P2RY12 Protein


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Official Full Name purinergic receptor P2Y, G-protein coupled, 12
Background The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
Synonyms P2RY12; purinergic receptor P2Y, G-protein coupled, 12; P2Y purinoceptor 12; HORK3; P2Y12; SP1999; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His&Flag
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human P2RY12-1497H Recombinant Human P2RY12, GST-tagged E.coli GST
    Rat P2RY12-4234R Recombinant Rat P2RY12 Protein Mammalian Cell His
    Cynomolgus Monkey P2RY12-770C Recombinant Cynomolgus P2RY12 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque P2RY12-3272R Recombinant Rhesus monkey P2RY12 Protein, His-tagged Mammalian Cell His
    Human P2RY12-3491HCL Recombinant Human P2RY12 293 Cell Lysate HEK293 N/A
    Human P2RY12-3492HCL Recombinant Human P2RY12 293 Cell Lysate HEK293 N/A
    Human P2RY12-1103HFL Recombinant Human P2RY12 protein, His&Flag-tagged HEK293 His&Flag
    Human P2RY12-2459H Recombinant Human P2RY12 protein, His-tagged E.coli His
    Human P2RY12-2840H Recombinant Human P2RY12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse P2ry12-4638M Recombinant Mouse P2ry12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Kit-0917 CYP2B6 Blue Screening Kit N/A
    Kit-1470 P2RY12 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    P2RY12 involved in several pathways and played different roles in them. We selected most pathways P2RY12 participated on our site, such as Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Platelet activation GUCY1A3; TLN1; FCER1G; VASP; GNAS; PIK3CB; FYN; ACTB; ARHGAP35; VWF

    P2RY12 has several biochemical functions, for example, ADP receptor activity, G-protein coupled adenosine receptor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY12 itself. We selected most functions P2RY12 had, and list some proteins which have the same functions with P2RY12. You can find most of the proteins on our site.

    Function Related Protein
    ADP receptor activity P2RY12
    G-protein coupled adenosine receptor activity ADORA2A; ADORA2AB; ADORA2B; ADORA1; ADORA3; P2RY12; ADORA2AA
    guanyl-nucleotide exchange factor activity DOCK4B; RAPGEF4; P2RY12; EIF2B5; CHRM4; ARHGEF1B; GAPVD1; ARHGEF39; SH2D3A; TAGAP

    P2RY12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY12 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY12.

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