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Official Full Name mediator complex subunit 4
Background This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms MED4; mediator complex subunit 4; mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae) , VDRIP, vitamin D receptor interacting protein; mediator of RNA polymerase II transcription subunit 4; DRIP36; HSPC126; TRAP36; Activator-recruited cofactor 36 kDa component; ARC36; FLJ10956; MED4_HUMAN; Mediator of RNA polymerase II transcription, subunit 4 homolog; OTTHUMP00000018390; OTTHUMP00000018391; OTTHUMP00000018392; RP11-90M2.2; TRAP/SMCC/PC2 subunit p36 subunit; VDRIP; Vitamin D3 receptor-interacting protein complex 36 kDa component
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED4-2406H Recombinant Human Mediator Complex Subunit 4, His-tagged E.coli His
    Human MED4-2740H Recombinant Human MED4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MED4-29557TH Recombinant Human MED4, His-tagged E.coli His
    Human MED4-30188TH Recombinant Human MED4, His-tagged E.coli His
    Human MED4-4381HCL Recombinant Human MED4 293 Cell Lysate HEK293 N/A
    Human MED4-4467H Recombinant Human MED4 Protein, GST-tagged Wheat Germ GST
    Mouse Med4-4021M Recombinant Mouse Med4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MED4-9704M Recombinant Mouse MED4 Protein Mammalian Cell His
    Rat MED4-3639R Recombinant Rat MED4 Protein Mammalian Cell His
    Rhesus Macaque MED4-2727R Recombinant Rhesus monkey MED4 Protein, His-tagged Mammalian Cell His
    Zebrafish MED4-2604Z Recombinant Zebrafish MED4 Mammalian Cell His

    MED4 involved in several pathways and played different roles in them. We selected most pathways MED4 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway SLC16A2; GATA4; PIK3CG; CASP9; PFKFB2; ATP1B1; ITGB3; SIN3A; MED24; THRB

    MED4 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED4 itself. We selected most functions MED4 had, and list some proteins which have the same functions with MED4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity MED18; MED9; MED7; MED22; MED31; MED8; MED21; MED26; MED1; MED4
    ligand-dependent nuclear receptor transcription coactivator activity MED24; SLC30A9; MED17; CCAR1; PSMC3IP; TSG101; PPARG; ZMIZ2; PKN1; MED14
    protein binding SH2D1A; AK8; DES; ASCL3; STAMBPL1; pab1; MAGED1; SLAMF7; SETD8; HIST1H2AL
    receptor activity UBXN6; TNPO3; CADM2; OR3A2; OGFRL2; TRAM1; THRAP3; FPR1; ADIPOR1B; NLGN4B
    thyroid hormone receptor binding MED12; NCOA3; NR0B2; ZNHIT3; TRIP6; MED24; MED1; TAF11; FUS; MED4
    transcription cofactor activity TRIP13; LDB1B; PSMC5; LDB2A; MED12; THRAP3; ZNF865; SUPT20H; IRF3; NSD1
    vitamin D receptor binding TAF11; MED17; THRAP3; MED4; RXRA; RUNX2B; MED30; SNW1; TAF7; MED16

    MED4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED4.

    MED10; MED9; MED19; MED26

    Gomez-Garcia, MR; Serrano, A; et al. Expression studies of two paralogous ppa genes encoding distinct Family I pyrophosphatases in marine unicellular cyanobacteria reveal inactivation of the typical cyanobacterial gene. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295:890-897(2002).
    Garczarek, L; van der Staay, GWM; et al. Isolation and characterization of photosystem I from two strains of the marine oxychlorobacterium Prochlorococcus. PHOTOSYNTHESIS RESEARCH 56:131-141(1998).
    Partensky, F; LaRoche, J; et al. The divinyl-chlorophyll a/b-protein complexes of two strains of the oxyphototrophic marine prokaryote Prochlorococcus - Characterization and response to changes in growth irradiance. PHOTOSYNTHESIS RESEARCH 51:209-222(1997).

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