NR4A2
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Official Full Name
nuclear receptor subfamily 4, group A, member 2
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Overview
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
NR4A2; nuclear receptor subfamily 4, group A, member 2; NOT; RNR1; HZF-3; NURR1; TINUR; nuclear receptor subfamily 4 group A member 2; nuclear receptor related 1; T-cell nuclear receptor NOT; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; intermediate-early receptor protein; immediate-early response protein NOT; nur related protein-1, human homolog of; transcriptionally-inducible nuclear receptor; NGFI-B/nur77 beta-type transcription factor homolog; transcriptionally inducible nuclear receptor related 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
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- Rat
- Rhesus Macaque
- E.coli
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- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- NR4A2 Related Articles
- NR4A2 Related Research Area
NR4A2 involved in several pathways and played different roles in them. We selected most pathways NR4A2 participated on our site, such as Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | GNAS;HSD3B1;CYP11B2;PRKCG;PDE2A;CALML3;KCNK9;NR4A2;AKR1C1 |
NR4A2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR4A2 itself. We selected most functions NR4A2 had, and list some proteins which have the same functions with NR4A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | UPF1;ESR2B;KLF14;ZNF471;HNRPDL;GLYR1;TOX4;HIST2H2AC;ERCC6 |
| RNA polymerase II core promoter sequence-specific DNA binding | SOX3;SFPI1;HEYL;GBX2;YAP1;HOXB3;TAL1;TP53;ZFP335 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | RORB;NR5A5;NR2F1A;NR2F6A;AHR2;HNF4G;PPARAB;NR5A1B;NR0B1 |
| glucocorticoid receptor binding | CEBPB;YWHAH;NRIP1;EP300;FKBP4;NR4A2;ETS2;GRIP1;STAT3 |
| protein binding | TRAF5;CTSL2;NCOR1;TGFBI;PPIL2;MTIF3;FREM2;DCAF8;BMPR2 |
| protein heterodimerization activity | JAM2A;TPD52L1;UGT1A4;HIST1H2AA;RAF1;PPP1CBL;HIST1H2BP;MAP3K7;MAFA |
| protein homodimerization activity | ACTN1;FAM109A;MYPOP;DMRTC1B;GPD1L;HES1;TBX1;PEX11A;IL6ST |
| retinoid X receptor binding | HMGA1;RARB;NCOA1;NCOR1;NR4A2;RARG;NR0B2;FUS;NR1H2 |
| steroid hormone receptor activity | OLFR78;RORA;NR1I2;NR4A2A;PAQR8;HNF4A;RORAB;RORCA;RARGB |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOXI1;TCF4;SMAD2;NFIC;TFE3B;TRP63;CAMTA2;KLF5;ATOH1 |
| zinc ion binding | DTNB;LRSAM1;RING1;ADAM32;MEP1A.1;BMP1;TRIM35-34;ZNF212;PHF1 |
NR4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR4A2.
TCEAL5; NDUFS5; OPA1; NEFM; FDX1; ZNF41; RAN; GTF2I; EIF3A; SUGP2; ANP32E; ZCCHC17; CISD1; BAZ1B
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