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  • Official Full Name

    mitogen-activated protein kinase 8

  • Overview

    The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
  • Synonyms

    MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC; Stress-activated protein kinase JNK1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK8-83HFL Unactive Recombinant Full Length Human MAPK8 Protein, N-His-tagged Sf21 His Full Length
Human MAPK8-82HFL Active Recombinant Full Length Human MAPK8 Protein, N-His-tagged Sf21 His Full Length
Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST True
Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
Human MAPK8-781H Recombinant Human MAPK8 protein(Met1-Arg427), GST-tagged Insect Cells N-GST Met1-Arg427
Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP 1-72 aa
Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK8-1137H Recombinant Human MAPK8 Protein (S2-E364), His tagged E.coli His S2-E364
Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK8-3435H Recombinant Human MAPK8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAPK8-2242H Recombinant Human MAPK8 protein, His-tagged Insect Cell His 4-422aa
Human MAPK8-1136H Recombinant Human MAPK8 Protein (S2-E364), Tag Free E.coli No tag S2-E364
Human MAPK8-2420H Recombinant Human MAPK8 Protein, His-tagged E.coli N-His Tyr26-Ile321
Human MAPK8-3435H-B Recombinant Human MAPK8 Protein Pre-coupled Magnetic Beads HEK293
Human MAPK8-3168H Recombinant Human MAPK8 Protein (Tyr26-Ile321), His tagged E.coli His Tyr26-Ile321
Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7 Gly138~Val382 (Accession # Q91Y86)
Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A
Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7 Gly138~Gly370 (Accession # P49185)
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK8 Related Articles
  • MAPK8 Related Research Area
  • MAPK8 Related Signal Pathway

What is mapk8 protein?

MAPK8 protein, also known as c-Jun N-terminal kinase 1 (JNK1), is a member of the mitogen-activated protein kinase (MAPK) family. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, apoptosis, and immune response.

MAPK8 protein has been implicated in several biological processes and diseases. It has been associated with inflammation, cancer development and progression, neuronal cell survival, and response to stress and environmental stimuli. Dysregulation of MAPK8 signaling has also been linked to neurodegenerative diseases, inflammatory bowel disease, and cardiovascular disorders.

What is the function of mapk8 protein?

In biomedical research, understanding the function and regulation of MAPK8 protein is crucial for developing therapeutic interventions for various diseases. The development of specific inhibitors or activators that target the MAPK8 pathway holds promise for treating conditions such as cancer, inflammation, and neurodegenerative disorders.

Mapk8 related signaling pathway

The MAPK8 protein is involved in a signaling pathway known as the JNK signaling pathway. Upon activation, MAPK8 phosphorylates downstream target proteins, including transcription factors such as c-Jun, ATF2, and Elk-1, leading to gene expression changes and modulation of cellular responses.

Mapk8 Related Diseases

  •  Cancer: MAPK8 plays a role in tumor development and progression. Abnormal activation of MAPK8 signaling has been found in various cancers, including breast, lung, colon, and pancreatic cancer. Inhibition of MAPK8 signaling is being explored as a potential therapeutic target for cancer treatment.
  •  Neurodegenerative diseases: Activation of MAPK8 has been observed in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The dysregulation of MAPK8 signaling contributes to neuronal cell death and neuroinflammation in these diseases.
  •  Cancer therapy: MAPK8 plays a role in regulating cell proliferation, survival, and apoptosis, making it a potential target for cancer therapy. Inhibition of MAPK8 activity has been explored as a strategy to suppress tumor growth and induce apoptosis in cancer cells.

Biomedical Application of mapk8 Protein

  •  Cancer therapy: MAPK8 plays a role in regulating cell proliferation, survival, and apoptosis, making it a potential target for cancer therapy. Inhibition of MAPK8 activity has been explored as a strategy to suppress tumor growth and induce apoptosis in cancer cells.
  •  Neuroprotection: MAPK8 is involved in neuronal cell survival and death pathways. Activation of MAPK8 has been shown to protect neurons from various insults, such as oxidative stress and excitotoxicity. Therefore, modulation of MAPK8 activity holds therapeutic potential for neurodegenerative diseases.

High Purity


Fig1. SDS-PAGE (MAPK8-1729H)


(Sorabh Kapoor, 2014)

Fig2. Changes in hepatic cell signaling 5 days after IP. A: Western blots from freshly isolated hepatocytes from three normal donor rats and from three donors at 5 days after IP. β-Tubulin was used as the loading control.


(Hsin-Han Hou, 2014)

Fig3. PGF-activated MAPK8 and MAPK14 signaling pathways are involved in PGF-induced autophagy. (A and B) BEAS-2B cells were pretreated with 100 ng/ml recombinant human PGF for 0 to 24 h. PGF-induced phosphorylation of MAPK8 and MAPK14 was assessed by western blot analysis for p-MAPK8 and p-MAPK14 (A) and the quantitative results are shown in (B).

MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayETS2;PIK3R1;GNG12;PAK6;PAK2;PRKACB;RAC2;FGFR3;RALGDS
Sphingolipid signaling pathwayPPP2R5D;S1PR5;TRAF2;MAPK3;GNAI3;TRP53;PLD2;RELA;ASAH1
Protein processing in endoplasmic reticulumSELS;CAPN1B;UBQLN1;DNAJB11;DNAJB12A;DNAJC5;BAX;CALR;SAR1B
Osteoclast differentiationMAPK9;IL1A;LILRB4;LCK;PLCG2;MAPK3;TNF;SOCS1;MAPK1
Toll-like receptor signaling pathwayIL12A;STAT1A;IFNA3;TLR4BB;IFNA17;PIK3R1;MAPK9;RAC1A;CCL3
NOD-like receptor signaling pathwayCARD9;MAPK14A;HSP90AA1.1;NFKBIAA;MAPK8B;HSP90AA1;CASP1;RIPK2;NFKBIA
RIG-I-like receptor signaling pathwayIFNA7;DDX3X;ATG5;DHX58;TRAF6;Ifna15;MAPK11;TBK1;IFNE
Fc epsilon RI signaling pathwayTNF;MAPK9;MAPK3;PLCG2;IL4;IL5;PLA2G4D;MAPK1;SYK
TNF signaling pathwayCasp3;MAP2K6;PIK3CA;IL18R1;CREB3L1;PIK3CD;MAPK3;CXCL3;CXCL2
Neurotrophin signaling pathwayPSEN1;NTRK2;MAP2K7;IRAK1;ZNF274;MAP3K1;SH2B1;PIK3R1;MAP2K5
Retrograde endocannabinoid signalingGABRB1;GNG2;GRIA4;GABRD;PRKACB;GABRA2;GNG5;GABRA5;GNAO1
Inflammatory mediator regulation of TRP channelsMAPK8;CALM3;PPP1CB;CYP2C55;HTR2B;ALOX12;ASIC2;NGF;CAMK2G
GnRH signaling pathwayPTK2B;SRC;CAMK2G;Adcy4;ADCY2B;PTK2BB;SOS1;CALM3;PLA2G4F
Progesterone-mediated oocyte maturationRPS6KA1;INS2;CPEB1;PIK3R3;CPEB4;FZR1;ADCY1B;PDE3B;AKT2
Prolactin signaling pathwayPRP2;SOCS3;STAT5B;PIK3CD;RELA;ESR2;TH;SIRPA;GSK3B
Adipocytokine signaling pathwayNFKB1;SLC2A1;NFKBIE;CPT1C;RXRGB;RXRBA;PRKAA2;NFKBIA;SOCS3
Non-alcoholic fatty liver disease (NAFLD)NDUFB9;IRS1;FASLG;UQCRB;GSK3B;TNFRSF1A;NDUFA8;NDUFB11;NDUFC2-KCTD14
Epithelial cell signaling in Helicobacter pylori infectionATP6AP1;PLCG2;ATP6V1G1;CXCR1;NOD1;MAPK11;ATP6V1C1;MAPK8;SRC
Salmonella infectionIFNG1-2;ROCK2;ARPC5L;MYH10;MAPK8A;CCL3;PFN2L;RAC1A;LBP
Chagas disease (American trypanosomiasis)GNAI1;MAPK8;IRAK1;C3;Il2;GNAI2;CALR;TICAM1;MAPK10
Hepatitis BCASP8;IL-8;Fasl;TLR4;MAP2K4;BAX;ATF4;NRAS;EP300
Epstein-Barr virus infectionHSPB1;FCER2;HLA-DPB1;HLA-DRB4;PIK3R5;HLA-DRB5;FGR;XPO1;TRAF2
Pathways in cancerITGB1;STAT5B;SMO;Adcy4;TPM3;PLCG2;Ar;WNT3;CDH1
Colorectal cancerSMAD2;TRP53;PIK3R5;PIK3R3;TGFBR2;RAC1;MAP2K1;RAC2;RHOA
Choline metabolism in cancerPIP5K1C;FOS;SLC44A1;HRAS;PDPK1;CHKA;PIK3CB;MAP2K2;PLA2G4B

MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

Function Related Protein
JUN kinase activityMAPK10;MAPK8;ALPK2;MAPK9
histone deacetylase bindingRELA;RAD9A;CEBPB;ANKRD1;YWHAB;TOP2A;NIPBL;PKN2;KPNA2
histone deacetylase regulator activityMAPK8;NCOR1;TP53;TRP53
protein bindingERLEC1;USP2;AICDA;PPP1R37;RUSC1;KLF10;COG5;BAZ1B;BTF3L4
protein serine/threonine kinase activityCSNK1G3;LATS1;PRKCD;PIM2;FAM20C;MAPK8B;PKZ;AURKA;STK10

MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.


Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is MAPK8 involved in inflammatory processes? 02/23/2023

Yes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Can MAPK8 inhibitors potentially be used in treating Alzheimer's disease? 05/18/2022

Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.

How is MAPK8 protein expression assessed in clinical research? 07/21/2020

MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.

How does MAPK8 influence neuronal function and neurodegeneration? 08/01/2019

MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.

How does MAPK8 influence cellular apoptosis? 06/09/2016

MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.

Customer Reviews (3)

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    I am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.


      By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.


        the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.

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