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MAP3K3

Official Full Name

mitogen-activated protein kinase kinase kinase 3
Overview

MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2 (1,2). MEKK3 also stimulates MEK5 via activation of ERK5/
Synonyms

MAP3K3; mitogen-activated protein kinase kinase kinase 3; MEKK3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; MEKK 3; MEK kinase 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

E.coli
HEK293
Insect (sf21)
Insect Cell
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP3K3-735H	Recombinant Human MAP3K3 Protein, His-tagged	E.coli	His		Inquiry
Human	MAP3K3-30192TH	Recombinant Human MAP3K3		N/A		Inquiry
Human	MAP3K3-352H	Recombinant Human MAP3K3, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	MAP3K3-1259H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged	Insect Cell	GST		Inquiry
Human	MAP3K3-4505HCL	Recombinant Human MAP3K3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MAP3K3-2492H	Recombinant Human MAP3K3 protein, His-tagged	E.coli	His	281-366 aa	$319 / 25ug
Human	MAP3K3-9152HF	Active Recombinant Full Length Human MAP3K3 Protein, GST-tagged	Insect (sf21)	GST	1-626	Inquiry
Rhesus Macaque	MAP3K3-2669R	Recombinant Rhesus monkey MAP3K3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MAP3K3-2489R	Recombinant Rhesus Macaque MAP3K3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MAP3K3-2489R-B	Recombinant Rhesus Macaque MAP3K3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
MAP3K3 Related Signal Pathway

MAP3K3 involved in several pathways and played different roles in them. We selected most pathways MAP3K3 participated on our site, such as MAPK signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	GNA12A;IL1R1;PRKCBA;RAF1B;PPP3CCB;TGFB2;MAPK7;ATF4B1;LRRK2
Neurotrophin signaling pathway	PIK3CB;BAD;FOXO3;SHC1;PIK3CG;MAP3K3;CAMK2D;NTRK3;PSEN2
GnRH signaling pathway	MMP14;MAPK7;GNRHR;PRKACBA;PLA2G4A;CDC42L;GNRHR4;PTK2BB;ITPR3
HTLV-I infection	RAN;CDC20;VAC14;HLA-A;PIK3R3;HLA-DRB1;IL1R1;PTTG1;LTA

MAP3K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K3 itself. We selected most functions MAP3K3 had, and list some proteins which have the same functions with MAP3K3. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DYRK3;UBA7;NEK10;FYN;SMARCA4;AXL;CCT3;SRPK1;CAMK2D2
MAP kinase kinase kinase activity	MAP3K12;KIAA1804;MAP3K13;STK3;MAP3K14;YSK4;MAP3K15;MAP3K5;ALPK2
metal ion binding	PHLPP1;PFKM;FAM164A;IMPDH1B;ZNF23;ZFP654;RNF187;MAT2AL;ZFP64
protein binding	STARD3;TRIM24;CAP2;PIK3R6;CCDC28A;SETD6;TTLL6;RALGDS;DUSP9
protein kinase activity	PRKCDA;CASKA;CSNK1G3;PKN1;ERBB4A;RASSF2;STK3;FGFR1B;VSIG8B

MAP3K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K3.

YWHAE; TRAF7; CHUK; FLNA; MAP2K5; YWHAB; YWHAE

Research Area

Kinases and Phosphatases in Endothelial Cells

Post-translational Modification of NFkB/IkB

Intracellular Kinases in the Akt Pathway

MAP3K

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).

Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).