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Official Full Name karyopherin alpha 5 (importin alpha 6)
Background The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
Synonyms KPNA5; karyopherin alpha 5 (importin alpha 6); importin subunit alpha-6; IPOA6; SRP6; IMA5_HUMAN; Importin alpha 6; Importin subunit alpha 6; IPOA 6; Karyopherin alpha 5; Karyopherin alpha 5 importin alpha 6; Karyopherin subunit alpha 5; Karyopherin subunit alpha-5; KPNA 5; SRP 6; OTTHUMP00000017076
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KPNA5-29811TH Recombinant Human KPNA5 Wheat Germ N/A
    Human KPNA5-4888HCL Recombinant Human KPNA5 293 Cell Lysate HEK293 N/A
    Human KPNA5-4893H Recombinant Human KPNA5 Protein, GST-tagged Wheat Germ GST
    Human KPNA5-86H Recombinant Human KPNA5 protein, T7/His-tagged E.coli T7/His
    Rat KPNA5-3303R Recombinant Rat KPNA5 Protein Mammalian Cell His
    Zebrafish KPNA5-2661Z Recombinant Zebrafish KPNA5 Mammalian Cell His

    kpna5 involved in several pathways and played different roles in them. We selected most pathways kpna5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with kpna5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antiviral mechanism by IFN-stimulated genes UBE2L6; ARIH1; EIF4G2A; EIF4G2; IFIT10; EIF4G1; IFIT14; NUP35; EIF4A2; KPNA5
    Cytokine Signaling in Immune system FGF10B; IRF6; DUSP10; DAB2IPB; CSF2RA; GBP5; JAK3; EIF4G2A; IRF2; HLA-DQB2
    Disease TLR10; AP2B1; RPL35; OPN1SW; AP2M1; AP2A1; CCDC59; AP1B1; CDK9; KREMEN2
    Host Interactions with Influenza Factors KPNA5; KPNA3; KPNA4; CPSF4
    ISG15 antiviral mechanism IFIT12; IFIT8; ARIH1; HERC5; ARIH1L; USP18; EIF4E3; KPNA5; EIF4G2; EIF4G2A
    Immune System AMICA1; SIGLEC12; DEFB119; PANX1B; DCTN6; WIPF3; TNFRSF13C; AGER; FCN1; SEC23A
    Infectious disease PPIAL4A; NMT2; DOCK2; AP1M2; VPS37A; CHMP4C; TAF1L; NMT1; SYT2; APOBEC3G
    Influenza Infection CPSF4; IPO5; KPNA4; KPNA5; KPNA3

    kpna5 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kpna5 itself. We selected most functions kpna5 had, and list some proteins which have the same functions with kpna5. You can find most of the proteins on our site.

    Function Related Protein
    nuclear localization sequence binding KPNA2; RANBP6; KPNA3; TNPO3; IPO13; BRAP; NUP214; KPNA1; KPNB1; KPNA5
    protein binding KRT6B; VAT1L; COX17; USP1; SEPT9; VSIG4; RNF43; COX4I1; TRDN; DAK
    protein transporter activity AP1S1; AP2B1; SNUPN; ITGB1BP1; AP2S1; SOSTDC1B; CHMP7; COX18; SEC62; KPNA6

    kpna5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kpna5 here. Most of them are supplied by our site. Hope this information will be useful for your research of kpna5.

    CDKN1B; SPOPL; ANP32B; NUP50; csp_playo; SKP2; ANP32A; SF1; q5nem9_fratt

    Chaudhary, SC; Cho, MG; et al. A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met. EXPERIMENTAL AND MOLECULAR MEDICINE 46:-(2014).
    Byrum, CA; Smith, J; et al. Restricted expression of karyopherin alpha mRNA in the sea urchin suggests a role in neurogenesis. GENE EXPRESSION PATTERNS 16:51-60(2014).

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