IRAK3

  • Official Full Name

    interleukin-1 receptor-associated kinase 3

  • Overview

    This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
  • Synonyms

    IRAK3; interleukin-1 receptor-associated kinase 3; ASRT5; IRAKM; IL-1 receptor-associated kinase M;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRAK3-7003H Recombinant Human IRAK3, GST-tagged Sf9 Insect Cell GST Full length
Human IRAK3-7076H Recombinant Human IRAK3 protein, His-tagged E.coli His Gln201~Cys410 (Accession # Q9Y616)
Human IRAK3-5170HCL Recombinant Human IRAK3 293 Cell Lysate HEK293 N/A
Human IRAK3-5731HF Recombinant Full Length Human IRAK3 Protein, GST-tagged In Vitro Cell Free System GST 596 amino acids
Human IRAK3-1192H Recombinant Human IRAK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IRAK3-1192H-B Recombinant Human IRAK3 Protein Pre-coupled Magnetic Beads HEK293
Human IRAK3-5051H Recombinant Human IRAK3 Protein, GST-tagged Wheat Germ GST
Human IRAK3-1249H Recombinant Human IRAK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IRAK3-1792HFL Recombinant Full Length Human IRAK3 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Irak3-3569M Recombinant Mouse Irak3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Irak3-2234M Recombinant Mouse Irak3 protein, His&Myc-tagged Insect Cell His&Myc 1-609aa
Mouse Irak3-3113M Recombinant Mouse Irak3 protein, His&Myc-tagged E.coli His&Myc 1-609aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IRAK3 involved in several pathways and played different roles in them. We selected most pathways IRAK3 participated on our site, such as Activated TLR4 signalling, Apoptosis, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated TLR4 signallingTIRAP;DUSP6;IRAK3;CREB1B;S100B;SIGIRR;TLR6;ALCAMB;NOD1
ApoptosisBIRC7;DIABLOB;CDK5RAP2;AKT2;PIK3CB;CASP2;NFKB1;IRF4A;DBNLA
Cytokine Signaling in Immune systemXAF1;TRIM48;TRIM46;PEBP1;TRIM14;KBTBD7;CSHL1;MARK3;NOD1
IL1-mediated signaling eventsTMEM189-UBE2V1;IRAK3;TMED7-TICAM2;IL1RN
Immune SystemRNF144B;WASF2;TRIM46;DEFB129;RCA2.1;RAP1GAP2;SIGLEC12;EGR1;CLEC5A
Innate Immune SystemS100B;GZMM;NLRC5;CFHL1;LGALS3;DDOST;CYLD;BTR18;ART1
Interleukin-1 signalingNOD1;IL1RN;PELI3;IRAK3;TNIP2;PELI2;PELI1
MyD88:Mal cascade initiated on plasma membraneIRAK3;SIGIRR

IRAK3 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK3 itself. We selected most functions IRAK3 had, and list some proteins which have the same functions with IRAK3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPDK4;NME7;Acsm2a;PRKCBB;PKZ;EPHA10;LATS1;ATP6V1A;ABCA7
magnesium ion bindingIDH2;ENOSF1;HPRT1;ENO1B;PGM5;PSPH;MAPK12;HPGDS;MTHFD2
protein heterodimerization activityMAFA;TERF1;HEXA;H3F3B;HIST1H2BI;LIMK2;KCNB2;CXorf15;MYOG
protein homodimerization activityCHMP3;DMRT3A;VPS25;NTRK2;UNC13A;MAFA;GZMA;TFRC;XPNPEP1
protein serine/threonine kinase activitySTK32B;NEK2;PSKH2;TGFBR1B;PRKCBA;TTK;PIM3;LRRK1;AAK1

IRAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK3.

IRAK2; IRAK1; CD14; HOXB7; HSP90AB1; MYD88; TRAF6; NSA2; ADH1B; FOLR1; COPB1; NONO; NTRK3

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