MAPK14 Protein

MAPK14

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MAPK14

Official Full Name mitogen-activated protein kinase 14
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK14; mitogen-activated protein kinase 14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; MAP kinase 14; p38alpha Exip; p38 MAP kinase; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; mitogen-activated protein kinase p38 alpha; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • Baculovirus-Insect Cells
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • C-Myc/DDK
    • Fc
    • Flag
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK14-1046H Recombinant Human Mitogen-Activated Protein Kinase 14, GST-tagged E.coli GST
    Human MAPK14-1047H Recombinant Human Mitogen-Activated Protein Kinase 14 E.coli N/A
    Human MAPK14-1344H Recombinant Human Mitogen-Activated Protein Kinase 14, His-tagged E.coli His
    Human MAPK14-142H Recombinant Human MAPK14, His tagged Insect Cell His
    Human MAPK14-177H Recombinant Human MAPK14, Active, His-tagged E.coli His
    Human MAPK14-178H Recombinant Human MAPK14, Inactive, His-tagged E.coli His
    Human MAPK14-25H Recombinant Human MAPK14, GST-tagged, Unactive E.coli GST
    Human MAPK14-26H Recombinant Human MAPK14, Unactive E.coli N/A
    Human MAPK14-27H Recombinant Human MAPK14(K53A), His-tagged, Unactive E.coli His
    Human MAPK14-30539TH Recombinant Human MAPK14 E.coli N/A
    Human MAPK14-314H Recombinant Human MAPK14 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK14-32H Recombinant human biotinylated MAPK14, His-tagged E.coli His
    Human MAPK14-356H Recombinant Human MAPK14 protein, His-tagged Insect Cell His
    Human MAPK14-372H Recombinant Human MAPK14, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK14-474H Recombinant Human MAPK14 Mammalian Cell His
    Human MAPK14-50H Recombinant Human MAPK14 protein E.coli N/A
    Human MAPK14-5307H Recombinant Human Mitogen-Activated Protein Kinase 14, His-tagged Sf9 Insect Cell His
    Human MAPK14-550H Recombinant Human MAPK14, His-tagged Sf9 Insect Cell His
    Human MAPK14-599H Recombinant Human MAPK14, GST-tagged Sf9 Insect Cell GST
    Human MAPK14-618H Recombinant Human MAPK14, Fc tagged Insect Cell Fc
    Human MAPK14-67H Recombinant Human MAPK14 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse MAPK14-9530M Recombinant Mouse MAPK14 Protein Mammalian Cell His
    Human MAPK14-001HCL Recombinant Human MAPK14 cell lysate Insect Cell N/A
    Rat Mapk14-1762R Recombinant Rat Mapk14 Protein, His-tagged E.coli N-His
    Human MAPK14-143H Recombinant Human MAPK14 protein (Met1-Ser360), His-tagged Baculovirus-Insect Cells His
    Human MAPK14-144H Recombinant Human MAPK14 protein (Met1-Ser360), His-tagged, activated in vitro Baculovirus-Insect Cells His
    Human MAPK14-365H Recombinant Human MAPK14 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK14-382H Recombinant Human MAPK14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAPK14-6431H Recombinant Human MAPK14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk14-3941M Recombinant Mouse Mapk14 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAPK14 involved in several pathways and played different roles in them. We selected most pathways MAPK14 participated on our site, such as ADP signalling through P2Y purinoceptor 1, AGE/RAGE pathway, ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ADP signalling through P2Y purinoceptor 1 MAPK14; GNB5
    AGE/RAGE pathway LGALS3; CHUK; DDOST; JUN; AGER; DIAPH1; TIRAP; ATF2; MAPK14; EGFR
    ATF-2 transcription factor network ATF2; DDIT3; DUSP5; RUVBL2; JUND; CSRP2; JUNB; JDP2; POU2F1; DUSP1
    Activated TLR4 signalling DUSP3B; MAP3K8; SIGIRR; TNIP2; PELI3; APPA; NOD1; TICAM1; CREB1B; IRAK3
    Activation of PPARGC1A (PGC-1alpha) by phosphorylation MAPK14
    Activation of the AP-1 family of transcription factors JUN; MAPK14; ATF2
    Adrenergic signaling in cardiomyocytes ATP1B3A; CREB3L4; CREB3L3; MAPK3; TPM4; PPP2CB; TNNI3; ADRA1D; PPP2CA; PRKCA
    Amyotrophic lateral sclerosis (ALS) TP53; CCS; ALS2; GRIN2C; SOD1; MAP2K3; MAP3K5; MAPK11; PPP3CA; GRIN2A

    MAPK14 has several biochemical functions, for example, ATP binding, MAP kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK14 itself. We selected most functions MAPK14 had, and list some proteins which have the same functions with MAPK14. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding EPHA4; KIF6; SMC6; BRAF; CDKL1; UBE2C; CERK; DDX28; DDX24; ABCE1
    MAP kinase activity MAPK6; MAPK1; MAPK13; MAPK14B; MAPK11; MAPK12; MAPK14; MAPK12A; NLK2; MAPK7
    MAP kinase kinase activity ALPK2; SBK3; MAP2K6; MAPK10; PAK3; MAP3K14; MAP2K2; MAPK14; MAP3K9; LRRK2
    NFAT protein binding PPARA; SFPI1; FOXP3; MAPK14; SPI1; GATA4
    enzyme binding SLPI; TRAF2; HINFP; APOA5; CYP2C19; CYP2C8; USF1; FAM84B; TSPYL1; BIRC5
    protein binding MRAS; DUSP1; GDNF; MC2R; SOX10; SPINK2; RBCK1; GHR; MACROD1; RHOT1
    protein phosphatase binding PPP1R3G; VCAN; MET; LCK; PPME1; RPA3; KAT2A; MVP; SKAP1; STAT3
    protein serine/threonine kinase activity CLK2; ACVR1B; KSR2; TGFBR1A; RIPK3; ULK2; BRAF; MAPK14A; BMPR1AB; RPS6KA5

    MAPK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK14.

    MAPKAPK2; MAPKAPK3; SUPT20H; DUSP1

    Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
    Li, W; Li, H; et al. Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway. BIOLOGY OF REPRODUCTION 83:481-487(2010).
    Deshmukh, HS; McLachlan, A; et al. Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:834-845(2009).

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