|Official Full Name||karyopherin alpha 5 (importin alpha 6)|
|Background||The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.|
|Synonyms||KPNA5; karyopherin alpha 5 (importin alpha 6); importin subunit alpha-6; IPOA6; SRP6; IMA5_HUMAN; Importin alpha 6; Importin subunit alpha 6; IPOA 6; Karyopherin alpha 5; Karyopherin alpha 5 importin alpha 6; Karyopherin subunit alpha 5; Karyopherin subunit alpha-5; KPNA 5; SRP 6; OTTHUMP00000017076|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
kpna5 involved in several pathways and played different roles in them. We selected most pathways kpna5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with kpna5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Antiviral mechanism by IFN-stimulated genes||UBE2L6; ARIH1; EIF4G2A; EIF4G2; IFIT10; EIF4G1; IFIT14; NUP35; EIF4A2; KPNA5|
|Cytokine Signaling in Immune system||FGF10B; IRF6; DUSP10; DAB2IPB; CSF2RA; GBP5; JAK3; EIF4G2A; IRF2; HLA-DQB2|
|Disease||TLR10; AP2B1; RPL35; OPN1SW; AP2M1; AP2A1; CCDC59; AP1B1; CDK9; KREMEN2|
|Host Interactions with Influenza Factors||KPNA5; KPNA3; KPNA4; CPSF4|
|ISG15 antiviral mechanism||IFIT12; IFIT8; ARIH1; HERC5; ARIH1L; USP18; EIF4E3; KPNA5; EIF4G2; EIF4G2A|
|Immune System||AMICA1; SIGLEC12; DEFB119; PANX1B; DCTN6; WIPF3; TNFRSF13C; AGER; FCN1; SEC23A|
|Infectious disease||PPIAL4A; NMT2; DOCK2; AP1M2; VPS37A; CHMP4C; TAF1L; NMT1; SYT2; APOBEC3G|
|Influenza Infection||CPSF4; IPO5; KPNA4; KPNA5; KPNA3|
kpna5 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kpna5 itself. We selected most functions kpna5 had, and list some proteins which have the same functions with kpna5. You can find most of the proteins on our site.
|nuclear localization sequence binding||KPNA2; RANBP6; KPNA3; TNPO3; IPO13; BRAP; NUP214; KPNA1; KPNB1; KPNA5|
|protein binding||KRT6B; VAT1L; COX17; USP1; SEPT9; VSIG4; RNF43; COX4I1; TRDN; DAK|
|protein transporter activity||AP1S1; AP2B1; SNUPN; ITGB1BP1; AP2S1; SOSTDC1B; CHMP7; COX18; SEC62; KPNA6|
kpna5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kpna5 here. Most of them are supplied by our site. Hope this information will be useful for your research of kpna5.
CDKN1B; SPOPL; ANP32B; NUP50; csp_playo; SKP2; ANP32A; SF1; q5nem9_fratt