MAPK14
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Official Full Name
mitogen-activated protein kinase 14 -
Overview
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
MAPK14;mitogen-activated protein kinase 14;RK;p38;CSBP;EXIP;Mxi2;CSBP1;CSBP2;CSPB1;PRKM14;PRKM15;SAPK2A;p38ALPHA;MAP kinase 14;p38alpha Exip;p38 MAP kinase;MAP kinase Mxi2;MAP kinase p38 alpha;CSAID-binding protein;Csaids binding protein;MAX-interacting protein 2;stress-activated protein kinase 2A;p38 mitogen activated protein kinase;mitogen-activated protein kinase p38 alpha;cytokine suppressive anti-inflammatory drug binding protein;cytokine suppressive anti-inflammatory drug-binding protein
Recombinant Proteins
- Human
- Mouse
- Rat
- Insect Cells
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- Non
- GST
- MBP
- Fc
- Flag
- Avi
- DDK
- Myc
Involved Pathway
MAPK14 involved in several pathways and played different roles in them. We selected most pathways MAPK14 participated on our site, such as ADP signalling through P2Y purinoceptor 1,AGE/RAGE pathway,ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of the AP-1 family of transcription factors | ATF2,JUN |
| Adrenergic signaling in cardiomyocytes | PLCB4,CALM2A,SCN1B,MYL3,TNNC1,ATF6B,CALM2B,ADCY8,CACNB2A,ATP1A2 |
| Activated TLR4 signalling | APPB,CHUK,JUN,DUSP6,TLR6,PELI3,NOD1,IRAK3,SAA1,S100A12 |
| ADP signalling through P2Y purinoceptor 1 | GNB5 |
| AGE/RAGE pathway | TIRAP,EGFR,AGER,MMP13,CHUK,JUN,ATF2,DIAPH1,LGALS3,DDOST |
| Amyotrophic lateral sclerosis (ALS) | TNFRSF1B,GPX1,CASP12,SLC1A2,TNF,BCL2L1,TP53,Casp3,CAT,TOMM40 |
| ATF-2 transcription factor network | DDIT3,GADD45A,CDK4,RUVBL2,ATF2,HRK,CBFB,CSRP2,DUSP1,KAT5 |
Protein Function
MAPK14 has several biochemical functions, for example, ATP binding,MAP kinase activity,MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK14 itself. We selected most functions MAPK14 had, and list some proteins which have the same functions with MAPK14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | MAPK8,CYP1A2,LAMB1,YES1,DNM2,HSPA2,LUC7L2,SCNM1-PS,ARPC4,CALU |
| ATP binding | MAP4K3,KALRN,SMYHC3,PIK3C2G,TGFBR1,MAT2AA,UBE2IA,RUVBL2,GALK1,CDK8 |
| protein binding | GRN,NAPB,NCF2,PDLIM7,CAMKK1,USP12,SMCP,IMPA1,RAG1,AGRN |
| protein phosphatase binding | CSF1R,PIK3R1,MET,FLT4,FGF19,KCNN4,PPP6R1,HSF4,ANAPC4,SKAP1 |
| MAP kinase kinase activity | MAP2K1,MAP2K7,MAP2K3,MAP3K14,MAP2K2A,SBK3,MAP2K6,MAP3K20,ALPK2,MAP2K2B |
| protein serine/threonine kinase activity | STK35L,CDK11B,RAF1B,DAPK1,STK40,EIF2AK3,DCKL1B,MAP3K2,BMP2K,HUNK |
| MAP kinase activity | NLK2,NLK,MAPK13,MAPK12,MAPK14A,MAPK12A,MAPK8B,MAPK4,MAPK14B,MAPK15 |
| NFAT protein binding | PPARA,SFPI1,GATA4,FOXP3,SPI1 |
Interacting Protein
MAPK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK14.
MAPKAPK2;MAPKAPK3;SUPT20H;DUSP1
MAPK14 Related Signal Pathway
Resources
Research Area
Apoptosis Intracellular KinasesHistone Phosphorylation
Diabetic Peripheral Neuropathy
Intracellular Kinases in the Akt Pathway
p38 MAP Kinases
Negative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
Intracellular Signaling Molecules in Angiogenesis
Glomerulonephritis Therapeutic Targets
Reperfusion Injury Therapeutic Targets
Rheumatoid arthritis Therapeutic Targets
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
Related Services
Related Products
References
- Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
- Li, W; Li, H; et al. Tumor Necrosis Factor Stimulates Matrix Metalloproteinase 9 Secretion from Cultured Human Chorionic Trophoblast Cells Through TNF Receptor 1 Signaling to IKBKB-NFKB and MAPK1/3 Pathway. BIOLOGY OF REPRODUCTION 83:481-487(2010).
- Deshmukh, HS; McLachlan, A; et al. Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:834-845(2009).
