Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

LAMA5

  • Official Full Name

    laminin, alpha 5

  • Overview

    Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
  • Synonyms

    LAMA5; laminin, alpha 5; laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; KIAA1907;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • Fc
  • His|SUMO
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LAMA5-968HCL Recombinant Human LAMA5 cell lysate N/A
Human LAMA5-2461H Recombinant Human LAMA5 protein(2381-2460 aa), C-His-tagged E. coli C-His 2381-2460 aa
Human LAMA5-1787H Recombinant Human LAMA5 Protein (3401-3692 aa), His-SUMO-tagged E.coli His/SUMO 3401-3692 aa
Human LAMA5-2384H Recombinant Human LAMA5 Protein, His-tagged E.coli N-His Pro2736-Cys2929
Human LAMA5-001H Recombinant Human Laminin 511, Biotin-labeled Tag Free
Human LAMA5-0356H Active Recombinant Human LAMA5 protein, Fc-tagged HEK293 Fc Glu2655-Ala3327(Lamininalpha5E8)&Asp1714-Leu1786(Lamininbeta1E8)&Asp1528-Pro1609(Laminingamma1E8)
Human LAMA5-0375H Active Recombinant Human LAMA5 protein, Fc-tagged HEK293 Fc Glu2655–Ala3327(Lamininalpha5E8)&Leu1573-Gln1798(Lamininbeta2E8)&Asp1528–Pro1609(Laminingamma1E8)
Mouse Lama5-217M Recombinant Mouse Lama5 Protein, His-tagged E.coli His Glu3517~His3718
Zebrafish LAMA5-3613Z Recombinant Zebrafish LAMA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LAMA5 Related Articles

LAMA5 involved in several pathways and played different roles in them. We selected most pathways LAMA5 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayPKN3;FGF6;LPAR4;FGF10;ITGA3;PIK3CA;PRKAA2;PPP2CA;PDGFD
Focal adhesionPDGFA;ROCK2;RAF1B;COL6A5;PDGFD;MAPK1;FLNA;COL2A1A;SEPP1
ECM-receptor interactionITGA7;COL5A2A;CD44;LAMB3;COL1A2;SV2C;COL4A4;IBSP;ITGB1A
ToxoplasmosisHSPA8;HLA-DRB5;MAPK12;Toxoplasma Gondii Major Surface Antigen P30;H2-AB1;PIK3R1;MAPK8;GNAO1;BIRC3
AmoebiasisHSPB1;CTSG;GNAS;C8A;SERPINB1B;TLR4;GM-CSF;PIK3CA;SERPINB1
Pathways in cancerBID;PPARG;PDGFA;RALBP1;GNB1;PLCG2;FZD2;NTRK1;SUFU
Small cell lung cancerBIRC2;RXRA;ITGA3;RELA;PIK3CA;NOS2;XIAP;LAMA1;PIK3R1

LAMA5 has several biochemical functions, for example, integrin binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA5 itself. We selected most functions LAMA5 had, and list some proteins which have the same functions with LAMA5. You can find most of the proteins on our site.

Function Related Protein
integrin bindingCOL4A3;FBLN1;VTN;EGFL6;GPNMB;DMP1;THY1;LAMA5;NIPAL1
structural molecule activityLCE3C;LMNB2;KRT7;CLDN15LB;DESMB;CAV1;CLDN15;CLDN15B;KRT27

LAMA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA5.

DAG1; LAMC1; TFAP2A; CRKL; SMAD2; tktA; ATF7IP; yfiS; MUC7; dnaA; TFAP2C; BTBD10; q9wmx2-pro_0000037548; Mast3; Cenpe; ssrna_ug; RNASEH2A; cona_canen

Hamill, KJ; Langbein, L; et al. Identification of a Novel Family of Laminin N-terminal Alternate Splice Isoforms STRUCTURAL AND FUNCTIONAL CHARACTERIZATION. JOURNAL OF BIOLOGICAL CHEMISTRY 284:35588-35596(2009).
Rebustini, IT; Patel, VN; et al. Laminin alpha 5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta 1 integrin signaling. DEVELOPMENTAL BIOLOGY 308:15-29(2007).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All LAMA5 Products

Required fields are marked with *

My Review for All LAMA5 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends