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Official Full Name low density lipoprotein receptor-related protein 6
Background LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain,
Synonyms LRP6; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; ADCAD2; FLJ90062; FLJ90421
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • His
    • Mouse
    • IgG
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LRP6-1040H Recombinant Human LRP6 Protein, Fc Chimera Mammalian cells Fc
    Human LRP6-4654HCL Recombinant Human LRP6 293 Cell Lysate HEK293 N/A
    Human LRP6-552H Recombinant Human LRP6 protein, Mouse IgG Fc-tagged HEK293 Mouse/IgG/Fc
    Human LRP6-7875H Recombinant Human LRP6 protein, His-tagged E.coli His
    Mouse Lrp6-1051M Recombinant Mouse Lrp6 Protein, His-tagged Mammalian cells His
    Mouse Lrp6-1338M Recombinant Mouse Lrp6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse LRP6-9239M Recombinant Mouse LRP6 Protein Mammalian Cell His
    Rhesus Macaque LRP6-2552R Recombinant Rhesus monkey LRP6 Protein, His-tagged Mammalian Cell His
    Zebrafish LRP6-7173Z Recombinant Zebrafish LRP6 Mammalian Cell His

    LRP6 involved in several pathways and played different roles in them. We selected most pathways LRP6 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway LRP5; WNT1; PPP3CCA; PPP3R1; RHOAD; CXXC4; TCF7L2; WNT11B; APC; FZD3B

    LRP6 has several biochemical functions, for example, Wnt-activated receptor activity, Wnt-protein binding, apolipoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP6 itself. We selected most functions LRP6 had, and list some proteins which have the same functions with LRP6. You can find most of the proteins on our site.

    Function Related Protein
    Wnt-activated receptor activity FZD3B; FZD7; FZD1; FZD2; LRP5L; FZD10; FZD8B; FZD8; FZD7B; FZD7A
    Wnt-protein binding FRZB; SFRP2; FZD6; FZD7; FZD2; FZD9B; FZD8B; Fzd4; LRP2A; FZD5
    apolipoprotein binding LIPC; ABCA1; MAPT; LRP1; PCSK9; CANX; LRP4; PLG; LPA; LPL
    coreceptor activity involved in Wnt signaling pathway LRP6
    frizzled binding WNT8A; WNT2BB; WNT1; WNT7B; SFRP1; FZD7; WNT7AA; WNT10B; DVL1B; RSPO3
    identical protein binding TARDBP; TNK2; DPY30; P2RX2; HCN4; SEPHS1; RABAC1; BAX; ASMT; ACY3
    kinase inhibitor activity SOCS1; RHOH; AHSG; LRP6
    low-density lipoprotein receptor activity VLDLR; OLR1; LRP12; LDLR; LRP6; CXCL16
    protein binding RABL2A; MPP5; SENP5; TGFBR2; TCEAL5; UGGT2; BMPR1B; NFATC3; IL17RA; RPL4
    protein homodimerization activity BHLHB9; EVLA; TESC; BAXA; CASQ2; DEM1; MTPAP; PDE2A; RAB11FIP4B; XBP1
    receptor binding HNF4A; ARPP19; FYNB; GRP; HSPA1A; CCDC129; NRG2B; DHRS4; ARPP19A; GBA
    toxin transporter activity SLC7A8; ABCG1; SLC17A3; LRP6; SLC22A2; SLC22A3
    NOT toxin transporter activity LRP5; LRP6

    LRP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP6.

    Fzd8; GSK3B; Axin1

    Tella, SH; Gallagher, JC; et al. Biological agents in management of osteoporosis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 70:1291-1301(2014).
    Qian, LL; Cai, CZ; et al. Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. SCIENCE CHINA-LIFE SCIENCES 57:469-481(2014).

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