MAPK8 Protein


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Official Full Name mitogen-activated protein kinase 8
Background The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
Synonyms MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC; Stress-activated protein kinase JNK1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
    Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
    Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
    Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
    Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
    Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
    Human MAPK8-781H Recombinant Human MAPK8, GST tagged Insect Cell GST
    Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST
    Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
    Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7
    Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
    Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7
    Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A
    Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-2242H Recombinant Human MAPK8 protein, His-tagged Insect Cell His
    Human MAPK8-2420H Recombinant Human MAPK8 Protein, His-tagged E.coli N-His
    Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PRKACB; HSPA1B; TGFB1A; FGF6; SRFA; MAPK4; RAP1A; FGF6A; MAPK9; FGF18
    ErbB signaling pathway NRAS; MTOR; BRAF; ABL2; PTK2AA; CAMK2G1; MAPK9; PIK3R5; ABL1; MAP2K1
    Ras signaling pathway ETS1; PRKCG; PDGFD; RASAL3; PLA2G4A; GNG7; RASSF1; PLA2G12B; FGF6; FGF21
    cAMP signaling pathway RAP1A; PTCH1; NFATC1; TNNI3; RAC2; PPP1CA; GRIA1; F2R; PLN; NFKB1
    FoxO signaling pathway PIK3R3B; SMAD4; PRKAB1B; FOXO3A; MAPK12; KLF2B; PRKAB1; FOXO1; GADD45B; FOXO6
    Sphingolipid signaling pathway PPP2R5C; GNAQ; GNAI1; LOC100328615; SPHK1; MAPK8; NFKB1; PRKCA; PRKCB; SMPD1
    Protein processing in endoplasmic reticulum DNAJC5; DNAJC5GB; HSPA1L; DNAJC3; RAD23B; DNAJC5AA; BCL2A; UBE2D3; HSPBP1; CRYAA
    Wnt signaling pathway WIF1; PRKACBB; MAP3K7; LRP6; FOSL1A; MMP7; DKK1B; CCND2; BAMBI; WNT1
    Osteoclast differentiation PPP3CA; IFNAR1; CYBA; PPP3CB; FCGR4; LILRA3; MAPK12; TNFRSF11A; NCF1; IFNAR2
    Toll-like receptor signaling pathway CXCL11; IL6; RAC1B; MAP2K2A; CXCL9; IKBKB; TLR2; IFNA4; CD40; MAPK14B
    NOD-like receptor signaling pathway NLRC4; MAPK12B; RIPK2; IL-8; NAIP6; CXCL8B.3; NLRP3; CCL2; PSTPIP1; CASP5
    RIG-I-like receptor signaling pathway IFNA21; NLRX1; TBKBP1; DDX3X; MAPK14A; TRAF6; TNF; ATG12; RIPK1; IL8L1
    Fc epsilon RI signaling pathway VAV3; SYK; PLA2G4A; MAPK10; VAV1; MAPK1; PLA2G4F; MAP2K3; RAC2; MAPK3
    TNF signaling pathway MAPK12; CREB3L1; PGAM5; PIK3R1; BAG4; Ccl12; CCL2; IL18R1; PTGS2; MMP14
    Neurotrophin signaling pathway PSEN2; MAP2K7; MAPK13; RAP1B; CALM1; RAPGEF1; MATK; TP53; CALM2; BAX
    Retrograde endocannabinoid signaling PTGS2; Adcy4; GNG4; GNAO1; MAPK3; FAAH; RIMS1; GNG13; GNB2; GNAQ
    Dopaminergic synapse GNG8; PPP2R2D; PPP2R5D; PRKACA; GNG3; CREB3L2; GRIA1; GNAI2; MAPK13; PPP3CA
    Inflammatory mediator regulation of TRP channels CALM2; PRKCH; CYP4A12A; TRPV3; KLK1B4; CYP2J2; PRKCE; PIK3CG; MAPK9; PTGER4
    Insulin signaling pathway CALM4; ELK1; MAP2K2B; MAPK10; FLOT1B; FBP1; PRKAG3; PPP1R3DA; PPP1R3CA; AKT3A
    GnRH signaling pathway MAPK8B; MAPK7; ATF4B1; ADCY1A; CALM2B; CALM2A; GNA11A; MAP3K3; GNAS; CDC42L2
    Progesterone-mediated oocyte maturation PIK3CA; MAPK3; PIK3R2; CPEB1; CPEB2; PRKACG; CDC25B; MAPK1; ANAPC1; BUB1
    Prolactin signaling pathway RELA; LHCGR; MAP2K2; PPIB; NFKB1; PRL; MAPK12; STAT5A; ELF5; SOCS4
    Adipocytokine signaling pathway LEP; ACSL4A; ADIPOR2; ADIPOQ; TRAF2; TNF; CAMKK1A; ACSL1A; NFKB1; G6PCA.2
    Type II diabetes mellitus SLC2A4; MAFA; ADIPOQ; PIK3R1; HK1; HK3; IRS1; MTOR; TNF; PIK3CD
    Insulin resistance G6PC2; PPP1CAA; G6PC3; MTOR; SLC2A1; ACACB; SOCS3; PRKCZ; PTPN11; SLC27A4
    Non-alcoholic fatty liver disease (NAFLD) NR1H3; COX8C; MAPK8; NDUFA11; XBP1; UQCR11; NDUFB4; MAPK10; PRKAA2; RELA
    Epithelial cell signaling in Helicobacter pylori infection PLCG1; LYN; MAPK13; ATP6V1G2; CDC42; MAPK11; PTPN11; ATP6V0C; MAPK10; JAM2
    Shigellosis PFN2; PFN1; VCL; MAPK12; NFKB1; U2AF1; PFN3; MAPK9; CDC42; ELMO1
    Salmonella infection PFN4; TLR4BA; MAPK12B; ACTB1; IFNG; DYNC2H1; WASLB; ROCK2B; FLNB; MAPK14B
    Pertussis IRF3; MAPK11; MAPK1; MAPK3; CALM2; C2; C1R; IRAK1; C4BPB; ITGB2L
    Chagas disease (American trypanosomiasis) TNFRSF1A; GNA11; SERPINE1; PPP2R1A; TGFB2; PLCB1; CD3D; IL-8; MAPK12; GNAL
    Toxoplasmosis PIK3R3; MAPK10; STAT3; LAMA5; LAMB1; IRAK1; BCL2L1; TGFB1; Toxoplasma Gondii Dense Granule Protein 7; LAMC2
    Tuberculosis HLA-DQB1; PPP3R1; CLEC7A; FCGR1; CASP8; IL23; PIK3C3; CD14; RFX5; FCGR4
    Hepatitis C IFNA13; CLDN17; EIF2AK2; PIK3CG; Ifna11; IFNA5; MAPK3; EIF2AK1; IFNB1; IFIT1
    Hepatitis B EP300; TICAM2; YWHAZ; NFKB1; Fasl; PRKCB; HRAS; FASLG; IL6; MAPK3
    Influenza A IRF3; CCL5; IL1A; IFNA21; MX1; TNFSF10; NXT2; RELA; HSPA1L; IL12A
    HTLV-I infection CDC27; PPP3CA; HLA-B; VDAC2; VCAM1; RELB; VDAC1; IKBKB; Pdgfa&Pdgfb; NRP1
    Herpes simplex infection SRSF1B; HLA-DQB1; CYCS; IKBKB; TNFRSF1A; TRAF6; IFNGR1; SOCS3B; SRPK1B; SFRS3B
    Epstein-Barr virus infection PSMD7; SKP2; PSMD11; PSMD2; POLR3F; MAPK10; TRAF3; PSMD13; EIF2AK4; POLR1D
    Pathways in cancer LAMB2; APC; GNB2; BIRC3; TRAF1; MDM2; PML; VEGFB; MSH3; SUFU
    Colorectal cancer AKT2; SMAD3; LEF1; APPL1; PIK3CD; PIK3R1; MAPK3; TGFBR2; RAF1; FOS
    Pancreatic cancer BCL2L1; STAT1; SMAD4; PLD1; MAPK1; VEGFA; TGFB2; AKT2; MAPK10; BAD
    Choline metabolism in cancer CHKB; MAPK9; PIK3R5; MAPK3; RPS6KB2; WASL; SP1; RAC3; SLC22A1; KRAS

    MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ABCA3; PSMC3; NAV3; ROR2; ATP7B; IGHMBP2; BAT1; Abcb1b; AKT1; RBKS
    JUN kinase activity MAPK8; MAPK10; ALPK2; MAPK9
    enzyme binding EIF4E; HIST1H2AK; UGT1A3; MAPK14; PIAS3; RAD9A; NCOA1; NLRP1; PARP4; PEX7
    histone deacetylase binding PKN1; NCOR2; CRY1; CDC20; PRDM1; TOP2B; SIX3; YWHAB; ZMYND15; MEF2D
    histone deacetylase regulator activity NCOR1; TP53; TRP53; MAPK8
    protein binding LDHB; LTBP1; STX4A; SUV39H1; PRPF4B; KRTAP4-12; PPP3CB; EFS; HIST2H3C2; ARFRP1
    protein serine/threonine kinase activity CSNK1G2B; VRK3; PRKY; NIM1K; PKN1; OBSCN; LRRK1; PRKCB; MAP2K7; MKNK2

    MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.


    Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
    Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).

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