Recombinant Human Mitogen-activated Protein Kinase-Activated Protein Kinase 5, GST-tagged
Cat.No. : | MAPKAPK5-1056H |
Product Overview : | Recombinant full-length human MAPKAPK5 was expressed by baculovirus in Sf9 insect cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MAPKAPK5-1056H |
Description : | MAPKAPK5 is a member of the serine/threonine kinase family that responds to cellular stress and proinflammatory cytokines. MAPKAPK5 is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta (1). MAPKAPK5 is activated in HeLa cells in response to cellular stress and proinflammatory cytokines. MAPKAPK5 activity is regulated by p38-alpha and p38-beta both in vitro and in vivo, and thr-182 is the regulatory phosphorylation site of MAPKAPK5 (2). In vitro, MAPKAPK5 kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 79 kDa |
Expression System : | Sf9 insect cells using baculovirus. |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 172 nmol/min/mg |
Purity : | > 80% |
Concentration : | 0.1 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | MAPK signaling pathway |
Gene Name : | MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 [ Homo sapiens ] |
Official Symbol : | MAPKAPK5 |
Synonyms : | MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; PRAK; EC 2.7.11.1 |
Gene ID : | 8550 |
mRNA Refseq : | NM_003668 |
Protein Refseq : | NP_003659 |
MIM : | 606723 |
UniProt ID : | Q8IW41 |
Chromosome Location : | 12q24.12-q24.13 |
Function : | ATP binding; MAP kinase kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity |
Products Types
◆ Recombinant Protein | ||
MAPKAPK5-5358M | Recombinant Mouse MAPKAPK5 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPKAPK5-1304H | Recombinant Human MAPKAPK5 Protein (S2-Q473), GST tagged | +Inquiry |
MAPKAPK5-1303H | Recombinant Human MAPKAPK5 Protein (S2-Q473), Tag Free | +Inquiry |
MAPKAPK5-2495R | Recombinant Rhesus Macaque MAPKAPK5 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPKAPK5-567H | Recombinant Human MAPKAPK5 protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
MAPKAPK5-432HCL | Recombinant Human MAPKAPK5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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