MAPK14 Protein

MAPK14

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MAPK14

Official Full Name mitogen-activated protein kinase 14
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK14; mitogen-activated protein kinase 14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; MAP kinase 14; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; mitogen-activated protein kinase p38 alpha; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • Baculovirus-Insect Cells
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • C-Myc/DDK
    • Fc
    • Flag
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK14-177H Active Recombinant Human MAPK14, Active, His-tagged E.coli His Inquiry
    Human MAPK14-50H Active Recombinant Human MAPK14 protein E.coli N/A Inquiry
    Human MAPK14-550H Active Recombinant Human MAPK14, His-tagged Sf9 Insect Cell His Inquiry
    Human MAPK14-599H Active Recombinant Human MAPK14, GST-tagged Sf9 Insect Cell GST Inquiry
    Human MAPK14-144H Active Recombinant Human MAPK14 protein (Met1-Ser360), His-tagged, activated in vitro Baculovirus-Insect Cells His Inquiry
    Human MAPK14-1046H Recombinant Human Mitogen-Activated Protein Kinase 14, GST-tagged E.coli GST Inquiry
    Human MAPK14-1047H Recombinant Human Mitogen-Activated Protein Kinase 14 E.coli N/A Inquiry
    Human MAPK14-1344H Recombinant Human Mitogen-Activated Protein Kinase 14, His-tagged E.coli His Inquiry
    Human MAPK14-142H Recombinant Human MAPK14, His tagged Insect Cell His Inquiry
    Human MAPK14-178H Recombinant Human MAPK14, Inactive, His-tagged E.coli His Inquiry
    Human MAPK14-25H Recombinant Human MAPK14, GST-tagged, Unactive E.coli GST Inquiry
    Human MAPK14-26H Recombinant Human MAPK14, Unactive E.coli N/A Inquiry
    Human MAPK14-27H Recombinant Human MAPK14(K53A), His-tagged, Unactive E.coli His Inquiry
    Human MAPK14-30539TH Recombinant Human MAPK14 E.coli N/A Inquiry
    Human MAPK14-314H Recombinant Human MAPK14 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human MAPK14-32H Recombinant human biotinylated MAPK14, His-tagged E.coli His Inquiry
    Human MAPK14-356H Recombinant Human MAPK14 protein, His-tagged Insect Cell His Inquiry
    Human MAPK14-372H Recombinant Human MAPK14, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Human MAPK14-474H Recombinant Human MAPK14 Mammalian Cell His Inquiry
    Human MAPK14-5307H Recombinant Human Mitogen-Activated Protein Kinase 14, His-tagged Sf9 Insect Cell His Inquiry
    Human MAPK14-618H Recombinant Human MAPK14, Fc tagged Insect Cell Fc Inquiry
    Human MAPK14-67H Recombinant Human MAPK14 protein, Flag-tagged, Biotinylated Insect Cell Flag Inquiry
    Mouse MAPK14-9530M Recombinant Mouse MAPK14 Protein Mammalian Cell His Inquiry
    Human MAPK14-001HCL Recombinant Human MAPK14 cell lysate Insect Cell N/A Inquiry
    Human MAPK14-1305HFL Recombinant Full Length Human MAPK14 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Rat Mapk14-1762R Recombinant Rat Mapk14 Protein, His-tagged E.coli N-His Inquiry
    Human MAPK14-143H Recombinant Human MAPK14 protein (Met1-Ser360), His-tagged Baculovirus-Insect Cells His Inquiry
    Human MAPK14-365H Recombinant Human MAPK14 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK Inquiry
    Human MAPK14-382H Recombinant Human MAPK14 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human MAPK14-6431H Recombinant Human MAPK14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Mapk14-3941M Recombinant Mouse Mapk14 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Involved Pathway Protein Function Interacting Protein MAPK14 Related Articles

    MAPK14 involved in several pathways and played different roles in them. We selected most pathways MAPK14 participated on our site, such as ADP signalling through P2Y purinoceptor 1, AGE/RAGE pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ADP signalling through P2Y purinoceptor 1 MAPK14; GNB5
    AGE/RAGE pathway AGER; MAPK14; MMP13; CHUK; LGALS3; DIAPH1; JAK2; ATF2; EGFR; DDOST
    ATF-2 transcription factor network CSRP2; JUNB; JDP2; CBFB; JUN; CDK4; RUVBL2; GADD45A; DUSP10; CREB1
    Activated TLR4 signalling PELI2; NOD1; CREB1B; SIGIRR; MAPKAPK2B; APPA; DUSP3; MAPK14; IRAK3; TANK
    Activation of PPARGC1A (PGC-1alpha) by phosphorylation MAPK14
    Activation of the AP-1 family of transcription factors MAPK14; JUN; ATF2
    Adrenergic signaling in cardiomyocytes PPP2R5D; CALM2A; CACNA1DA; PPP2R5E; PLCB2; CALM1B; CALM; CAMK2B; VMHC; ATP2B1A
    Amyotrophic lateral sclerosis (ALS) GRIN2B; PPP3R2; BAD; ALS2; GRIN2D; MAP2K3; PPP3CC; CASP9; CASP1; TNFRSF1A

    MAPK14 has several biochemical functions, for example, ATP binding, MAP kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK14 itself. We selected most functions MAPK14 had, and list some proteins which have the same functions with MAPK14. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SUCLG2; DNAH11; MYO3A; PIK3C2A; STRADA; ACTR2B; ACVR2B; CKMT2B; DCLK1A; VWA8
    MAP kinase activity MAPK14A; MAPK15; MAPK12B; NLK1; MAPK6; MAPK7; MAPK14; MAPK14B; MAPK3; MAPK1
    MAP kinase kinase activity MAP2K2B; ALPK2; MAP3K14; MAP2K2; MAPKAPK5; SBK3; MAPK10; MAP2K2A; MAP3K9; MAP3K20
    NFAT protein binding GATA4; SPI1; MAPK14; FOXP3; PPARA; SFPI1
    enzyme binding EGLN1; NLRP1; PHKG2; HNRNPUL1; CSF3; CYP1A1; CA; UGT1A4; CALU; HDAC2
    protein binding SKIV2L2; TBC1D14; DOT1L; KRTAP12-2; MUTYH; UGP2; CBX3; TRIM39; DNALI1; ZFP36
    protein phosphatase binding DLG3; CSF1R; ANAPC4; HSF4; VCP; Itga10&Itgb1; VRK3; HSP90B1; MAP3K5; GRB2
    protein serine/threonine kinase activity CSNK1E; MASTL; RPS6KAL; STK32B; HIPK3; ACVRL1; AKT3; MAP3K9; DCKL1B; PRKCI

    MAPK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK14.

    MAPKAPK2; MAPKAPK3; SUPT20H; DUSP1

    Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
    Li, W; Li, H; et al. Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway. BIOLOGY OF REPRODUCTION 83:481-487(2010).
    Deshmukh, HS; McLachlan, A; et al. Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:834-845(2009).

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