• Official Full Name

    integrin, alpha X (complement component 3 receptor 4 subunit)

  • Overview

    This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit); CD11C; SLEB6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag|His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGAX-1553H Recombinant Human ITGAX protein, His-tagged E.coli His
Human ITGAX-266H Recombinant Human ITGAX Mammalian Cell His
Human ITGAX-4119H Recombinant Human ITGAX, flag & His tagged Human Cell Flag/His
Human ITGAX & ITGB2-1875HCL Recombinant Human ITGAX & ITGB2 cell lysate Human Cell N/A
Human ITGAX-4324H Recombinant Human ITGAX Protein (Met1-Pro1107), C-His tagged Mammalian cells C-His
Human ITGAX-4987H Recombinant Human ITGAX Protein, GST-tagged Wheat Germ GST
Human ITGAX-183H Recombinant Human ITGAX protein, His-tagged E. coli His
Human ITGAX-3177H-B Recombinant Human ITGAX Protein Pre-coupled Magnetic Beads HEK293
Human ITGAX-1223H Recombinant Human ITGAX Protein (Phe20-Pro1107), N-His tagged E.coli N-His
Human ITGAX-1066H Recombinant Human ITGAX Protein, His-tagged HEK293F N-His
Human ITGAX-3177H Recombinant Human ITGAX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Itgax-1554M Recombinant Mouse Itgax protein, His & GST-tagged E.coli His/GST
Mouse ITGAX-2812M Recombinant Mouse ITGAX Protein (20-1116 aa), His-MBP-tagged Insect Cell His/Myc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGAX Related Articles
  • ITGAX Related Research Area

ITGAX involved in several pathways and played different roles in them. We selected most pathways ITGAX participated on our site, such as Regulation of actin cytoskeleton, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of actin cytoskeletonMYL9A;PDGFD;PIP5K1AB;ACTG1;FGF6B;Pdgfa&Pdgfb;DIAPH1;GNA12A;CYFIP1

ITGAX has several biochemical functions, for example, metal ion binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAX itself. We selected most functions ITGAX had, and list some proteins which have the same functions with ITGAX. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingDNMT3B;CHN2;BCL11B;ACVR1C;ZHX3;IKZF1;THAP4;CYP2Y3;ZFYVE26
protein bindingPRPF4B;TTC17;CTNNBL1;C1orf65;PTGES2;KLRC2;IRF7;VRK2;VPS53

ITGAX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAX here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAX.

ITGB2; pepT

Immig, K; Gericke, M; et al. CD11c-Positive Cells from Brain, Spleen, Lung, and Liver Exhibit Site-Specific Immune Phenotypes and Plastically Adapt to New Environments. GLIA 63:611-625(2015).
Williams, KA; Lee, M; et al. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLOS GENETICS 10:-(2014).
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