LRP2

Official Full Name

low density lipoprotein receptor-related protein 2
Overview

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
Synonyms

LRP2; low density lipoprotein receptor-related protein 2; low-density lipoprotein receptor-related protein 2; DBS; gp330; megalin; LRP-2; glycoprotein 330; calcium sensor protein; Heymann nephritis antigen homolog;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LRP2-27H	Recombinant Human LRP2 Protein, His-tagged	E.coli	His	Gly4035~Leu4184	$298 / 10μg
Human	LRP2-7443H	Recombinant Human LRP2 protein, His-tagged	Yeast	C-His	1186-1389aa	Inquiry
Human	LRP2-1448H	Recombinant Human LRP2 Protein (1186-1389 aa), His-tagged	Yeast	His	1186-1389 aa	Inquiry
Human	LRP2-2811H	Recombinant Human LRP2 protein(4531-4600 aa), C-His-tagged	E.coli	His	4531-4600 aa	Inquiry
Human	LRP2-8754H	Recombinant Human LRP2 protein, mFc-tagged	HEK293	C-mFc	1186-1389aa	Inquiry
Mouse	LRP2-9234M	Recombinant Mouse LRP2 Protein	Mammalian Cell	His		Inquiry
Mouse	LRP2-5162M	Recombinant Mouse LRP2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	LRP2-5162M-B	Recombinant Mouse LRP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	LRP2-3453R	Recombinant Rat LRP2 Protein	Mammalian Cell	His		Inquiry
Rat	LRP2-3109R-B	Recombinant Rat LRP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	LRP2-3109R	Recombinant Rat LRP2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

LRP2 involved in several pathways and played different roles in them. We selected most pathways LRP2 participated on our site, such as Hedgehog signaling pathway, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog signaling pathway	ZIC2A;WNT1;GLI2B;SHHA;SMO;BMP2;ZIC2B;Shh;DYRK1AA
Thyroid hormone synthesis	DUOXA2;SLC26A4;GPX1;GPX3;PDIA4;CREB3L3;SLC5A5;CREB3L1;TSHR

LRP2 has several biochemical functions, for example, PDZ domain binding, SH3 domain binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP2 itself. We selected most functions LRP2 had, and list some proteins which have the same functions with LRP2. You can find most of the proteins on our site.

Function	Related Protein
PDZ domain binding	PDZK1;ATP2B1;LNX1;DTNA;GRM7;GRIK5;SLC26A6;CXXC4;DLG4
SH3 domain binding	ADAM15;EVL;EFS;GRIK5;CABYR;QKI;SHANK1;LANCL1;DPYSL3
calcium ion binding	NDUFAB1;CBLC;SPNA1;PLSCR4;MGMT;CDK5R1;PLSCR1;VSNL1A;PADI3
hemoglobin binding	CUBN;HBB;AHSP;HP;LRP2;HPR
hormone binding	CALR;NPR2;NPR1;MC5R;LRP2;MC1R;UCN2;TTR;ADIPOR1B
contributes_to lipoprotein transporter activity
low-density lipoprotein particle receptor binding	DNAJA1;LDLRAP1;HSP90B1;APOB;CCDC167;SYT1;PCSK9;CRP;LRP2
metal ion binding	ZFP689;AMY1A;ZFP516;ZNF581;ZNF222;CAPN8;KDM5BB;GDPD1;GTF3AB
protein binding	CRYBA1;TRAPPC6A;TRAPPC4;GRID2IP;TBL3;IK;RAC1;MYOM1;SMAD1
protein complex binding	CALY;CAV3;HTR2A;MTAP1B;TUB;DRD1;OTOF;CASP8;PPP2R2A
receptor activity	ANTXR2B;ADIPOR1B;CADM1A;TNFRSF13B;TNFRSF17;VMN1R49;CADM2;CD200R3;ITGB4

LRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP2.

Dab1; Dlg4; Synj2bp; Mapk8ip2; Mapk8ip1; Gipc1; Gm10174; Anapc10; Ywhaz; Hsd3b4; Rpgrip1l

Research Area

Uptake and Transport Molecules in VSMC

Pieper-Furst, U; Hall, R; et al. Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1812:1640-1648(2011).

Fujiyoshi, M; Tachikawa, M; et al. Amyloid-beta peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. JOURNAL OF NEUROCHEMISTRY 118:407-415(2011).