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LIF

  • Official Full Name

    leukemia inhibitory factor

  • Overview

    LIF (Leukocyte inhibitory factor) is produced by various fibroblast cell lines, antigen-stimulated alloreactive T-lymphocytes, mitogen-activated spleen cells, and Krebs and Ehrlich ascites cells. It is also produced by monocytes after cell activation. This factor inhibits the random and directed migration of polymorphonuclear (PMN) leukocytes. LIF also induces specific granule secretion by PMNs and potentiates many responses mediated by the chemotactic compound fMLP (formyl-methionyl-leucyl-phenylalanine). It activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes.
  • Synonyms

    LIF; leukemia inhibitory factor; CDF; cholinergic differentiation factor; DIA; differentiation inhibitory activity; differentiation inducing factor; hepatocyte stimulating factor III; HILDA; human interleukin in DA cells; D factor; melanoma-derived LPL inhibitor; differentiation-inducing factor; hepatocyte-stimulating factor III; differentiation-stimulating factor; MLPLI;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rat
  • Barley Grain
  • CHO-K1
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Hordeum Vulgare
  • Human Cell
  • Insect Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIF-8868H Active Recombinant Human LIF, His-tagged Hordeum Vulgare N/A
Human LIF-514H Active Recombinant Human LIF E.coli N/A
Human LIF-378H Active Recombinant Human leukemia Inhibitory Factor HEK293 N/A
Human LIF-134H Active Recombinant Human LIF protein, His-tagged Insect Cell His
Human LIF-635H Active Recombinant Human LIF, Fc-tagged, Biotinylated Human Cell Fc
Human LIF-634H Active Recombinant Human LIF, His-tagged, Biotinylated Human Cell His
Human LIF-167H Active Recombinant Human LIF Protein, Biotinylated E.coli N/A Pro24-Phe202
Human LIF-01HG Active GMP Recombinant Human LIF Protein CHO-K1
Human LIF-30H Active Recombinant Human LIF Protein (Carrier Free-Ready-to-Use, 181 amino acid) E.coli 181 amino acid
Human LIF-22H Recombinant Human LIF protein E.coli N/A 180
Human LIF-406H Recombinant Human LIF, Fc tagged Human Cell His
Human LIF-328H Recombinant Human LIF protein HEK293 Ser23-Phe202
Human LIF-217H Recombinant Human LIF, StrepII-tagged Human Cell Strep II 23-202, 180 a.a.
Human LIF-419H Recombinant Human LIF, His tagged Human Cell Fc
Human LIF-472H Recombinant Human LIF, His-GST E.coli His/GST
Human LIF-1071HCL Recombinant Human LIF cell lysate Human Cell N/A
Human LIF-527H Recombinant Human LIF Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LIF-301508H Recombinant Human LIF protein, GST-tagged E.coli GST Ile27-Phe202
Human LIF-4343HG Active GMP Recombinant Human LIF protein E.coli N/A
Human LIF-26H Recombinant Human LIF Protein E.coli
Human LIF-436HG Active GMP Recombinant Human LIF protein HEK293 DNA sequence encoding Human LIF(NP_002300.1) was expressed with His tag at the C-terminal.
Human LIF-206H Active Recombinant Human LIF Protein E.coli
Human LIF-420H Active Recombinant Human LIF protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser23-Phe202
Human LIF-39H Active Recombinant Human LIF Protein E.coli
Human LIF-1814HFL Recombinant Full Length Human LIF Protein, C-Flag-tagged Mammalian cells Flag
Human LIF-101H Active Recombinant Human LIF Protein E.coli
Human LIF-231H Recombinant Active Human LIF Protein, His-tagged(C-ter) HEK293 His(C-ter) Ser23-Phe202
Human LIF-02H Recombinant Human LIF Protein, His-tagged HEK293 His
Human LIF-1292H Recombinant Human LIF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LIF-341L Active Recombinant Human LIF Protein (180 aa) E.coli 180
Human LIF-11H Recombinant Human LIF Protein, His-tagged HEK293 His
Human LIF-519H Recombinant Human LIF Protein 202
Human LIF-29H Active Recombinant Human LIF Protein (Animal Free-Ready-to-Use, 181 amino acid) E.coli 181 amino acid
Human LIF-248H Recombinant Human LIF protein, hFc-tagged HEK293 hFc Ser23-Phe202
Human LIF-1292H-B Recombinant Human LIF Protein Pre-coupled Magnetic Beads HEK293
Human LIF-4444H Recombinant Human LIF Protein (Pro24-Phe202), N-His tagged E.coli N-His Pro24-Phe202
Human LIF-0330H Active Recombinant Human LIF protein(Met1-Phe202) HEK293 N/A Met1-Phe202
Human LIF-2394H Recombinant Human LIF Protein, His-tagged E.coli N-His Lys2-Ala201
Human LIF-162H Recombinant Human LIF Protein, 23AA-202AA, Tag Free, Biotinylated HEK293 Tag Free 23AA-202AA
Human LIF-2031H Active Recombinant Human LIF protein, His-tagged HEK293 His Ser23-Phe202
Human LIF-129H Human Leukaemia Inhibitory Factor(rDNA derived) Reference standard N/A
Human LIF-2623H Active Recombinant Human LIF protein, His-tagged HEK293 His Ser23-Phe202
Human LIF-35H Recombinant Human LIF Protein (Ready-to-Use)
Human LIF-38HG Recombinant Human LIF Protein, GMP Grade, Animal-Free E.coli 180 amino acids residues, including three disulfide bonds
Human LIF-211H Active Recombinant Human LIF Protein (Ser23-Phe202), N-His tagged, Animal-free, Carrier-free E.coli N-His Ser23-Phe202
Mouse Lif-8869M Active Recombinant Mouse LIF,His-tagged Hordeum Vulgare N/A
Mouse Lif-10M Active Recombinant mouse LIF Hordeum Vulgare N/A
Mouse Lif-719M Active Recombinant Mouse Lif, His-tagged, Biotinylated Human Cell His
Mouse Lif-31M Active Recombinant Mouse Lif, His-tagged Barley Grain His
Mouse Lif-720M Active Recombinant Mouse Lif, Fc-tagged, Biotinylated Human Cell Fc
Mouse LIF-01M Active Recombinant Mouse LIF Protein, His-Tagged E.coli His
Mouse Lif-521M Active Recombinant Mouse Lif protein HEK293 N/A Met1-Phe203
Mouse Lif-757M Active Recombinant Mouse Lif protein, His-tagged HEK293 His Met1-Phe203
Mouse Lif-556M Recombinant Mouse Lif protein E.coli N/A 180
Mouse Lif-23M Recombinant Mouse Leukemia Inhibitory Factor E.coli N/A
Mouse Lif-756M Recombinant Mouse Lif, Fc tagged Human Cell Fc
Mouse Lif-679M Recombinant Mouse Lif protein, His-tagged E.coli His Pro25~Phe203 (Accession# P09056)
Mouse LIF-1729MCL Recombinant Mouse LIF cell lysate Human Cell N/A
Mouse Lif-32M Active Recombinant Mouse Lif Protein (Animal Free-Ready-to-Use, 181 amino acid) E.coli 181 amino acid
Mouse Lif-123M Active Recombinant Mouse Lif Protein E.coli
Mouse Lif-27M Active Recombinant Mouse Lif Protein, Pre-aliquoted E.coli Pro25-Phe203
Mouse Lif-65M Active Recombinant Mouse Lif Protein (Ser24-Phe203), N-His tagged, Animal-free, Carrier-free E.coli N-His Ser24-Phe203
Mouse Lif-340L Active Recombinant Mouse Lif Protein (180 aa) E.coli 180
Mouse Lif-1317M Recombinant Mouse Lif Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse LIF-207M Active Recombinant Mouse LIF Protein E.coli
Mouse Lif-57M Active Recombinant Mouse Lif Protein E.coli
Mouse Lif-122M Recombinant Mouse Lif Protein E.coli
Mouse Lif-7267M Active Recombinant Mouse Lif Protein E.coli
Mouse Lif-043L Active Recombinant Mouse Lif Protein (181 aa) E.coli 181
Mouse Lif-25M Recombinant Mouse Lif Protein E.coli
Mouse LIF-520M Recombinant Mouse LIF Protein 203
Mouse Lif-4058M Recombinant Mouse Lif Protein (Pro25-Phe203), C-His tagged Mammalian cells C-His Pro25-Phe203
Mouse Lif-33M Active Recombinant Mouse Lif Protein (Ready-to-Use, 181 amino acid) E.coli 181 amino acid
Rat Lif-379R Active Recombinant Rat Leukemia Inhibitory Factor, GST-tagged E.coli GST
Rat Lif-733R Recombinant Rat Lif protein E.coli N/A 180
Rat LIF-2202R Recombinant Rat LIF protein, His-tagged HEK293 His Ser 23 - Phe 202
Rat Lif-1739R Recombinant Rat Lif Protein, His-tagged E.coli N-His Leu25-Phe202
Dog LIF-677D Recombinant Dog LIF protein, His & T7-tagged E.coli His/T7 Leu25~Ala196 (Accession # J9NRL6)
Cattle LIF-2753C Recombinant Cattle LIF Protein, His-tagged HEK293F N-His Ser23-Ala196
Chicken LIF-4404C Recombinant Chicken LIF Protein Yeast N/A 187aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIF Related Articles
  • LIF Related Gene Family
  • LIF Related Research Area

LIF involved in several pathways and played different roles in them. We selected most pathways LIF participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionBMPR1B;CCR6;IFNA16;PRLR;GHR;CCR1;CCL28;CCL3;EDA
Signaling pathways regulating pluripotency of stem cellsSKIL;RAF1;APC;ISL1;SMAD9;ACVR2A;SETDB1;SMAD3;NEUROG1
Jak-STAT signaling pathwayIL21R;STAM;GH1;FHL1;IL10RB;FHL1A;SOCS6;TP-1;PTPN11A
TNF signaling pathwayMAPK1;MLKL;MAP2K6;MAPK9;FAS;IL15;CCL20;ICAM1;CXCL1

LIF has several biochemical functions, for example, cytokine activity, growth factor activity, leukemia inhibitory factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIF itself. We selected most functions LIF had, and list some proteins which have the same functions with LIF. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCTF1;IL32;IFNA13;IL1F10;TNFSF8;GREM2;IL17A/F2;TNFRSF11B;CMTM8
growth factor activityVHL;BMP15;HBEGFA;SPAW;VEGFA;CECR1A;ENDOU;THBS4B;PRL2C3
leukemia inhibitory factor receptor bindingCtf2;CTF1;LIF
receptor bindingTRIM24;FGF8A;JAK2;CADM1A;ARPP19;Ren1;PTK6;LRRC4B;LBP
transcription factor activity, RNA polymerase II transcription factor recruitingNCOA3;LIF

LIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIF here. Most of them are supplied by our site. Hope this information will be useful for your research of LIF.

IL6ST; LIFR

Levy, YA; Mausner-Fainberg, K; et al. Dysregulated production of leukemia inhibitory factor in immune cells of relapsing remitting multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY 278:85-89(2015).
Leung, SJ; Rice, PS; et al. In Vivo Molecular Mapping of the Tumor Microenvironment in an Azoxymethane-Treated Mouse Model of Colon Carcinogenesis. LASERS IN SURGERY AND MEDICINE 47:40-49(2015).
IL
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