWEAET IIQKIKQQQYADLLSHDQLLTERRE QKVFLHFEEEEITFAPTYRFERLTR DKYAYTKQKATGMKYNLPSWCDRVL WKSYPLVHVVCQSYGSTSDIMTSDH SPVFATFEAGVTSQFVSKNGPGTVD SQGQIEFLRCYATLKTKSQTKFYLE FHSSCLESFVKSQEGENEEGSEGEL VVKFGETLPKLKPIISDPEYLLDQH ILISIKSSDSDESYGEGCIALRLEA TETQLPIYTPLTHHGELTGHFQGEI KLQTSQGKTREKLYDFVKTERDESS GPKTLKSLTSHDPMKQWEVTSRAPP CSGSSITEIINPNYMGVGPFGPPMP LHVKQTLSPDQQPTAWSYDQPPKDS PLGPCRGESPPTPPGQPPISPKKFL PSTANRGLPPRTQESRPSDLGKNAG DTLPQEDLPLTKPEMFENPLYGSLS SFPKPAPRKDQESPKMPRKEPPPCP EPGILSPSIVLTKAQEADRGEGPGK QVPAPRLRSFTCSSSAEGRAAGGDK SQGKPKTPVSSQAPVPAKRPIKPSR SEINQQTPPTPTPRPPLPVKSPAVL HLQHSKGRDYRDNTELPHHGKHRPE EGPPGPLGRTAMQTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
