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Official Full Name mitogen-activated protein kinase 8
Background The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
Synonyms MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC; Stress-activated protein kinase JNK1
    • Type:
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
    Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
    Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
    Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
    Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
    Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
    Human MAPK8-781H Recombinant Human MAPK8, GST tagged Insect Cell GST
    Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST
    Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
    Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7
    Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
    Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7
    Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A

    mapk8 involved in several pathways and played different roles in them. We selected most pathways mapk8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with mapk8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNG2A; PPM1A; HSC70; MAPK6; RRAS2; PPP3CB; GNA12A; MAP4K4; ARRB2; FLNA
    ErbB signaling pathway ERBB3; MAPK10; NRG2; RPS6KB1B; GSK3AA; MAP2K2; PIK3R1; EGFRA; CAMK2G1; PRKCBB
    Ras signaling pathway HTR7; Fasl; PLA2G4C; PLCG2; PRKACB; RAC2; RGL1; IGF1R; PIK3R5; INS
    cAMP signaling pathway CAMK4; CAMK2A; NFATC1; ATP2B4; SLC9A1; CALM4; RAP1A; PDE4A; PIK3CA; CREB3L2
    FoxO signaling pathway PCK1; PIK3CD; MAP2K2A; FOXO1B; INS1; MAPK8B; INSRB; PIK3R3; HOMER2; PTENB
    Sphingolipid signaling pathway PPP2R3C; AKT1; GNA12; FCER1A; PPP2R5A; GNAQ; FCER1G; NOS3; ROCK2; RAC2
    Protein processing in endoplasmic reticulum MAN1C1; DAD1; CALR; STT3B; EDEM1; UBE2G1A; CRYAA; RNF5; DNAJB2; TXNDC5
    Wnt signaling pathway NKD1; DKK1B; FBXW11B; APC; NFATC1; FZD2; RAC1; VANGL1; WNT11; WNT10B
    Osteoclast differentiation SPI1; LILRB4; TRAF6; PLCG2; MAPK1; MAPK3; NCF4; IFNAR1; PIK3CG; PPP3CC
    Toll-like receptor signaling pathway MAP2K1; MAPK8B; IL12B; IFNB1; IFNA8; TMED7-TICAM2; MAPK12A; MAPK3; IFNA3; NFKBIA
    NOD-like receptor signaling pathway MAPK12A; MAPK14B; IKBKG; CXCL8B.3; CASP1; NLRP3; HSP90AA1; ERBB2IP; CASPA; NFKBIAA
    RIG-I-like receptor signaling pathway IFNK; RIPK1; IL8L1; ATG5; TBKBP1; MAPK11; DAK; MAVS; IFNA1; IL-8
    Fc epsilon RI signaling pathway IL13; BTK; MAPK12; PIK3CD; SYK; RAF1; PLCG2; FCER1G; MAP2K3; MAPK1
    TNF signaling pathway MAP2K7; MAPK11; PIK3CB; RIPK1; MMP14; MAP3K7; FAS; ATF4; PIK3CG; PIK3R1
    Neurotrophin signaling pathway CAMK2G; NTF4; RPS6KA1; ZNF274; CALML3; MAPK10; BAD; SOS1; TRAF6; MAP2K5
    Retrograde endocannabinoid signaling GNAO1; NAPEPLD; GNG10; ITPR1; FAAH; GNG7; PLCB2; GABRA3; GNGT2; GABRD
    Dopaminergic synapse GNAO1; GNG3; MAOA; PRKACG; ARRB2; CREB3; PPP3CC; PRKCA; SLC6A3; MAPK12
    Inflammatory mediator regulation of TRP channels PRKCG; PIK3R1; PIK3CG; PRKCB; ITPR3; CYP2C38; CALML5; PIK3R3; HTR2C; CALM1
    Insulin signaling pathway TSC1A; PHKG1; TSC1B; IRS2; CALM2B; ACACA; MKNK2B; SOCS4; PRKAA2; MAPK8B
    Progesterone-mediated oocyte maturation INSB; RPS6KA6; MAD1L1; MAPK8A; PIK3R3; AKT2L; PIK3CB; ADCY2B; ADCY1B; PRKACAB
    Prolactin signaling pathway PRP2; PIK3R5; SHC4; FOS; NFKB1; MAPK9; MAP2K2; PPIB; MAPK8; CSH
    Adipocytokine signaling pathway NFKBIAB; ACSL3B; MAPK10; RXRGB; G6PCA.1; STK11; ACSL5; PTPN11B; ACSL1; IRS4
    Type II diabetes mellitus PIK3R5; PRKCD; MAPK10; PIK3CG; ADIPOQ; PIK3R2; HKDC1; SOCS4; PKM2; SLC2A2
    Insulin resistance PRKAA2; PPP1R3C; RPS6KB1; G6PC; G6PC3; SLC2A1; PRKAB1; PPP2R4; PIK3CG; PTENB
    Non-alcoholic fatty liver disease (NAFLD) Il6ra; UQCRFS1; NDUFS2; NDUFA6; COX7B2; NDUFV1; COX5A; PIK3CD; AKT1; UQCRC1
    Epithelial cell signaling in Helicobacter pylori infection TJP1; ATP6V0B; IL-8; MAPK10; MAPK11; ATP6V0A4; ATP6V1F; MAPK8; NFKB1; MAP3K14
    Shigellosis IKBKG; RHOG; MAPK8; ACTG1; ELMO3; MAD2L2; CDC42; PFN1; MAPK1; IKBKB
    Salmonella infection CCL3L3; MAPK10; MAPK3; PFN1; MYH10; PFN2; NLRC4; IFNG; ACTB1; MAPK13
    Pertussis RHOA; Il23a; Il12b; CXCL5; MAPK10; CALML5; CD14; LY96; CALM1; CALM3; ITGB1
    Chagas disease (American trypanosomiasis) PLCB1; C1QA; GNA15; TGFBR2; PIK3CD; PIK3CG; C1QB; MAPK10; CD247; IL12B
    Toxoplasmosis TLR4; AKT1; H2-AA; TRAF6; HLA-DRB1; IRAK4; SOCS1; MAPK3; BCL2; GNAI1
    Tuberculosis IL18; IFNA6; CORO1A; PPP3R2; TRADD; IFNA1; MAPK8; IFNA16; IFNA14; TLR2
    Hepatitis C IFNA14; PPP2R1A; IFN-a; PIK3R1; IFNA8; CLDN23; Ifna15; CLDN1; IRF7; IFNA7
    Hepatitis B IFNA14; IFNA16; CASP8; IFNA2; CREB3L1; STAT6; IFNA17; CASP10; EP300; NFKBIA
    Influenza A IL1B; TNFRSF1A; IFNB1; STAT2; IFIH1; FAS; PRSS2; PRSS3; EP300; MAPK11
    HTLV-I infection RANBP1; CANX; ANAPC7; PPP3R2; WNT1; POLD4; IL1R2; Il2; ITGAL; HLA-DRB3
    Herpes simplex infection MHC1UEA; IRF3; SOCS3B; CUL1; CD74A; NFKBIAB; TAF9B; IL12A; SRSF5; SRSF7A
    Epstein-Barr virus infection STAT3; POLR2G; RBPJL; HDAC5; NFKB1; HLA-DRA; HLA-DQA2; HDAC1; IKBKB; TRAF1
    Pathways in cancer PLEKHG5; KRAS; HSP90B1; GNA11; TRAF6; MTOR; FZD2; BMP4; FAS; RAC1
    Colorectal cancer TCF7; AKT1; BAX; LEF1; TRP53; BCL2; SMAD4; RAC3; PIK3CD; MAPK8
    Pancreatic cancer RB1; ARAF; RAD51; PIK3R3; CDC42; PIK3CA; TGFB1; TGFB3; RELA; STAT1
    Choline metabolism in cancer PDPK1; PLA2G4A; PLCG1; LYPLA1; CHKA; PPAP2A; PLA2G4D; FOS; HIF1A; DGKE

    mapk8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mapk8 itself. We selected most functions mapk8 had, and list some proteins which have the same functions with mapk8. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activity MAPK10; MAPK8; ALPK2; MAPK9
    enzyme binding HDAC1; SPDL1; SLPI; HLCS; HDAC6; CFTR; U2AF2; TSPAN10; DAXX; TRP53
    histone deacetylase binding SFPQ; CDC20; SP1; RAD9A; NKX3-1; ZNF703; CBX5; FOXP3; ZFP932; MAGEA1
    histone deacetylase regulator activity NCOR1; TRP53; TP53; MAPK8
    protein binding NUSAP1; EFNB2; TKT; METTL9; PIAS2; BPIFA2; ZNF581; COX6B2; UTP23; RPL13
    protein serine/threonine kinase activity MAST2; STK35L; PRKCE; ACVR1; MLKL; CLK1; DYRK3; CDK14; RPS6KAL; TAF1L

    mapk8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mapk8 here. Most of them are supplied by our site. Hope this information will be useful for your research of mapk8.


    Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
    Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).

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