Active Recombinant Full Length Mouse Mapk8 Protein, GST tagged

• Cat.No.: Mapk8-338M
• Product Overview: Recombinant full-length mouse JNK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Mouse
• Source: Insect Cells
• Tag: GST
• Protein Length: 1-464 aa
• Description: Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including generation of neurons; integrin-mediated signaling pathway; and positive regulation of protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is active in Schaffer collateral - CA1 synapse and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).
• Molecular Mass: 70 kDa
• Bio-activity: 105 nmol/min/mg
• Purity: The purity of JNK1 was determined to be >90% by densitometry.
• Stability: One year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Concentration: 0.1 μg/μL
• Shipping: Dry ice

Gene Information

• Gene Name: Mapk8 mitogen-activated protein kinase 8 [ Mus musculus (house mouse) ]
• Official Symbol: Mapk8
• Synonyms: Mapk8; mitogen-activated protein kinase 8; JNK; JNK1; Prkm8; SAPK1; mitogen-activated protein kinase 8; JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; c-Jun N-terminal kinase 1; protein kinase mitogen-activated 8; stress-activated protein kinase JNK1; EC 2.7.11.24
• Gene ID: 26419
• mRNA Refseq: NM_016700
• Protein Refseq: NP_057909
• UniProt ID: Q61831