MAPK14
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Official Full Name
mitogen-activated protein kinase 14
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Overview
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
MAPK14; mitogen-activated protein kinase 14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; MAP kinase 14; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; mitogen-activated protein kinase p38 alpha; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein;
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- Fc
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- His
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- Involved Pathway
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- MAPK14 Related Signal Pathway
MAPK14 involved in several pathways and played different roles in them. We selected most pathways MAPK14 participated on our site, such as ADP signalling through P2Y purinoceptor 1, AGE/RAGE pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ADP signalling through P2Y purinoceptor 1 | GNB5;MAPK14 |
| AGE/RAGE pathway | DDOST;AGER;DIAPH1;MAPK14;MMP13;LGALS3;JUN;ATF2;TIRAP |
| ATF-2 transcription factor network | DUSP5;CDK4;ATF2;KCNA3;CBFB;DUSP10;MAPK14;POU2F1;RUVBL2 |
| Activated TLR4 signalling | PELI2;ATF2;TAB1;TANK;TICAM1;JUN;DHX9;PELI3;SIGIRR |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | |
| Activation of the AP-1 family of transcription factors | ATF2;JUN;MAPK14 |
| Adrenergic signaling in cardiomyocytes | TNNT2;ATP1B1B;GNAI1;PRKACG;CALM2B;PPP2R3C;MYL2;ATP1A1;TNNT2A |
| Amyotrophic lateral sclerosis (ALS) | GRIA2;NEFH;BCL2L1;GRIN2A;GRIA1;MAPK13;TNF;TOMM40L;ALS2 |
MAPK14 has several biochemical functions, for example, ATP binding, MAP kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK14 itself. We selected most functions MAPK14 had, and list some proteins which have the same functions with MAPK14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MCCC1;FASTK;TRIP13;SRPK1B;EHD1;ABL1;ABCD3A;KIF9;TOR1A |
| MAP kinase activity | MAPK1;NLK;MAPK14;MAPK12B;MAPK3;MAPK6;MAPK14B;MAPK8B;MAPK11 |
| MAP kinase kinase activity | MAP2K2A;PAK3;MAPK14;MAP3K14;MAP2K2B;SBK3;MAP2K2;LRRK2;ALPK2 |
| NFAT protein binding | FOXP3;MAPK14;GATA4;PPARA;SPI1;SFPI1 |
| enzyme binding | TAL1;PHKG2;CASP2;KDM1A;VAPB;TRP53;XRCC1;GSTM3;LDB1 |
| protein binding | DCDC2;ALG2;SNCAIP;VRK2;RIPK2;C3orf52;LYVE1;SLC22A5;NOS3 |
| protein phosphatase binding | GNB2L1;EIF2AK3;JUP;DLG4;ANAPC4;PPP6R1;HSF4;DRD1A;CSF1R |
| protein serine/threonine kinase activity | PHKG1B;HIPK4;CDC42BPG;NLK1;BCR;MARK1;HIPK1;SRPK1B;CDK1 |
MAPK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK14.
MAPKAPK2; MAPKAPK3; SUPT20H; DUSP1
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