• Official Full Name

    mitogen-activated protein kinase-activated protein kinase 5

  • Overview

    The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Synonyms

    MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; PRAK; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase; MK5; MK-5; MAPKAP-K5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • S.frugiperda
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPKAPK5-161HFL Active Recombinant Full Length Human MAPKAPK5 Protein, N-His-tagged Sf21 His Full Length
Human MAPKAPK5-162HFL Unactive Recombinant Full Length Human MAPKAPK5 Protein, N-His-tagged Sf21 His Full Length
Human MAPKAPK5-1056H Recombinant Human Mitogen-activated Protein Kinase-Activated Protein Kinase 5, GST-tagged Sf9 Insect Cell GST
Human MAPKAPK5-642H Recombinant Human MAPKAPK5 Protein, His-tagged E.coli His
Human MAPKAPK3-695H Recombinant Human MAPKAPK5, GST-His S.frugiperda His/GST
Human MAPKAPK5-736H Recombinant Human MAPKAPK5 E.coli N/A
Human MAPKAPK5-1888H Recombinant Human Mitogen-Activated Protein Kinase-Activated Protein Kinase 5, His-tagged Insect Cell His
Human MAPKAPK5-567H Recombinant Human MAPKAPK5 protein, His&GST-tagged Insect Cells His/GST Met1-Gln471
Human MAPKAPK5-432HCL Recombinant Human MAPKAPK5 cell lysate Insect Cell N/A
Human MAPKAPK5-1216H Recombinant Human MAPKAPK5 protein, GST-tagged E.coli GST 232-471 aa
Human MAPKAPK5-1303H Recombinant Human MAPKAPK5 Protein (S2-Q473), Tag Free Insect Cell No tag S2-Q473
Human MAPKAPK5-8937HF Active Recombinant Full Length Human MAPKAPK5 Protein, GST-tagged Insect (sf21) GST 1-471
Human MAPKAPK5-1304H Recombinant Human MAPKAPK5 Protein (S2-Q473), GST tagged Insect Cell GST S2-Q473
Mouse MAPKAPK5-9546M Recombinant Mouse MAPKAPK5 Protein Mammalian Cell His
Mouse MAPKAPK5-5358M Recombinant Mouse MAPKAPK5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAPKAPK5-5358M-B Recombinant Mouse MAPKAPK5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MAPKAPK5-2675R Recombinant Rhesus monkey MAPKAPK5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAPKAPK5-2495R Recombinant Rhesus Macaque MAPKAPK5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAPKAPK5-2495R-B Recombinant Rhesus Macaque MAPKAPK5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAPKAPK5-485Z Recombinant Zebrafish MAPKAPK5 Mammalian Cell His
Chicken MAPKAPK5-4476C Recombinant Chicken MAPKAPK5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MAPKAPK5 involved in several pathways and played different roles in them. We selected most pathways MAPKAPK5 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPKAPK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MAPKAPK5 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, calcium-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPKAPK5 itself. We selected most functions MAPKAPK5 had, and list some proteins which have the same functions with MAPKAPK5. You can find most of the proteins on our site.

Function Related Protein
MAP kinase kinase activityMAP2K2A;MAP3K20;MAPK14;MAP2K2;MAP2K7;ALPK2;SBK3;MAPKAPK5;LRRK2
calcium-dependent protein serine/threonine kinase activityMAPKAPK2A;MAPKAPK5;MKNK2;MKNK1;CAMK4;MAPKAPK2B;CAMK1GB;MKNK2B;MKNK2A
calmodulin-dependent protein kinase activitySLC14A2;CAMK2B1;MKNK2B;ITPKA;CAMKK1;CAMK4;MAPKAPK2A;MYLK3;MAPKAPK5
mitogen-activated protein kinase bindingPTPRJ;MAPKAPK2B;MAPKAPK5;TPR;TNIP1;DUSP2;MAPK7;ABL1;GTF2I
p53 bindingAXIN1;TRIM29;SMARCB1;BRD4;EP300;RNF20;ZFP346;MSX1;MDM2
protein bindingGYPB;ZCCHC11;C16orf48;EYA4;TAF1;SIGLEC8;CTAGE5;ARPC4;FASTK
protein serine/threonine kinase activityMAP4K2;LATS1;CDK11B;MAPK8B;MAP2K6;STK24;C9orf96;PINK1;MAP4K5
signal transducer activityCC2D1A;GPR183B;AKAP13;S1PR3A;OLFR1013;MRGPRA7;TRAF2;HMOX1;S100A9

MAPKAPK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPKAPK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPKAPK5.

MAPK6; saicar; TP53; HSPB1; PKM; SRPK2; SRPK1; MAPK1; MAPK9; EIF4EBP1; RPL13; TAB1; MAPK14

Research Area

Related articles

Lee, WJ; Ou, HC; et al. Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. JOURNAL OF VASCULAR SURGERY 52:1290-1300(2010).
Jamesdaniel, S; Ding, DL; et al. Analysis of Cochlear Protein Profiles of Wistar, Sprague-Dawley, and Fischer 344 Rats with Normal Hearing Function. JOURNAL OF PROTEOME RESEARCH 8:3520-3528(2009).
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