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KRT81

Official Full Name

Keratin 81
Overview

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
Synonyms

KRT81; keratin 81; HB1; hHb1; Basic Hair Keratin K81; Hb-1; KRTHB1; keratin, type II cuticular Hb1; K81; ghHb1; ghHKb1; MLN 137; keratin-81; hair keratin K2.9; type-II keratin Kb21; keratin, hair, basic, 1; hard keratin, type II, 1; type II hair keratin Hb1; metastatic lymph node 137 gene protein; OTTHUMP00000236200.;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
In Vitro Cell Free System
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KRT81-28044TH	Recombinant Human KRT81	Wheat Germ	Non	202 amino acids	Inquiry
Human	KRT81-958HCL	Recombinant Human KRT81 cell lysate		Non		Inquiry
Human	KRT81-4796H	Recombinant Human KRT81 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	KRT81-270HF	Recombinant Full Length Human KRT81 Protein	In Vitro Cell Free System		202 amino acids	Inquiry
Human	KRT81-1508H	Recombinant Human KRT81 protein, His-tagged	E.coli	His	Gln142~Thr257	Inquiry
Human	KRT81-5836HF	Recombinant Full Length Human KRT81 Protein, GST-tagged	In Vitro Cell Free System	GST	202 amino acids	Inquiry
Human	KRT81-4397H	Recombinant Human KRT81 Protein (Ser266-Gly420), N-His tagged	E.coli	His	Ser266-Gly420	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

KRT81 involved in several pathways and played different roles in them. We selected most pathways KRT81 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT81 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

KRT81 has several biochemical functions, for example, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT81 itself. We selected most functions KRT81 had, and list some proteins which have the same functions with KRT81. You can find most of the proteins on our site.

Function	Related Protein
protein binding	TOR1AIP2;FBXO44;NME1;DERL3;SPATA2;ATPAF1;RADIL;CMTM5;LPAR2
structural molecule activity	CLDNA;CLDN7B;LMNL3;SNTA1;TUBG2;LMNB1;LCE1B;IFFO2;CLDNC

KRT81 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT81 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT81.

KRT38; Hoxa1; OTX1; KRT31; KRT40

Research Area

Kawase, Y; Ogasawara, T; et al. Factors affecting the formation of membranous substances in the palates of elderly persons requiring nursing care. GERODONTOLOGY 31:184-193(2014).

Huang, TY; Chen, SZ; et al. Expression of Hsp90 alpha and cyclin B1 were related to prognosis of esophageal squamous cell carcinoma and keratin pearl formation. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:1544-+(2014).