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Official Full Name leukemia inhibitory factor
Background LIF (Leukocyte inhibitory factor) is produced by various fibroblast cell lines, antigen-stimulated alloreactive T-lymphocytes, mitogen-activated spleen cells, and Krebs and Ehrlich ascites cells. It is also produced by monocytes after cell activation. This factor inhibits the random and directed migration of polymorphonuclear (PMN) leukocytes. LIF also induces specific granule secretion by PMNs and potentiates many responses mediated by the chemotactic compound fMLP (formyl-methionyl-leucyl-phenylalanine). It activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes.
Synonyms LIF; leukemia inhibitory factor; CDF; cholinergic differentiation factor; DIA; differentiation inhibitory activity; differentiation inducing factor; hepatocyte stimulating factor III; HILDA; human interleukin in DA cells; D factor; melanoma-derived LPL inhibitor; differentiation-inducing factor; hepatocyte-stimulating factor III; differentiation-stimulating factor; MLPLI
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Rat
    • Source :
    • Barley Grain
    • E.coli
    • HEK293
    • HEK293T
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • Avi
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LIF-301508H Recombinant Human LIF protein, GST-tagged E.coli GST
    Human LIF-1071HCL Recombinant Human LIF cell lysate Human Cell N/A
    Human LIF-129H Human Leukaemia Inhibitory Factor(rDNA derived) Reference standard N/A
    Human LIF-134H Recombinant Human LIF protein, His-tagged Insect Cell His
    Human LIF-167H Recombinant Human LIF Protein, Biotinylated E.coli N/A
    Human LIF-2031H Recombinant Human LIF Protein, His-tagged HEK293 His
    Human LIF-217H Recombinant Human LIF, StrepII-tagged Human Cell Strep II
    Human LIF-22H Recombinant Human LIF protein E.coli N/A
    Human LIF-328H Recombinant Human LIF protein HEK293
    Human LIF-378H Recombinant Human leukemia Inhibitory Factor HEK293 N/A
    Human LIF-406H Recombinant Human LIF, Fc tagged Human Cell His
    Human LIF-419H Recombinant Human LIF, His tagged Human Cell Fc
    Human LIF-420H Recombinant Human LIF Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human LIF-4343HG GMP Recombinant Human LIF protein E.coli N/A
    Human LIF-436HG GMP Recombinant Human LIF protein, His-tagged HEK293 His
    Human LIF-472H Recombinant Human LIF, His-GST E.coli His/GST
    Human LIF-514H Recombinant Human LIF E.coli N/A
    Human LIF-527H Recombinant Human LIF Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human LIF-634H Recombinant Human LIF, His-tagged, Biotinylated Human Cell His
    Human LIF-635H Recombinant Human LIF, Fc-tagged, Biotinylated Human Cell Fc
    Human LIF-8868H Recombinant Human LIF, His-tagged Hordeum Vulgare N/A
    Mouse Lif-10M Recombinant mouse LIF Hordeum Vulgare N/A
    Mouse Lif-122M Recombinant Mouse Lif Protein E.coli
    Mouse Lif-123M Recombinant Mouse Lif Protein E.coli
    Mouse Lif-1317M Recombinant Mouse Lif Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse LIF-1729MCL Recombinant Mouse LIF cell lysate Human Cell N/A
    Mouse Lif-23M Recombinant Mouse Leukemia Inhibitory Factor E.coli N/A
    Mouse Lif-31M Recombinant Mouse Lif, His-tagged Barley Grain His
    Mouse Lif-521M Recombinant Mouse Lif Human Cell N/A
    Mouse Lif-556M Recombinant Mouse Lif protein E.coli N/A
    Mouse Lif-679M Recombinant Mouse Lif protein, His-tagged E.coli His
    Mouse Lif-719M Recombinant Mouse Lif, His-tagged, Biotinylated Human Cell His
    Mouse Lif-720M Recombinant Mouse Lif, Fc-tagged, Biotinylated Human Cell Fc
    Mouse Lif-7267M Recombinant Mouse Lif Protein E.coli
    Mouse Lif-756M Recombinant Mouse Lif, Fc tagged Human Cell Fc
    Mouse Lif-757M Recombinant Mouse Lif protein, His-tagged HEK293 His
    Mouse Lif-8869M Recombinant Mouse LIF,His-tagged Hordeum Vulgare N/A
    Rat Lif-379R Recombinant Rat Leukemia Inhibitory Factor, GST-tagged E.coli GST
    Rat Lif-733R Recombinant Rat Lif protein E.coli N/A
    Dog LIF-677D Recombinant Dog LIF protein, His & T7-tagged E.coli His/T7
    Chicken LIF-4404C Recombinant Chicken LIF Protein Yeast N/A

    LIF involved in several pathways and played different roles in them. We selected most pathways LIF participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CNTF; CXCR3.2; IFNK; TNFRSF10D; TNFRSF21; GHR; CSF3R; IL1B; CCR5; BMP7A
    Signaling pathways regulating pluripotency of stem cells IGF1R; WNT5A; AXIN2; PCGF1; PCGF2; MAPK3; ZIC3; FGFR1; WNT7B; OTX1
    Jak-STAT signaling pathway IL3; MPL; IL15RA; AKT2L; IL11RA; GRB2A; IFNAR1; GFAP; AKT3A; PIK3CB
    TNF signaling pathway CFLAR; CREB3L1; IL15; CREB3L3; MLKL; IKBKG; BCL3; TRADD; CX3CL1; BIRC2

    LIF has several biochemical functions, for example, cytokine activity, growth factor activity, leukemia inhibitory factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIF itself. We selected most functions LIF had, and list some proteins which have the same functions with LIF. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity HMGB1B; TNFSF13B; TNFSF15; IFNA5; SECTM1; IFNA4; IL19; BMP6; IL11; TNFSF8
    growth factor activity FGF18B; LEP; TDGF1; NDR1; BTC; NDR2; FGF13A; TGFB2; DKK1; GDF6
    leukemia inhibitory factor receptor binding Ctf2; CTF1; LIF
    receptor binding WNT4A; NRG2A; IL29; PTK2; FZD8; TNFSF15; PPY; ASIP; NRG4; CDH5
    transcription factor activity, RNA polymerase II transcription factor recruiting LIF; NCOA3

    LIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIF here. Most of them are supplied by our site. Hope this information will be useful for your research of LIF.


    Levy, YA; Mausner-Fainberg, K; et al. Dysregulated production of leukemia inhibitory factor in immune cells of relapsing remitting multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY 278:85-89(2015).
    Leung, SJ; Rice, PS; et al. In Vivo Molecular Mapping of the Tumor Microenvironment in an Azoxymethane-Treated Mouse Model of Colon Carcinogenesis. LASERS IN SURGERY AND MEDICINE 47:40-49(2015).


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