|Official Full Name||low density lipoprotein receptor-related protein 2|
|Background||The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).|
|Synonyms||LRP2; low density lipoprotein receptor-related protein 2; low-density lipoprotein receptor-related protein 2; DBS; gp330; megalin; LRP-2; glycoprotein 330; calcium sensor protein; Heymann nephritis antigen homolog|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
LRP2 involved in several pathways and played different roles in them. We selected most pathways LRP2 participated on our site, such as Hedgehog signaling pathway, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Hedgehog signaling pathway||FBXW11; WNT11R; WNT5B; CSNK1G3; SKI; WNT1; PRKACG; ZIC2A; WNT2BA; WNT11B|
|Thyroid hormone synthesis||TPO; HSP90B1; Adcy4; ATP1B4; ATP1A3; GPX8; PRKCG; GPX1; TTF2; ATF4|
LRP2 has several biochemical functions, for example, PDZ domain binding, SH3 domain binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP2 itself. We selected most functions LRP2 had, and list some proteins which have the same functions with LRP2. You can find most of the proteins on our site.
|PDZ domain binding||LRP2; ERC1; SLC26A6; KIDINS220; DLC; DOCK4; ACOX1; GNG5; ARHGEF16; ATP2B1A|
|SH3 domain binding||FUT8; KHDRBS2; HCLS1; ADAM9; ELMO1; SH3BGRL; PARK2; QK; VASP; FMNL3|
|calcium ion binding||KCNIP3; PCDH2G9; JAG1A; PROC; EFHD2; CALR; PLS3; PITPNM2; STIM1; PCDH1G2|
|hemoglobin binding||HP; AHSP; LRP2; CUBN; HBB; HPR|
|hormone binding||MC1R; ADIPOR2; AMHR2; LRP2; NPR3; NPR2; CRYM; ADIPOR1B; NPR1; GPR30|
|contributes_to lipoprotein transporter activity||LRP2|
|low-density lipoprotein particle receptor binding||CCDC167; DNAJA1; LDLRAP1; APOEB; ARRB2; APOEA; APOA5; SACS; MMP13; SYT1|
|metal ion binding||UNK; ARMC1; RORCA; ZNF358; CYB561D1; THAP8; TOE1; CYP4A10; CSH1; PRKCBB|
|protein binding||KCNG4; RBPMS; KRTAP19-7; DIABLO; GIT1; SUPT5H; CCNA1; GOLPH3; CREBBP; NRBP1|
|protein complex binding||RBM10; ABI2; CRTAP; GRIN2A; Ctsl; PGAM5; NR0B2; TRAF2; FYB; DISC1|
|receptor activity||NR2C1; CD46; ANTXR2A; TREM1; JMJD6; LILRB3; NPY2R; OGFRL1; CSF3R; ITGB3B|
LRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP2.
Dab1; Dlg4; Synj2bp; Mapk8ip2; Mapk8ip1; Gipc1; Gm10174; Anapc10; Ywhaz; Hsd3b4; Rpgrip1l