Recombinant Full Length Human P2RY12 Protein, C-Flag-tagged

• Cat.No.: P2RY12-590HFL
• Product Overview: Recombinant Full Length Human P2RY12 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 39.3 kDa
• AA Sequence: MQAVDNLTSAPGNTSLCTRDYKITQ VLFPLLYTVLFFVGLITNGLAMRIF FQIRSKSNFIIFLKNTVISD LLMILTFPFKILSDAKLGTGPLRTF VCQVTSVIFYFTMYISISFLGLITI DRYQKTTRPFKTSNPKNLLG AKILSVVIWAFMFLLSLPNMILTNR QPRDKNVKKCSFLKSEFGLVWHEIV NYICQVIFWINFLIVIVCYT LITKELYRSYVRTRGVGKVPRKKVN VKVFIIIAVFFICFVPFHFARIPYT LSQTRDVFDCTAENTLFYVK
  ESTLWLTSLNACLDPFIYFFLCKSF RNSLISMLKCPNSATSLSQDNRKKE QDGGDPNEETPMTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, GPCR, Transmembrane

Gene Information

• Gene Name: P2RY12 purinergic receptor P2Y12 [ Homo sapiens (human) ]
• Official Symbol: P2RY12
• Synonyms: HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
• Gene ID: 64805
• mRNA Refseq: NM_022788.5
• Protein Refseq: NP_073625.1
• MIM: 600515
• UniProt ID: Q9H244

Reviews

04/23/2019

As the most reliable assistant in my experiments, nothing surpasses this protein reagent.

10/30/2016

The manufacturer's reliability ensures that I can use it with complete peace of mind.

01/31/2016

The performance of this protein substance is truly remarkable! Its stability and accuracy instill confidence in my experimental results, and the manufacturer's quality control is highly dependable.