IRAK3

  • Official Full Name

    interleukin-1 receptor-associated kinase 3
  • Overview

    This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
  • Synonyms

    IRAK3;interleukin-1 receptor-associated kinase 3;ASRT5;IRAKM;IL-1 receptor-associated kinase M

Recombinant Proteins

  • Human
  • Mouse
  • Sf9 Cells
  • E.coli
  • HEK293
  • Mammalian Cells
  • Insect Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
IRAK3-7003H Recombinant Human IRAK3, GST-tagged Sf9 Cells Human GST Full length
IRAK3-7076H Recombinant Human IRAK3 protein, His-tagged E.coli Human His Gln201~Cys410
IRAK3-5170HCL Recombinant Human IRAK3 293 Cell Lysate HEK293 Human Non
IRAK3-1192H Recombinant Human IRAK3 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IRAK3-1192H-B Recombinant Human IRAK3 Protein Pre-coupled Magnetic Beads HEK293 Human
IRAK3-1249H Recombinant Human IRAK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IRAK3-1792HFL Recombinant Full Length Human IRAK3 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
Irak3-2234M Recombinant Mouse Irak3 protein, His&Myc-tagged Insect Cells Mouse His&Myc 1-609aa
Irak3-3113M Recombinant Mouse Irak3 protein, His&Myc-tagged E.coli Mouse His&Myc 1-609aa
Irak3-3569M Recombinant Mouse Irak3 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
IRAK3-5051H Recombinant Human IRAK3 Protein, GST-tagged Wheat Germ Human GST
IRAK3-5731HF Recombinant Full Length Human IRAK3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 596 amino acids

    Involved Pathway

    IRAK3 involved in several pathways and played different roles in them. We selected most pathways IRAK3 participated on our site, such as Activated TLR4 signalling,Apoptosis,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MyD88:Mal cascade initiated on plasma membrane SIGIRR
    Innate Immune System NLRP4,MGC174155,CD180,CLEC4D,CLEC4A,TRIM56,NLRC5,PELI3,CR1,DEFA1
    Cytokine Signaling in Immune system JAK3,EGR1,IRF4,GBP4,OASL,IFIT14,DAB2IPB,DUSP4,FGF8B,FGF20A
    Activated TLR4 signalling ALCAMB,CREB1B,TLR6,APPA,DUSP3,S100A12,MAP3K8,TAB1,ATF2,MAPK14
    Immune System CNPY3,HERC5,ERAP1,WWP1,ERAP2,CTSK,IFI16,CD300LF,KLRB1F,EIF4E3
    Interleukin-1 signaling PELI1,PELI2,PELI3,NOD1,IL1RN,TNIP2
    Apoptosis FADD,FASLG,BCL2A,TNF,IRF1B,CFLAR,RNF8,CASP7,DIABLOA,Casp3
    IL1-mediated signaling events TMEM189-UBE2V1,TMED7-TICAM2,IL1RN

    Protein Function

    IRAK3 has several biochemical functions, for example, ATP binding,magnesium ion binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK3 itself. We selected most functions IRAK3 had, and list some proteins which have the same functions with IRAK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding KSR1,SMC6,P2RY1,NME2A,KCNJ8,TTN,PRKACA,NLRP4B,CHST13,ACTA1A
    magnesium ion binding PAPOLA,ADSSL1,CIB2,RPS6KAL,DXO,PGM3,PRPS1A,ENO1,NUDT3,NUDT18
    protein homodimerization activity Flt3l,MYH9,PEX7,HM13,GRM6,SLC9A7,TMEM192,PPP2R4,TRIM5,GRIK2
    protein heterodimerization activity BNIP3,PKNOX1,H2-AA,SOX9,RRAGD,TGFB1,AGTR1A,USF1,SAE1,DRD1A
    protein serine/threonine kinase activity GSK3A,ULK3,ADCK2,CSNK1G2A,PRKACBA,PAK4,NUAK2,PAK2A,STK40,HIPK4

    Interacting Protein

    IRAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK3.

    IRAK2;IRAK1;CD14;HOXB7;HSP90AB1;MYD88;TRAF6;NSA2;ADH1B;FOLR1;COPB1;NONO;NTRK3

    Resources

    References

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