NEU4

  • Official Full Name

    sialidase 4

  • Overview

    The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

  • Synonyms

    NEU4;sialidase 4;sialidase-4;neuraminidase 4;N-acetyl-alpha-neuraminidase 4;FLJ35928;MGC18222;MGC102757

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • GST
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    NEU4 involved in several pathways and played different roles in them. We selected most pathways NEU4 participated on our site, such as Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein,Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins CCT6A,MPDU1A,CMA1,IGFBP6A,DDX11,PHC2,GALNT5,GPR119,DMBT1,MFGE8
    Metabolism of lipids and lipoproteins DGAT1B,SLC25A20,NEU3,PEMT,CHAT,MED20,NFYBB,EBP,GDF1,THEM5
    Post-translational protein modification SPON1,ADAMTS8,CNIH,PPP6R3,MUC21,ADAMTS1,ADAMTS3,SEC23IP,CNIH2,SPON1A
    Metabolism DPEP2,CYP2R1,ABHD4,CYP2A13,KCNC2,SACM1LB,GRHL1,CYP2AD6,FMODA,CYP2K19
    Asparagine N-linked glycosylation NSFA,ALG10B,GOLGA2,TRAPPC4,MIA3,CNIH3,CSNK1D,NANP,CNIH,MGAT4B
    Glycosphingolipid metabolism ARSK,ARSD,ARSE,NEU3,ARSI,ARSH,CPTP,GLTPA,GLTP,GLTPD1
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein NEU3,ST8SIA2,ALG10B,DPAGT1,ST3GAL3A,GNE,ST6GAL2B,ST8SIA3,ST6GALNAC2,ST6GALNAC1.2
    Other glycan degradation FUCA2,GBA,NEU1,GLB1,NEU3.2,HEXDC,ENG-1,GBA2,NEU3,AGA

    Protein Function

    NEU4 has several biochemical functions, for example, exo-alpha-(2->3)-sialidase activity,exo-alpha-(2->6)-sialidase activity,exo-alpha-(2->8)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU4 itself. We selected most functions NEU4 had, and list some proteins which have the same functions with NEU4. You can find most of the proteins on our site.

    Function Related Protein
    exo-alpha-(2->3)-sialidase activity NEU2,NEU1,NEU3
    exo-alpha-(2->8)-sialidase activity NEU1,NEU3,NEU2
    exo-alpha-sialidase activity NEU3.3,NEU3.2,ST3GAL5L,NEU3.5,NEU3,NEU3.4,NEU3.1,NEU1
    protein binding PALB2,Car8,ICAM5,RAB7A,ARMCX1,MYH11,TIGIT,MC3R,C11orf65,PRKCZ
    exo-alpha-(2->6)-sialidase activity NEU1,NEU2,NEU3

    Interacting Protein

    NEU4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU4.

    MDFI;RHOXF2;PLSCR1;Dlg4;RBPMS

    Resources

    References

    • Alghamdi, F; Guo, M; et al. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. CELLULAR SIGNALLING 26:1355-1368(2014).
    • Itokazu, Y; Yu, RK; et al. Amyloid beta-Peptide 1-42 Modulates the Proliferation of Mouse Neural Stem Cells: Upregulation of Fucosyltransferase IX and Notch Signaling. MOLECULAR NEUROBIOLOGY 50:186-196(2014).

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