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MUC5B

Official Full Name

mucin 5B, oligomeric mucus/gel-forming
Overview

This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
Synonyms

MUC5B; mucin 5B, oligomeric mucus/gel-forming; MUC5, mucin 5, subtype B, tracheobronchial; mucin-5B; MG1; tracheobronchial; Cervical mucin; Cervical mucin MUC5B; High molecular weight salivary mucin MG1; MUC-5B; MUC5; MUC5B_HUMAN; MUC9; Mucin 5 subtype B, tracheobronchial; Mucin 5B; Mucin 5B oligomeric mucus/gel forming; Mucin-5 subtype B; Sublingual gland mucin; OTTHUMP00000233052; mucin-5 subtype B, tracheobronchial; mucin 5, subtype B, tracheobronchial;

Type

Recombinant Proteins

Species

Cattle
Human
Mouse
Rat

Source

E.coli
Wheat Germ

Tag

GST
His
Myc
His|GST
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MUC5B-784H	Recombinant Human MUC5B protein, His-tagged	E.coli	His	Lys5366~Val5444	Inquiry
Human	MUC5B-1030H	Recombinant Human MUC5B, GST-tagged	Wheat Germ	GST		Inquiry
Human	MUC5B-2465H	Recombinant Human MUC5B Protein, His-tagged	E.coli	N-His	Cys5653-Val5762	Inquiry
Human	MUC5B-4400H	Recombinant Human MUC5B protein, His&Myc-tagged	E.coli	His&Myc	4186-4295aa	Inquiry
Human	MUC5B-5149H	Recombinant Human MUC5B Protein (Ser5657-Ala5756), N-GST tagged	E.coli	N-GST	Ser5657-Ala5756	Inquiry
Mouse	Muc5b-785M	Recombinant Mouse Muc5b protein, His-tagged	E.coli	His	Ala75~Leu295	Inquiry
Rat	Muc5b-788R	Recombinant Rat Muc5b protein, His & GST-tagged	E.coli	His/GST	Ala898~Ile1002 (Accession # D3ZAU0)	Inquiry
Rat	Muc5b-786R	Recombinant Rat Muc5b protein, His & GST-tagged	E.coli	His/GST	Arg3513~Gly3611 (Accession # D3ZAU0)	Inquiry
Rat	Muc5b-787R	Recombinant Rat Muc5b protein, His & GST-tagged	E.coli	His/GST	Lys3667~Leu3771 (Accession # D3ZAU0)	Inquiry
Cattle	MUC5B-783C	Recombinant Cattle MUC5B protein, His-tagged	E.coli	His	Gln6489~Tyr6632	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MUC5B Related Articles

MUC5B involved in several pathways and played different roles in them. We selected most pathways MUC5B participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Salivary secretion	ATP1B1;CALM4;LYZ1;PRKACB;CD38;PRKACG;LPO;GUCY1B3;CALM3

MUC5B has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC5B itself. We selected most functions MUC5B had, and list some proteins which have the same functions with MUC5B. You can find most of the proteins on our site.

Function	Related Protein
protein binding	ZNF488;ING5;ARL4D;EPC1;ZNF256;SLC9A1;LDLR;RAMP2;PLP2

MUC5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC5B here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC5B.

Yunus, MHM; Siang, KC; et al. The effects of human serum to the morphology, proliferation and gene expression level of the respiratory epithelium in vitro. TISSUE & CELL 46:233-240(2014).

Henderson, AG; Ehre, C; et al. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. JOURNAL OF CLINICAL INVESTIGATION 124:3047-3060(2014).