MAPK14

  • Official Full Name

    mitogen-activated protein kinase 14

  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    MAPK14; mitogen-activated protein kinase 14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; MAP kinase 14; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; mitogen-activated protein kinase p38 alpha; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • Baculovirus-Insect Cells
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • Myc
  • DDK
  • Fc
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK14-177H Active Recombinant Human MAPK14, His-tagged E.coli His
Human MAPK14-550H Active Recombinant Human MAPK14, His-tagged Sf9 Insect Cell His
Human MAPK14-599H Active Recombinant Human MAPK14, GST-tagged Sf9 Insect Cell GST
Human MAPK14-50H Active Recombinant Human MAPK14 protein E.coli N/A
Human MAPK14-144H Active Recombinant Human MAPK14 protein (Met1-Ser360), His-tagged, activated in vitro Baculovirus-Insect Cells His
Human MAPK14-119HFL Active Recombinant Full Length Human MAPK14(T106M) Mutation Protein, N-GST-tagged E.coli GST Full Length
Human MAPK14-120HFL Active Recombinant Full Length Human MAPK14 Protein, N-GST-tagged E.coli GST Full Length
Human MAPK14-121HFL Unactive Recombinant Full Length Human MAPK14 Protein, N-GST-tagged E.coli GST Full Length
Human MAPK14-25H Recombinant Human MAPK14, GST-tagged, Unactive E.coli GST
Human MAPK14-474H Recombinant Human MAPK14 Mammalian Cell His
Human MAPK14-178H Recombinant Human MAPK14, Inactive, His-tagged E.coli His
Human MAPK14-1047H Recombinant Human Mitogen-Activated Protein Kinase 14 E.coli N/A
Human MAPK14-1344H Recombinant Human Mitogen-Activated Protein Kinase 14, His-tagged E.coli His 1-360aa
Human MAPK14-372H Recombinant Human MAPK14, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK14-26H Recombinant Human MAPK14, Unactive E.coli N/A
Human MAPK14-67H Recombinant Human MAPK14 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human MAPK14-5307H Recombinant Human Mitogen-Activated Protein Kinase 14, His-tagged Sf9 Insect Cell His
Human MAPK14-142H Recombinant Human MAPK14 protein(Met1-Ser360), His-tagged Insect Cells N-His Met1-Ser360
Human MAPK14-314H Recombinant Human MAPK14 protein, His/MBP-tagged E.coli His/MBP 119-205 aa
Human MAPK14-618H Recombinant Human MAPK14, Fc tagged Insect Cell Fc
Human MAPK14-30539TH Recombinant Human MAPK14 E.coli N/A
Human MAPK14-356H Recombinant Human MAPK14 protein, His-tagged Insect Cell His
Human MAPK14-32H Recombinant human biotinylated MAPK14, His-tagged E.coli His
Human MAPK14-1046H Recombinant Human Mitogen-Activated Protein Kinase 14, GST-tagged E.coli GST
Human MAPK14-27H Recombinant Human MAPK14(K53A), His-tagged, Unactive E.coli His
Human MAPK14-001HCL Recombinant Human MAPK14 cell lysate Insect Cell N/A
Human MAPK14-6431H Recombinant Human MAPK14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK14-365H Recombinant Human MAPK14 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MAPK14-1362H Recombinant Human MAPK14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAPK14-1305HFL Recombinant Full Length Human MAPK14 Protein, C-Flag-tagged Mammalian cells Flag
Human MAPK14-1362H-B Recombinant Human MAPK14 Protein Pre-coupled Magnetic Beads HEK293
Human MAPK14-1090H Recombinant Human MAPK14 Protein (S2-S360), Tag Free Insect Cell No tag S2-S360
Human MAPK14-382H Recombinant Human MAPK14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAPK14-1091H Recombinant Human MAPK14 Protein (S2-S360), GST tagged Insect Cell GST S2-S360
Human MAPK14-143H Active Recombinant Human MAPK14 protein (Met1-Ser360), His-tagged Baculovirus-Insect Cells His
Mouse MAPK14-9530M Recombinant Mouse MAPK14 Protein Mammalian Cell His
Mouse MAPK14-5346M Recombinant Mouse MAPK14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mapk14-3941M Recombinant Mouse Mapk14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAPK14-5346M-B Recombinant Mouse MAPK14 Protein Pre-coupled Magnetic Beads HEK293
Rat Mapk14-1762R Recombinant Rat Mapk14 Protein, His-tagged E.coli N-His Glu19-Pro279
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAPK14 Related Signal Pathway

MAPK14 involved in several pathways and played different roles in them. We selected most pathways MAPK14 participated on our site, such as ADP signalling through P2Y purinoceptor 1, AGE/RAGE pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ADP signalling through P2Y purinoceptor 1GNB5;MAPK14
AGE/RAGE pathwayDDOST;TIRAP;ATF2;MMP13;DIAPH1;JUN;CHUK;LGALS3;AGER
ATF-2 transcription factor networkDDIT3;ATF2;KAT5;CREB1;GADD45A;HRK;JUNB;DUSP10;RUVBL2
Activated TLR4 signallingMAPKAPK2B;AGER;CHUK;MAP3K8;DHX9;PELI2;TICAM1;SAA1;IRAK3
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of the AP-1 family of transcription factorsJUN;MAPK14;ATF2
Adrenergic signaling in cardiomyocytesMAPK14;TMEM8C;MYH15;CACNG1A;VMHC;PRKACBA;TPM4A;CACNA2D4;CACNB2
Amyotrophic lateral sclerosis (ALS)APAF1;CCS;BAX;TOMM40;PPP3CC;GRIN2B;GRIN2A;CASP12;NEFM

MAPK14 has several biochemical functions, for example, ATP binding, MAP kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK14 itself. We selected most functions MAPK14 had, and list some proteins which have the same functions with MAPK14. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIP6K2;GMPS;SMYHC1;MAPK8B;SRC;NUBP1;PHKG1A;PRKG2;UBA3
MAP kinase activityNLK2;MAPK8A;NLK1;MAPK14B;MAPK8B;MAPK12;MAPK15;MAPK6;MAPK1
MAP kinase kinase activityALPK2;MAP2K1;SBK3;MAP2K7;MAPK10;MAP2K3;MAP2K2B;MAPKAPK5;MAP2K2A
NFAT protein bindingGATA4;FOXP3;PPARA;SPI1;MAPK14;SFPI1
enzyme bindingKMT2E;EIF2AK3;USP22;PARP1;STC2;PDCD2;UGT1A6A;SUDS3;CDC20
protein bindingPRKACA;DCP2;BCAM;MED4;LYL1;GNB1;PASK;CLN6;ASAP3
protein phosphatase bindingPPME1;ITPR1;GNB2L1;ERBB2;FLT4;STAT3;CSK;DRD1A;Itga10&Itgb1
protein serine/threonine kinase activityNEK1;PLK3;IRAK2;NEK5;BMPR2A;BCKDK;NEK9;PAK4;ACVR1

MAPK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK14.

MAPKAPK2; MAPKAPK3; SUPT20H; DUSP1

Research Area

Related articles

Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
Li, W; Li, H; et al. Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway. BIOLOGY OF REPRODUCTION 83:481-487(2010).
Deshmukh, HS; McLachlan, A; et al. Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:834-845(2009).
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