MAP3K3
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Official Full Name
mitogen-activated protein kinase kinase kinase 3 -
Overview
MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2 (1,2). MEKK3 also stimulates MEK5 via activation of ERK5/ -
Synonyms
MAP3K3;mitogen-activated protein kinase kinase kinase 3;MEKK3;MAP/ERK kinase kinase 3;MAPK/ERK kinase kinase 3;MAPKKK3;MEKK 3;MEK kinase 3
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Insect Cells
- Mammalian Cells
- Sf9 Cells
- HEK293
- Sf21 Cells
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAP3K3-2492H | Recombinant Human MAP3K3 protein, His-tagged | E.coli | Human | His | ||
| MAP3K3-1259H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged | Insect Cells | Human | GST | Full L. |
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| MAP3K3-2669R | Recombinant Rhesus monkey MAP3K3 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MAP3K3-30192TH | Recombinant Human MAP3K3 | Human | Non |
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| MAP3K3-352H | Recombinant Human MAP3K3, GST-tagged, Active | Sf9 Cells | Human | GST |
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| MAP3K3-735H | Recombinant Human MAP3K3 Protein, His-tagged | E.coli | Human | His |
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| MAP3K3-4505HCL | Recombinant Human MAP3K3 293 Cell Lysate | HEK293 | Human | Non |
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| MAP3K3-2489R | Recombinant Rhesus Macaque MAP3K3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| MAP3K3-2489R-B | Recombinant Rhesus Macaque MAP3K3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| MAP3K3-9152HF | Active Recombinant Full Length Human MAP3K3 Protein, GST-tagged | Sf21 Cells | Human | GST | Full L. 1-626 |
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Involved Pathway
MAP3K3 involved in several pathways and played different roles in them. We selected most pathways MAP3K3 participated on our site, such as MAPK signaling pathway,Neurotrophin signaling pathway,GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAP2K2A,TGFBR1A,RASGRP3,STMN1,CDC42L2,PPM1A,PPP3CC,RPS6KA6,ARRB2,MAPK14A |
| HTLV-I infection | MYBL2,WNT3A,PIK3CD,STAT5A,VCAM1,APC2,ITGAL,BCL2L1,NFATC1,WNT9A |
| Neurotrophin signaling pathway | NTRK1,PIK3R5,ARHGDIB,SH2B3,BAX,RHOA,ABL1,MAPK11,SH2B2,NGFRAP1 |
| GnRH signaling pathway | GNA11,CAMK2D,RAF1A,GNRHR4,PLD2,PRKCBA,MAP2K4B,MAPK8B,MAP2K2A,MAPK10 |
Protein Function
MAP3K3 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K3 itself. We selected most functions MAP3K3 had, and list some proteins which have the same functions with MAP3K3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase kinase kinase activity | STK3,TAOK2,MAP3K1,MOS,TAOK1,TAOK3,MAP3K5,MAP3K8,KIAA1804,ALPK2 |
| ATP binding | PHKG1,AASDH,STRADB,P2RX1,DDX19B,MAP3K2,GSG2,PRKD1,RPS6KA1,MAPK6 |
| metal ion binding | RC3H2,ZFP553,MGAT4A,FHL2B,COL5A1,PDE12,ZNF280B,RHEBL1,ACVR2B,PDP2 |
| protein binding | SF3B4,HMGN4,FBXO3,SPATA13,LILRB3,RLTPR,TMEM93,PMEPA1,FGF21,MTMR14 |
| protein kinase activity | DYRK1AA,MAP2K2A,CDKL5,OXSR1B,PDK1,RIPK1,RLN1,EGFRA,TEX14,LMTK3 |
Interacting Protein
MAP3K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K3.
YWHAE;TRAF7;CHUK;FLNA;MAP2K5;YWHAB;YWHAE
MAP3K3 Related Signal Pathway
Resources
Research Area
Kinases and Phosphatases in Endothelial CellsIntracellular Kinases in the Akt Pathway
MAP3K
Post-translational Modification of NFkB/IkB
Related Services
Related Products
References
- Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
- Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
