MAPK8
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Official Full Name
mitogen-activated protein kinase 8
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Background
The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain. -
Synonyms
MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK8 Related Articles
- MAPK8 Related Research Area
- MAPK8 Related Signal Pathway
MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | HSC70;PRKCA;PPP3CB;MAP4K1;PLA2G4C;MAX;CACNG1;MAP2K4A;MAPK14B |
| ErbB signaling pathway | PIK3CA;NRAS;MAP2K2;BRAF;PIK3CD;RAF1B;SRC;MAPK8;SHC1 |
| Ras signaling pathway | FGF13;TEK;CSF1;VEGFA;PRKACA;RELA;RAC1;PRKACB;ARF6 |
| cAMP signaling pathway | GNAS;NPY;CREB3L3;CNGA1;GPR119;HTR6;GRIA4;FFAR2;CAMK2B |
| FoxO signaling pathway | BCL6;FOXO6;SMAD4;PLK3;PIK3R1;CCNG2;FOXO1B;FOXO3;MAPK1 |
| Sphingolipid signaling pathway | NOS3;ROCK2;PLD2;PIK3R1;PPP2R2A;SPTLC1;SMPD1;MAPK11;TRADD |
| Protein processing in endoplasmic reticulum | UBE2G2;UBE4B;CAPN1B;SAR1B;HYOU1;DNAJC5;PDIP5;PKZ;LMAN1L |
| Wnt signaling pathway | DVL3A;FRAT2;RHOA;FBXW11;CSNK1A1L;NFATC2;BTRC;CCND1;NFATC4 |
| Osteoclast differentiation | CAMK4;LILRB1;TRAF2;SOCS1;IFNAR2;TNFRSF1A;cgr2b;SIRPG;PPP3R2 |
| Focal adhesion | BCL2;COL1A1B;LAMA3;SEPP1;MYLPFB;PIP5K1C;BIRC2;PRKCBA;PTENB |
| Toll-like receptor signaling pathway | LBP;TLR8;IFNA6;TICAM2;CASP8;TRAF6;MAP3K7;CD40;CXCL10 |
| NOD-like receptor signaling pathway | MAPK12B;TRAF6;NLRP3;TNFAIP3;RELA;MAP3K7IP3;HSP90AA1.2;TAB3;HSP90AB1 |
| RIG-I-like receptor signaling pathway | CASP10;MAPK11;MAPK12A;MAPK8B;NFKB1;MAPK10;TBK1;IFNA5;IFNA2 |
| Fc epsilon RI signaling pathway | AKT2;PLCG2;FYN;MAP2K3;LAT;KRAS;MAPK12;PIK3R5;SYK |
| TNF signaling pathway | BAG4;Casp3;BIRC3;CXCL5;CXCL1;CCL5;TNFAIP3;PIK3R1;VCAM1 |
| Neurotrophin signaling pathway | NTRK1;RHOA;CAMK2A;NGFRAP1;SORT1;RPS6KA2;PTPN11;NFKBIE;SH2B1 |
| Retrograde endocannabinoid signaling | GRM1;GNG8;GNB1;GABRP;GNG4;GNG11;MAPK10;GABRD;GABRG1 |
| Dopaminergic synapse | PPP2R3A;CREB3;PPP2R5D;AKT2;DRD1A;CREB3L2;AKT1;GNAQ;GRIA1 |
| Inflammatory mediator regulation of TRP channels | MAP2K6;CALM3;PLCB3;HRH1;PLA2G4A;CALML5;PPP1CC;PRKACA;HTR2C |
| Insulin signaling pathway | HK1;PYGB;PKLR;ACACB;PRKAB1;PPP1R3A;FOXO1;MAPK3;CALM1B |
| GnRH signaling pathway | CAMK2B1;GNA11A;CAMK2G;PLCB2;CAMK2D2;CALM1B;HBEGFA;MMP2;CALM1 |
| Progesterone-mediated oocyte maturation | RAF1B;INSB;ADCY1A;INS;CDC25B;CCNA1;CCNB2;CPEB1A;PIK3R3B |
| Prolactin signaling pathway | SRC;GALT;KRAS;STAT5B;SOCS2;MAPK10;PIK3R2;STAT3;NFKB1 |
| Adipocytokine signaling pathway | TNFRSF1A;NFKBIAA;LEPA;MAPK8B;PTPN11B;RXRGA;PRKAG2;G6PCA.1;LEPB |
| Type II diabetes mellitus | IRS1;SOCS1;MAFA;IRS2;MAPK8;PRKCZ;INS-IGF2;SLC2A4;TNF |
| Insulin resistance | PPARGC1B;INSR;PIK3R3;PRKAG3B;PPP1R3A;TRIB3;PRKCZ;PPP1CBL;MTOR |
| Non-alcoholic fatty liver disease (NAFLD) | ERN1;COX7A2;SDHA;NDUFA4L2;RXRA;NDUFA5;DDIT3;PRKAA2;AKT1 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0A4;RAC1;TJP1;IKBKB;CDC42;ATP6V1G1;MAP3K14;ATP6AP1;CXCL1 |
| Shigellosis | ITGB1;ITGA5;ATG5;CD44;DIAPH1;PFN4;IKBKB;WAS;IL-8 |
| Salmonella infection | RAC1A;IL6;TLR4;WASLA;IFNGR1;WASF1;CASP1;PFN4;KLC2 |
| Pertussis | CALML5;C4BPB;IL12A;MYD88;CD14;NFKB1;CXCL5;TRAF6;MAPK13 |
| Chagas disease (American trypanosomiasis) | GNA11;TLR6;PLCB2;IRAK4;CCL3L1;PLCB4;FASLG;Ccl12;IL6 |
| Toxoplasmosis | Toxoplasma Gondii Dense Granule Protein 7;Toxoplasma Gondii Major Surface Antigen P30;HSPA8;STAT3;LAMB2;GNAI3;IFNGR2;MAP2K6;LAMA3 |
| Tuberculosis | IL10RB;HLA-DRB5;SPHK1;PPP3CC;Cd209g;PLK3;IL12B;IFNA16;NOS2 |
| Hepatitis C | MAPK8;PIAS1;MAVS;PIK3CD;NRAS;IKBKG;EIF2AK2;LDLR;MAPK1 |
| Hepatitis B | STAT5A;NFKB1;IFNA16;BCL2;RELA;IFNA7;Ifna15;PIK3CB;CREB3L2 |
| Influenza A | DDX58;NXT2;CXCL8;IFNA21;SLC25A6;IKBKE;IFN-a;TMPRSS13;BMA2 |
| HTLV-I infection | ATM;APC2;WNT9B;SMAD2;MAP2K4;HLA-B;AKT2;TGFBR1;Il2 |
| Herpes simplex infection | SRSF2;SRPK1;PTPN11B;TRP53;Ifna11;CLOCK;OAS2;CSNK2A2A;PPP1CBL |
| Epstein-Barr virus infection | TAB2;RIPK1;MAPK11;CCNA1;PSMD4;CD38;HSPA6;MAP2K4;POLR2J |
| Pathways in cancer | WNT8B;TRAF1;Kitl;CBL;HDAC2;PIK3R1;HGF;ABL1;FGF2 |
| Colorectal cancer | BRAF;SMAD3;MSH3;BCL2;AXIN1;MAPK9;PIK3R2;TGFB2;MLH1 |
| Pancreatic cancer | AKT2;TGFBR1;MAP2K1;TRP53;BRAF;TP53;BCL2L1;PIK3R3;MAPK3 |
| Choline metabolism in cancer | TAE1;PDGFD;FOS;DGKZ;WASL;SLC22A5;WASF1;MAPK10;SLC22A3 |
MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TGFBR1B;IKBKAP;SCYL2;MKNK2B;TPX2;ATAD5B;TTLL4;PIP5K1B;BCS1L |
| JUN kinase activity | ALPK2;MAPK9;MAPK8;MAPK10 |
| enzyme binding | TBP;DDC;ZNHIT6;SCNM1;HAND1;PRKDC;GBP1;CBS;TSPYL1 |
| histone deacetylase binding | NR2C1;MAPK8;CEBPA;HOXA10;FOXP3;HDAC5;SIRT2;PHB;DHX36 |
| histone deacetylase regulator activity | MAPK8;TP53;NCOR1;TRP53 |
| protein binding | EIF4B;INHBA;ESYT2;EIF4E;CLDN16;TFIP11;CALML3;CDK10;PKN2 |
| protein serine/threonine kinase activity | RAF1A;IRAK4;SNRKA;PAK6;ACVR1B;PIK3CA;LMTK3;PRKACAB;TESK1 |
MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.
JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7
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