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Recombinant Human MMP12 protein, His-tagged

Cat.No. : MMP12-06H
Product Overview : Recombinant Human MMP12(Ala290-Gly469) fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 23.2kDa
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : MMP12 matrix metallopeptidase 12 (macrophage elastase) [ Homo sapiens ]
Official Symbol : MMP12
Synonyms : MMP12; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); macrophage metalloelastase; HME; macrophage elastase; matrix metalloproteinase-12; ME; MME; MMP-12; MGC138506;
Gene ID : 4321
mRNA Refseq : NM_002426
Protein Refseq : NP_002417
MIM : 601046
UniProt ID : P39900
Chromosome Location : 11q22.3
Pathway : Matrix Metalloproteinases, organism-specific biosystem;
Function : calcium ion binding; endopeptidase activity; metalloendopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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