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Official Full Name mitogen-activated protein kinase 8
Background The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
Synonyms MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC; Stress-activated protein kinase JNK1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
    Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
    Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
    Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
    Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
    Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
    Human MAPK8-781H Recombinant Human MAPK8, GST tagged Insect Cell GST
    Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST
    Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
    Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7
    Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
    Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7
    Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A

    MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MEF2CA; PRKCG; PAK2; MAP2K2B; AKT3A; DUSP16; CACNA1B; FGF19; ELK1; JUND
    ErbB signaling pathway GSK3B; NRG1; PLCG2; MAPK3; AKT2L; BAD; PAK6; GSK3AA; ERBB4A; NCK2A
    Ras signaling pathway PAK1; GNB3; FOXO4; RASGRF2; PIK3CD; PLA2G10; GNG7; INS2; ANGPT1; GNG4
    cAMP signaling pathway CALM3; GLI3; CREB5; CNGA4; SUCNR1; ATP2B4; CNGA2; ATP1A4; ROCK2; NFKB1
    FoxO signaling pathway ARAF; TNFSF10; KRAS; PIK3CG; TGFBR1A; RBL2; BCL6A; CDKN2B; ATM; MAP2K2
    Sphingolipid signaling pathway TRP53; MAP2K1; PPP2R1B; SPTLC1; ACER1; PPP2R5C; CERS5; OPRD1; PPP2R2A; GNAQ
    Protein processing in endoplasmic reticulum HSC70; CALRL2; EIF2S1B; MAPK8; MAN1A; ERO1LB; SEC61G; UBQLN4; CRYAA; HSP90AA1
    Wnt signaling pathway PRKCB; WNT1; PRKACAA; FBXW2; WIF1; CCND2; PORCN; WNT9B; CAMK2G; PSEN1
    Osteoclast differentiation PLCG2; PIK3CD; AKT1; STAT2; RAC1; IL1A; MAP3K14; LILRB1; PPP3R1; CSF1R
    Focal adhesion RAC2; ITGB1; PIK3CG; LAMB1A; VEGFAA; FN1; PAK7; ITGAV; BRAF; CAV2
    Toll-like receptor signaling pathway TMED7-TICAM2; RAC1A; PIK3R1; TLR2-2; RAC1; IFNPHI3; MAPK11; TLR4; TLR9; TNF
    NOD-like receptor signaling pathway IL8L2; RELA; MAPK1; MAPK11; IL18; MAPK3; MAPK8A; CARD9; PYDC1; NFKBIB
    RIG-I-like receptor signaling pathway TRIM25; IRF3; CXCL10; IFNA17; AZI2; Ifna11; PL10; NT5C3; IFIH1; DDX58
    Fc epsilon RI signaling pathway KRAS; MAPK10; MAP2K2; NRAS; TNF; PIK3R5; IL5; PDPK1; MAPK1; MAPK3
    TNF signaling pathway PIK3CB; PIK3R3; MAP2K6; MAPK11; IL18R1; CCL5; PIK3CA; SELE; AKT1; CASP8
    Neurotrophin signaling pathway PIK3R5; BRAF; RAP1A; MATK; PLCG2; HRAS; PSEN2; CALML5; ABL1; IRAK1
    Retrograde endocannabinoid signaling GABRA2; GNG12; MAPK8; GNAI1; GNAO1; GABRA4; PLCB1; GABRB1; GNG13; GNGT1
    Dopaminergic synapse CALML3; ITPR1; KIF5B; GSK3B; SLC18A1; GNB3; PRKACB; PPP2R3A; COMT; GRIA3
    Inflammatory mediator regulation of TRP channels PPP1CC; PTGER4; CYP2J5; ASIC4; CALML3; KLK1B4; ITPR1; HTR2A; PLA2G6; MAPK10
    Insulin signaling pathway PPP1R3C; G6PCA.2; PHKA2; FLOT1; PRKAB1B; PIK3CG; FLOT1A; SOCS3; GSK3B; FBP1B
    Progesterone-mediated oocyte maturation CCNB2; CPEB2; MAD2L1; MAPK13; CPEB1A; CPEB3; MAPK8; RPS6KA2; MAD2L2; ANAPC5
    Prolactin signaling pathway STAT3; TH; INS1; SIRPA; CCND2; RAF1; LHCGR; MAPK8; KRAS; GALT
    Adipocytokine signaling pathway G6PC3; ACSL5; LEPA; G6PC; NFKBIA; PPARAB; ACSL1B; ACSBG1; NFKBIE; RXRGB
    Type II diabetes mellitus PRKCZ; PIK3CB; HK2; HK1; PRKCE; INS1; MAPK9; IRS4; MAPK1; PDX1
    Insulin resistance TRIB3; PRKAG3B; PPARGC1B; RPS6KB1; SLC27A5; CREB3L3; CREB3L3L; PIK3CG; INSRB; IKBKB
    Non-alcoholic fatty liver disease (NAFLD) IL-8; IL6; MLXIPL; IL1A; NDUFAB1; NDUFS7; NDUFA10; CDC42; LEP; NDUFB11
    Epithelial cell signaling in Helicobacter pylori infection GIT1; ATP6V0D1; CDC42; MAPK13; ATP6V1G3; ATP6V1G2; ATP6V0D2; CXCR2; F11R; LYN
    Shigellosis HCLS1; RIPK2; IL-8; DIAPH1; FBXW11; NFKB1; WASF1; UBE2D2; IKBKG; ITGA5
    Salmonella infection DYNC1I1; RELA; WASLA; ARPC5B; CXCL2; CCL4L1; CXCL1; MAPK8; RILP; CXCL3
    Pertussis IL12A; TLR4; CD14; IRF1; Itgam&Itgb2; C1RA; GM5077; AMCF-II; C1R; Casp3
    Chagas disease (American trypanosomiasis) CCL5; MYD88; IL-8; TGFBR1; CD3E; IFNB1; IL10; GNAQ; PIK3R2; TGFBR2
    Toxoplasmosis HLA-DPB1; PIK3R2; LAMA1; PIK3CA; Toxoplasma Gondii Profilin Family Protein; LAMC2; MAPK12; Toxoplasma Gondii Major Surface Antigen P30; BIRC8; LAMC1
    Tuberculosis IFNA2; SPHK2; MAPK12; CLEC7A; HSPD1; ITGB2L; CD14; IFNG; IRAK4; PPP3CB
    Hepatitis C CLDN22; HRAS; CLDN9; IFNA8; SOCS3; IFNA14; MAPK11; PIK3R3; IFNA4; IFNAR2
    HTLV-I infection CD3E; DVL1; PPP3CB; CDC23; TGFB1; CDC26; EP300; POLD2; TGFB2; RRAS2
    Herpes simplex infection OAS1; IFIT1; RELA; IRF9; BLA; SOCS3B; IFNA6; PVRL1; HLA-DPB1; IFNB
    Epstein-Barr virus infection CSNK2A2; CSNK2B; RAN; HSPA8; POLR2F; PRKACG; POLR3C; LYN; SHFM1; NFKBIE
    Pathways in cancer LAMA3; CCNE2; GSK3B; RUNX1T1; GNAI2; PLCG1; RAC2; LPAR5; TGFB3; NFKBIA
    Colorectal cancer RAC3; PIK3CG; PIK3R2; SMAD4; LEF1; FOS; RAF1; MAPK3; MAPK8; BCL2
    Pancreatic cancer BCL2L1; PIK3CA; AKT1; CASP9; RAF1; VEGFA; CDC42; TRP53; MAPK10; SMAD4
    Choline metabolism in cancer DGKD; EGF; PIP5K1B; PIK3CA; PCYT1A; DGKZ; SLC44A1; MAP2K1; PPAP2B; RHEB

    MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activity MAPK8; MAPK9; MAPK10; ALPK2
    enzyme binding CYB5A; DHCR24; DDC; PARK2; PCCA; GOLPH3; PLAUR; PDCD2; MAT2B; DAOA
    histone deacetylase binding ANKRD1; PHB; MAGEA1; TCF21; ZNF703; CCND1; YWHAE; FOXP3; KAT2A; ZFP932
    histone deacetylase regulator activity MAPK8; NCOR1; TRP53; TP53
    protein binding CHD; PRDM13; ACAA2; LAMP1; TECPR2; RPS6KA5; HADHB; PDS5A; HPX; GPR177
    protein serine/threonine kinase activity ACVR1BA; SGK2B; PKMYT1; TTBK2; MAP2K6; ULK1; MASTL; CAMKK1A; CLK4; STK3

    MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.


    Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
    Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).

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