Active Native Human MMP8 Protein

• Cat.No.: MMP8-1656H
• Product Overview: Native human MMP8 protein was isolated from stimulated human neutrophil granulocytes (buffy coat)

Specification

• Description: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
• Source: Neutrophil granulocytes
• Species: Human
• Form: Liquid
• Bio-activity: ≥60 mU/mg protein. One unit is defined as the amount of enzyme that hydrolyzes 1 μmol 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH per min. at 37 centigrade, pH 7.0.
• Molecular Mass: ~85 kDa
• Purity: ≥90% by SDS-PAGE
• Stability: Stable for 1 week when stored at +4 centigrade and for serveral weeks when stored at -20 centigrade.
• Storage: At -80 centigrade
• Concentration: 100 μg/ml
• Storage Buffer: In 50mM TRIS-HCl, pH 7.0, containing 200mM NaCl, 5mM CaCl2, 1μM ZnCl2, 0.05% BRIJ 35, and 0.05% sodium azide.
• Handling: Avoid freeze/thaw cycles.
• Shipping: Shipped on Dry Ice

Gene Information

• Gene Name: MMP8 matrix metallopeptidase 8 [ Homo sapiens (human) ]
• Official Symbol: MMP8
• Synonyms: MMP8; matrix metallopeptidase 8; 3.4.24.34; HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; collagenase 2; matrix metalloproteinase 8 (neutrophil collagenase); matrix metalloproteinase-8; EC 3.4.24.34
• Gene ID: 4317
• mRNA Refseq: NM_002424
• Protein Refseq: NP_002415
• MIM: 120355
• UniProt ID: P22894

Reviews

04/03/2022

The use of MMP8 as a catalyst can significantly increase the rate and yield of chemical reactions with impressive high catalytic efficiency.

09/14/2021

MMP8 is really impressive, the results of every experiment are very consistent, you can see that its production process is very careful.

03/20/2021

MMP8 are inexpensive to prepare and cost-effective, making them ideal for our study.

Q&As

What signaling pathways does the MMP8 protein interact with?

The MMP8 protein interacts with a variety of signaling pathways, including TNF-α, TGF-β, Wnt, and NF-κB.

What drugs interact with the MMP8 protein?

A number of inhibitors and modulators of MMP8 protein have been developed for the regulation of MMP8 activity and the treatment of related diseases.

Why does MMP8 protein play a role in tissue repair?

The MMP8 protein is involved in the tissue repair and wound healing process, by degrading damaged tissue and supporting the formation of new tissue.

What is the mechanism of action of MMP8 protein in inflammatory response?

MMP8 protein is involved in regulating the production of inflammation-related molecules and cell infiltration, promoting the occurrence and maintenance of inflammatory response.

Does MMP8 have a role in post-traumatic recovery?

MMP8 protein is involved in the inflammatory and remodeling processes of post-traumatic wound healing, contributing to wound repair and tissue regeneration.

Does the MMP8 protein study have implications for new drug development?

MMP8 protein plays an important role in the occurrence and progression of diseases, and studying the regulatory mechanism of MMP8 protein is helpful for the development of new drugs, such as inhibitors targeting MMP8 protein may be applied to the treatment of related diseases