• Official Full Name

    mitogen-activated protein kinase 8

  • Background

    The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
  • Synonyms

    MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC; Stress-activated protein kinase JNK1;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|MBP
    • His|T7
    • Myc
    • DDK
    • N/A
    • N
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST
    Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
    Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
    Human MAPK8-781H Recombinant Human MAPK8, GST tagged Insect Cell GST
    Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
    Human MAPK8-2242H Recombinant Human MAPK8 protein, His-tagged Insect Cell His
    Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
    Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
    Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK8-2420H Recombinant Human MAPK8 Protein, His-tagged E.coli N-His
    Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
    Human MAPK8-1137H Recombinant Human MAPK8 Protein (S2-E364), His tagged E.coli His
    Human MAPK8-3435H Recombinant Human MAPK8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human MAPK8-1136H Recombinant Human MAPK8 Protein (S2-E364), Tag Free E.coli No tag
    Human MAPK8-3435H-B Recombinant Human MAPK8 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7
    Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
    Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
    Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A
    Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAPK8 Related Articles
    • MAPK8 Related Research Area
    • MAPK8 Related Signal Pathway

    MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathwayPIK3CA;NRAS;MAP2K2;BRAF;PIK3CD;RAF1B;SRC;MAPK8;SHC1
    Ras signaling pathwayFGF13;TEK;CSF1;VEGFA;PRKACA;RELA;RAC1;PRKACB;ARF6
    cAMP signaling pathwayGNAS;NPY;CREB3L3;CNGA1;GPR119;HTR6;GRIA4;FFAR2;CAMK2B
    FoxO signaling pathwayBCL6;FOXO6;SMAD4;PLK3;PIK3R1;CCNG2;FOXO1B;FOXO3;MAPK1
    Sphingolipid signaling pathwayNOS3;ROCK2;PLD2;PIK3R1;PPP2R2A;SPTLC1;SMPD1;MAPK11;TRADD
    Protein processing in endoplasmic reticulumUBE2G2;UBE4B;CAPN1B;SAR1B;HYOU1;DNAJC5;PDIP5;PKZ;LMAN1L
    Wnt signaling pathwayDVL3A;FRAT2;RHOA;FBXW11;CSNK1A1L;NFATC2;BTRC;CCND1;NFATC4
    Osteoclast differentiationCAMK4;LILRB1;TRAF2;SOCS1;IFNAR2;TNFRSF1A;cgr2b;SIRPG;PPP3R2
    Toll-like receptor signaling pathwayLBP;TLR8;IFNA6;TICAM2;CASP8;TRAF6;MAP3K7;CD40;CXCL10
    NOD-like receptor signaling pathwayMAPK12B;TRAF6;NLRP3;TNFAIP3;RELA;MAP3K7IP3;HSP90AA1.2;TAB3;HSP90AB1
    RIG-I-like receptor signaling pathwayCASP10;MAPK11;MAPK12A;MAPK8B;NFKB1;MAPK10;TBK1;IFNA5;IFNA2
    Fc epsilon RI signaling pathwayAKT2;PLCG2;FYN;MAP2K3;LAT;KRAS;MAPK12;PIK3R5;SYK
    TNF signaling pathwayBAG4;Casp3;BIRC3;CXCL5;CXCL1;CCL5;TNFAIP3;PIK3R1;VCAM1
    Neurotrophin signaling pathwayNTRK1;RHOA;CAMK2A;NGFRAP1;SORT1;RPS6KA2;PTPN11;NFKBIE;SH2B1
    Retrograde endocannabinoid signalingGRM1;GNG8;GNB1;GABRP;GNG4;GNG11;MAPK10;GABRD;GABRG1
    Dopaminergic synapsePPP2R3A;CREB3;PPP2R5D;AKT2;DRD1A;CREB3L2;AKT1;GNAQ;GRIA1
    Inflammatory mediator regulation of TRP channelsMAP2K6;CALM3;PLCB3;HRH1;PLA2G4A;CALML5;PPP1CC;PRKACA;HTR2C
    Insulin signaling pathwayHK1;PYGB;PKLR;ACACB;PRKAB1;PPP1R3A;FOXO1;MAPK3;CALM1B
    Progesterone-mediated oocyte maturationRAF1B;INSB;ADCY1A;INS;CDC25B;CCNA1;CCNB2;CPEB1A;PIK3R3B
    Prolactin signaling pathwaySRC;GALT;KRAS;STAT5B;SOCS2;MAPK10;PIK3R2;STAT3;NFKB1
    Adipocytokine signaling pathwayTNFRSF1A;NFKBIAA;LEPA;MAPK8B;PTPN11B;RXRGA;PRKAG2;G6PCA.1;LEPB
    Type II diabetes mellitusIRS1;SOCS1;MAFA;IRS2;MAPK8;PRKCZ;INS-IGF2;SLC2A4;TNF
    Non-alcoholic fatty liver disease (NAFLD)ERN1;COX7A2;SDHA;NDUFA4L2;RXRA;NDUFA5;DDIT3;PRKAA2;AKT1
    Epithelial cell signaling in Helicobacter pylori infectionATP6V0A4;RAC1;TJP1;IKBKB;CDC42;ATP6V1G1;MAP3K14;ATP6AP1;CXCL1
    Salmonella infectionRAC1A;IL6;TLR4;WASLA;IFNGR1;WASF1;CASP1;PFN4;KLC2
    Chagas disease (American trypanosomiasis)GNA11;TLR6;PLCB2;IRAK4;CCL3L1;PLCB4;FASLG;Ccl12;IL6
    ToxoplasmosisToxoplasma Gondii Dense Granule Protein 7;Toxoplasma Gondii Major Surface Antigen P30;HSPA8;STAT3;LAMB2;GNAI3;IFNGR2;MAP2K6;LAMA3
    Herpes simplex infectionSRSF2;SRPK1;PTPN11B;TRP53;Ifna11;CLOCK;OAS2;CSNK2A2A;PPP1CBL
    Epstein-Barr virus infectionTAB2;RIPK1;MAPK11;CCNA1;PSMD4;CD38;HSPA6;MAP2K4;POLR2J
    Pathways in cancerWNT8B;TRAF1;Kitl;CBL;HDAC2;PIK3R1;HGF;ABL1;FGF2
    Colorectal cancerBRAF;SMAD3;MSH3;BCL2;AXIN1;MAPK9;PIK3R2;TGFB2;MLH1
    Pancreatic cancerAKT2;TGFBR1;MAP2K1;TRP53;BRAF;TP53;BCL2L1;PIK3R3;MAPK3
    Choline metabolism in cancerTAE1;PDGFD;FOS;DGKZ;WASL;SLC22A5;WASF1;MAPK10;SLC22A3

    MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activityALPK2;MAPK9;MAPK8;MAPK10
    histone deacetylase bindingNR2C1;MAPK8;CEBPA;HOXA10;FOXP3;HDAC5;SIRT2;PHB;DHX36
    histone deacetylase regulator activityMAPK8;TP53;NCOR1;TRP53
    protein bindingEIF4B;INHBA;ESYT2;EIF4E;CLDN16;TFIP11;CALML3;CDK10;PKN2
    protein serine/threonine kinase activityRAF1A;IRAK4;SNRKA;PAK6;ACVR1B;PIK3CA;LMTK3;PRKACAB;TESK1

    MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.


    Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
    Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).
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