IRAK3

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IRAK3

Official Full Name interleukin-1 receptor-associated kinase 3
Background This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Synonyms IRAK3; interleukin-1 receptor-associated kinase 3; ASRT5; IRAKM; IL-1 receptor-associated kinase M;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His&Myc
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Irak3-2234M Recombinant Mouse Irak3 protein, His&Myc-tagged Insect Cell His&Myc
    Mouse Irak3-3113M Recombinant Mouse Irak3 protein, His&Myc-tagged E.coli His&Myc
    Human IRAK3-1249H Recombinant Human IRAK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IRAK3-5051H Recombinant Human IRAK3 Protein, GST-tagged Wheat Germ GST
    Human IRAK3-5170HCL Recombinant Human IRAK3 293 Cell Lysate HEK293 N/A
    Human IRAK3-7003H Recombinant Human IRAK3, GST-tagged Sf9 Insect Cell GST
    Human IRAK3-7076H Recombinant Human IRAK3 protein, His-tagged E.coli His
    Mouse Irak3-3569M Recombinant Mouse Irak3 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    IRAK3 involved in several pathways and played different roles in them. We selected most pathways IRAK3 participated on our site, such as Activated TLR4 signalling, Apoptosis, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling SAA1; ALCAMB; JUN; DHX9; TICAM1; TNIP2; DUSP7; DUSP6; CHUK; PELI3
    Apoptosis VIML; PRKAR1B; PRKAR2A; TRAF2; CFLARA; DBNL; CASP6L1; XIAP; HDR; GAS2
    Cytokine Signaling in Immune system TRIM14; DUSP4; TRIM17; MARK3; CSH1; CASPBL; PELI3; PELI1; KBTBD7; ADAR
    IL1-mediated signaling events IRAK3; IL1RN; TMED7-TICAM2; TMEM189-UBE2V1
    Immune System CD96; CFHL3; KIR3DS1; TRIM6; NA; RNF216; FBXO44; POLR3G; TXNIPB; KIF3B
    Innate Immune System MYO1C; CTS7; DEFB103A; FCN3; DEFB125; ALCAMB; NLRC5; PLD4; MYO9B; CRP
    Interleukin-1 signaling PELI2; NOD1; PELI3; IL1RN; PELI1; IRAK3; TNIP2
    MyD88:Mal cascade initiated on plasma membrane IRAK3; SIGIRR

    IRAK3 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK3 itself. We selected most functions IRAK3 had, and list some proteins which have the same functions with IRAK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TAE1; GSK3AB; RTCD1; TPX2; AASDH; CHD2; CCC2; KIFC1; DDX47; TARS2
    magnesium ion binding NUAK2; SRPK1; FOXK2; STK36; ADPRH; TREX2; RPS6KA1; ABL1; PTENA; NIM1
    protein heterodimerization activity EGFR; HIST3H2A; SAE1; ZHX2; PPP3CA; TYR; TCF12; SOX6; CD3E; TAF9B
    protein homodimerization activity PLOD1; GYS2; FAM109B; TPD52L2; ADSSL1; DROSHA; SRGAP2A; KLRB1B; CALCOCO2; SP1
    protein serine/threonine kinase activity MAPK8; GRK1A; NEK3; GRK7A; SGK2A; NIM1K; NEK11; HIPK4; AKT2L; CDK1

    IRAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK3.

    IRAK2; IRAK1; CD14; HOXB7; HSP90AB1; MYD88; TRAF6; NSA2; ADH1B; FOLR1; COPB1; NONO; NTRK3

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