MAP3K3

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 3

  • Overview

    MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2 (1,2). MEKK3 also stimulates MEK5 via activation of ERK5/
  • Synonyms

    MAP3K3; mitogen-activated protein kinase kinase kinase 3; MEKK3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; MEKK 3; MEK kinase 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K3-735H Recombinant Human MAP3K3 Protein, His-tagged E.coli His
Human MAP3K3-30192TH Recombinant Human MAP3K3 N/A
Human MAP3K3-352H Recombinant Human MAP3K3, GST-tagged, Active Sf9 Insect Cell GST
Human MAP3K3-1259H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged Insect Cell GST
Human MAP3K3-4505HCL Recombinant Human MAP3K3 293 Cell Lysate HEK293 N/A
Human MAP3K3-2492H Recombinant Human MAP3K3 protein, His-tagged E.coli His
Human MAP3K3-9152HF Active Recombinant Full Length Human MAP3K3 Protein, GST-tagged Insect (sf21) GST
Rhesus Macaque MAP3K3-2669R Recombinant Rhesus monkey MAP3K3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAP3K3-2489R Recombinant Rhesus Macaque MAP3K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAP3K3-2489R-B Recombinant Rhesus Macaque MAP3K3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP3K3 Related Articles
  • MAP3K3 Related Research Area
  • MAP3K3 Related Signal Pathway

MAP3K3 involved in several pathways and played different roles in them. We selected most pathways MAP3K3 participated on our site, such as MAPK signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayHRASB;Fgf15;HSC70;ARRB2;GNG12;MAP3K14;PRKCB;Pdgfa&Pdgfb;GADD45AB
Neurotrophin signaling pathwayPRKCD;PIK3CB;MAPK8;NTRK2;NGFR;ATF4;MAPK3;RAC1;PIK3CD
GnRH signaling pathwayCDC42L2;SRC;EGFRA;MAP2K6;LHBETA1;CAMK2D1;CALM2A;PRKACBA;MAPK12B
HTLV-I infectionTBP;TRP53INP1;TBPL2;CD40;H2-AA;LTBR;CD3D;KAT2B;VCAM1

MAP3K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K3 itself. We selected most functions MAP3K3 had, and list some proteins which have the same functions with MAP3K3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingOXSR1A;NEK7;AK4;HELLS;CLK3;CHORDC1;P2RY1;MYH4;RUVBL2
MAP kinase kinase kinase activityMAP3K4;MAP3K13;EGFR;TAOK2;KIAA1804;MAP3K15;TAOK1;MAP3K6;TAOK3
metal ion bindingMTHFS;SP7;PDLIM3A;FDPS;PRDM10;CTDSP2;ANKIB1A;ACLY;ALKBH7
protein bindingC5orf24;C19orf46;NQO2;ELF1;NDUFS3;ATL1;LRRC3;IFT88;TYRO3
protein kinase activityRIPK4;PDK1;MAPK8B;TGFBR1;PAK1;NEK1;CHUK;PHKG1B;NTRK2B

MAP3K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K3.

YWHAE; TRAF7; CHUK; FLNA; MAP2K5; YWHAB; YWHAE

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
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