LRP2 Protein


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Official Full Name low density lipoprotein receptor-related protein 2
Background The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
Synonyms LRP2; low density lipoprotein receptor-related protein 2; low-density lipoprotein receptor-related protein 2; DBS; gp330; megalin; LRP-2; glycoprotein 330; calcium sensor protein; Heymann nephritis antigen homolog
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LRP2-1448H Recombinant Human LRP2 Protein (1186-1389 aa), His-tagged Yeast His
    Human LRP2-27H Recombinant Human LRP2 Protein, His-tagged E.coli His
    Mouse LRP2-9234M Recombinant Mouse LRP2 Protein Mammalian Cell His
    Rat LRP2-3453R Recombinant Rat LRP2 Protein Mammalian Cell His

    LRP2 involved in several pathways and played different roles in them. We selected most pathways LRP2 participated on our site, such as Hedgehog signaling pathway, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog signaling pathway FBXW11; WNT11R; WNT5B; CSNK1G3; SKI; WNT1; PRKACG; ZIC2A; WNT2BA; WNT11B
    Thyroid hormone synthesis TPO; HSP90B1; Adcy4; ATP1B4; ATP1A3; GPX8; PRKCG; GPX1; TTF2; ATF4

    LRP2 has several biochemical functions, for example, PDZ domain binding, SH3 domain binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP2 itself. We selected most functions LRP2 had, and list some proteins which have the same functions with LRP2. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding LRP2; ERC1; SLC26A6; KIDINS220; DLC; DOCK4; ACOX1; GNG5; ARHGEF16; ATP2B1A
    SH3 domain binding FUT8; KHDRBS2; HCLS1; ADAM9; ELMO1; SH3BGRL; PARK2; QK; VASP; FMNL3
    calcium ion binding KCNIP3; PCDH2G9; JAG1A; PROC; EFHD2; CALR; PLS3; PITPNM2; STIM1; PCDH1G2
    hemoglobin binding HP; AHSP; LRP2; CUBN; HBB; HPR
    hormone binding MC1R; ADIPOR2; AMHR2; LRP2; NPR3; NPR2; CRYM; ADIPOR1B; NPR1; GPR30
    contributes_to lipoprotein transporter activity LRP2
    low-density lipoprotein particle receptor binding CCDC167; DNAJA1; LDLRAP1; APOEB; ARRB2; APOEA; APOA5; SACS; MMP13; SYT1
    metal ion binding UNK; ARMC1; RORCA; ZNF358; CYB561D1; THAP8; TOE1; CYP4A10; CSH1; PRKCBB
    protein binding KCNG4; RBPMS; KRTAP19-7; DIABLO; GIT1; SUPT5H; CCNA1; GOLPH3; CREBBP; NRBP1
    protein complex binding RBM10; ABI2; CRTAP; GRIN2A; Ctsl; PGAM5; NR0B2; TRAF2; FYB; DISC1
    receptor activity NR2C1; CD46; ANTXR2A; TREM1; JMJD6; LILRB3; NPY2R; OGFRL1; CSF3R; ITGB3B

    LRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP2.

    Dab1; Dlg4; Synj2bp; Mapk8ip2; Mapk8ip1; Gipc1; Gm10174; Anapc10; Ywhaz; Hsd3b4; Rpgrip1l

    Pieper-Furst, U; Hall, R; et al. Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1812:1640-1648(2011).
    Fujiyoshi, M; Tachikawa, M; et al. Amyloid-beta peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. JOURNAL OF NEUROCHEMISTRY 118:407-415(2011).

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