IRAK3
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Official Full Name
interleukin-1 receptor-associated kinase 3
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Background
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] -
Synonyms
IRAK3; interleukin-1 receptor-associated kinase 3; ASRT5; IRAKM; IL-1 receptor-associated kinase M;
- Involved Pathway
- Protein Function
- Interacting Protein
IRAK3 involved in several pathways and played different roles in them. We selected most pathways IRAK3 participated on our site, such as Activated TLR4 signalling, Apoptosis, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | CHST13;DHX9;MAPK14;PELI1;MAPKAPK2B;UBE2V1;JUN;ALCAMB;CREB1 |
| Apoptosis | PIK3CD;IRAK2;IRF4A;DSG3;IL1B;IL3;BOK;IL1A;LMNB1 |
| Cytokine Signaling in Immune system | TRIM68;TRIM31;TRIM45;HLA-DQB2;FGFR1B;IRF2;EIF4G2;EIF4A2;ARIH1 |
| IL1-mediated signaling events | TMEM189-UBE2V1;IRAK3;TMED7-TICAM2;IL1RN |
| Immune System | CD207;RNF14;PANX1;UBE2U;KLHL20;PELI3;DYNC1H1;TXNIP;SEC23A |
| Innate Immune System | CYLD;DEFB104A;BFB;DUSP3;DEFA6;TXNIP;KIR3DS1;CASP2;NLRC5 |
| Interleukin-1 signaling | NOD1;IL1RN;PELI1;TNIP2;IRAK3;PELI3;PELI2 |
| MyD88:Mal cascade initiated on plasma membrane | IRAK3;SIGIRR |
IRAK3 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK3 itself. We selected most functions IRAK3 had, and list some proteins which have the same functions with IRAK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DCLK1;UBE2S;RIPK3;TP53;PRKCHA;FYNA;CKMT2B;PNCK;MAP4K2 |
| magnesium ion binding | PPM1BB;PRPSAP1;ENO1B;RPS6KA4;ATP9A;NT5C3B;PPM1NB;DOM3Z;PDXK |
| protein heterodimerization activity | BMP2B;JAM2A;LIFR;TIRAP;HIST1H2BN;TAF4B;GUCY1A3;NEUROD1;PANX1 |
| protein homodimerization activity | GLIPR2;DGCR8;DMBX1;PVRL1;DMRT2B;LRRC41;CHMP4C;NLRC4;AMBP |
| protein serine/threonine kinase activity | CAMK1DB;PDK3;GRK7A;EIF2AK3;TBK1;DMPK;BMPR1AB;CAMK2G1;CDC42BPG |
IRAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK3.
IRAK2; IRAK1; CD14; HOXB7; HSP90AB1; MYD88; TRAF6; NSA2; ADH1B; FOLR1; COPB1; NONO; NTRK3
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