MAPK8 Protein

MAPK8

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MAPK8

Official Full Name mitogen-activated protein kinase 8
Background The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
Synonyms MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His Inquiry
    Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A Inquiry
    Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His Inquiry
    Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST Inquiry
    Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His Inquiry
    Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A Inquiry
    Human MAPK8-781H Recombinant Human MAPK8, GST tagged Insect Cell GST Inquiry
    Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST Inquiry
    Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST Inquiry
    Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A Inquiry
    Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A Inquiry
    Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A Inquiry
    Human MAPK8-2242H Recombinant Human MAPK8 protein, His-tagged Insect Cell His Inquiry
    Human MAPK8-2420H Recombinant Human MAPK8 Protein, His-tagged E.coli N-His Inquiry
    Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Involved Pathway Protein Function Interacting Protein MAPK8 Related Articles

    MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK1; MAP3K2; MAPK8B; TRAF6; CACNA1SA; CACNB4; SOS1; PPM1NB; PPP3CCA; CACNA2D4
    ErbB signaling pathway MAP2K4; PIK3R3; GRB2A; ERBB2; NCK1; NRAS; MTOR; AKT2; PIK3R1; CBLB
    Ras signaling pathway PDGFRB; GNB1; MAPK8; CALM1; PAK3; MAPK3; ELK1; RASA4; CALM3; RRAS2
    cAMP signaling pathway GIPR; HTR1E; CREB5; GRIN2A; PIK3CD; PTCH1; CREB3L3; VIPR2; CALM1; MAPK3
    FoxO signaling pathway MAPK9; PIK3CG; S1PR4; CDKN2D; PRKAB1A; PIK3CB; SMAD4; GADD45G; ARAF; PTENA
    Sphingolipid signaling pathway SGPP1; PLCB1; MAP2K1; PPP2R5B; RHOA; CERS2; PIK3R2; PLCB3; RAF1; TP53
    Protein processing in endoplasmic reticulum UBQLN4; HSPA1B; DNAJC3; SEC24C; ATF4; PDIP5; HSPA1A; HSPH1; STT3A; BCL2
    Wnt signaling pathway PORCN; PRKCBB; FZD3A; SFRP4; WNT7B; PORCNL; DKK1; NFATC1; PRKCG; DKK2
    Osteoclast differentiation FYN; TAB2; NFKBIA; LCK; STAT2; LILRA2; NCF2; TYK2; SQSTM1; TREM2
    Focal adhesion RAC3; ILK; FYN; IGF1RA; SHC1; VEGFC; ACTN2; PTENA; IGF1; MYL10
    Toll-like receptor signaling pathway SPP1; TLR1LB; MAPK9; MAPK8A; TLR5B; PIK3CG; RIPK1; PIK3CA; IFNA12; STAT1B
    NOD-like receptor signaling pathway NFKBIB; NLRC4; MAPK3; NFKBIA; CASP1; IL18; HSP90AB1; CXCL8B.3; HSP90B1; MAPK8
    RIG-I-like receptor signaling pathway TANK; MAPK8B; IFNB; NLRX1; DHX58; NFKBIB; IFNA14; IFNK; TRIM25; MAVS
    Fc epsilon RI signaling pathway RAC2; LAT; MS4A2; PIK3CD; IL3; PLA2G4C; PIK3R3; INPP5D; PRKCA; MAPK8
    TNF signaling pathway NFKBIA; TNF; PIK3R2; Casp3; MMP9; CREB5; CASP8; MAP2K7; BAG4; TRAF3
    Neurotrophin signaling pathway NTRK3; PSEN1; SOS1; NFKBIA; AKT2; PTPN11; GAB1; KRAS; MAPK3; NFKBIB
    Retrograde endocannabinoid signaling PLCB2; GABRP; GNGT1; GABRA3; GNAI3; MAPK8; GNG7; ABHD6; MAPK3; GABRG3
    Dopaminergic synapse PLCB1; GRIA2; TH; AKT1; PPP1CC; GNG5; GNG4; GNB4; DRD5; SCN1A
    Inflammatory mediator regulation of TRP channels HTR2A; CALM1; TRPV1; CALML3; PIK3R5; PPP1CA; CAMK2B; PPP1CB; PRKCH; CYP2C70
    Insulin signaling pathway LIPE; PRKAR1AB; PCK1; PPP1R3B; PRKAB1; PIK3CG; RPS6KB1; CALM2B; PPP1R3CA; CALM1A
    GnRH signaling pathway RAF1A; ITPR3; CGNRH-R; ADCY1A; MAPK8; PLD1A; MAPK12; GRB2A; MMP14A; CDC42L2
    Progesterone-mediated oocyte maturation HSP90AB1; CCNA1; AKT2L; BRAF; RPS6KA2; PIK3R5; CDK1; CPEB1; PIK3R3A; CDC25A
    Prolactin signaling pathway PIK3R2; ELF5; SHC2; PIK3CG; FOS; GSK3B; SOCS3; RAF1; CSN2; SOS1
    Adipocytokine signaling pathway AKT2L; PRKAA1; TRADD; CPT1B; CAMKK2; ADIPOR2; PRKAA2; CAMKK1; PCK1; PRKAG1
    Type II diabetes mellitus IRS1; SLC2A2; PIK3R2; PKM2; HK1; HK3; INS2; PIK3CD; SOCS1; MTOR
    Insulin resistance INSR; PRKAG1; PRKAB2; PTPN11; RPS6KA6; PIK3CG; MAPK8A; NR1H3; PYGB; AKT1
    Non-alcoholic fatty liver disease (NAFLD) Casp3; ITCH; TNFRSF1A; NDUFS6; NDUFB7; SREBF1; COX8C; COX7B; RAC1; AKT1
    Epithelial cell signaling in Helicobacter pylori infection ATP6V0D1; IKBKG; ATP6V0E1; MAP3K14; ATP6V1C2; MAPK11; CCL5; ATP6AP1; IKBKB; ATP6V1F
    Shigellosis HCLS1; MAPK3; ACTG1; MAPK10; MAPK12; NFKB1; MAPK13; IKBKG; SRC; U2AF1
    Salmonella infection PLEKHM2; ARPC4L; TLR4BB; NFKB1; CCL3L1; NOS2A; CDC42; WASB; MAPK11; CCL4
    Pertussis CFL2; CXCL5; IL12B; C1RA; IRF8; GNAI1; IRF3; CALML3; RELA; CALM1
    Chagas disease (American trypanosomiasis) CCL3L1; TGFBR2; MAPK12; SERPINE1; CCL2; MAPK11; TLR2; MAPK3; AKT1; TGFB3
    Toxoplasmosis MAPK1; HSPA2; CYCS; IFNG; BIRC7; PIK3R1; BCL2L1; Toxoplasma Gondii Microneme Protein MIC3; IRAK4; TGFB1
    Tuberculosis TGFB3; PPP3CB; ATP6V0D2; Ifna15; TLR2; RFX5; HLA-DPA1; IL12B; CAMK2A; IFNA7
    Hepatitis C CLDN7; DDX58; PPP2R1B; TLR3; MAPK9; CXCL8; IFNA6; IFNA7; IFNA2; RAF1
    Hepatitis B HRAS; BIRC5; MAPK10; NFATC3; RELA; MAPK1; Ifna11; TGFB2; DDB2; IFNA10
    Influenza A HLA-DQB1; XPO1; PIK3R1; MAPK9; TNFRSF1A; IVNS1ABP; STAT2; Ccl12; RNASEL; RELA
    HTLV-I infection SFPI1; PRKACA; NRP1; FZD5; PDGFRB; POLD1; HLA-DQA1; DVL1; HLA-G; IL2RA
    Herpes simplex infection TBK1; TAF6L; IFN-a; HNRPK; CLOCKA; PPP1CAA; EIF2AK1; IFNAR2; HLA-F; GTF2IRD1
    Epstein-Barr virus infection GTF2B; PRKACA; MAP3K7; MAPK10; HSPB2; HLA-DPB1; MAP3K14; POLR1D; LYN; POLR3C
    Pathways in cancer WNT5A; FZD10; PLCG2; PTGER1; HDAC2; PRKCB; CDH1; TRAF5; RASGRP3; FIGF
    Colorectal cancer MAPK3; ARAF; PIK3CG; CCND1; TGFB2; TGFBR1; FOS; PIK3CA; BRAF; APC
    Pancreatic cancer PIK3CA; ARAF; TGFA; PIK3R2; TP53; AKT1; RALGDS; TGFB1; RAC3; STAT1
    Choline metabolism in cancer PIK3R5; CHKA; Pdgfa&Pdgfb; AKT2; MAPK8; PCYT1A; RAC3; TSC2; PLD1; SLC22A5

    MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding STRADB; ABCB8; STK25A; EPHA4A; DNAH6; SMARCA4; PRKCH; SUCLG1; EIF2AK3; GSK3B
    JUN kinase activity MAPK9; MAPK10; MAPK8; ALPK2
    enzyme binding PLSCR4; DAOA; PDCD2; NLRP1; UGT1A6B; CYP3A4; RPS2; IQCB1; LAMB1; EIF4E
    histone deacetylase binding TOP2B; BCOR; HIF1A; SP2; MEF2B; NACC2; CEBPB; CDC20; RELA; MAGEA1
    histone deacetylase regulator activity MAPK8; TP53; NCOR1; TRP53
    protein binding CDKN2C; CDC42; TTK; KCNA2; PHF15; NLRP12; MGRN1; SERPINA5; PTH2R; MB21D2
    protein serine/threonine kinase activity GAK; RAF1; WNK2; BMPR1AB; MAPK6; DCLK3; PRKD1; CAMK2B1; DYRK1B; CASK

    MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.

    JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7

    Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
    Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).

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