Recombinant Human P2RY12 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: P2RY12-2840H
• Product Overview: P2RY12 MS Standard C13 and N15-labeled recombinant protein (NP_073625) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 39.4 kDa
• AA Sequence: MQAVDNLTSAPGNTSLCTRDYKITQ VLFPLLYTVLFFVGLITNGLAMRIF FQIRSKSNFIIFLKNTVISDLLMIL TFPFKILSDAKLGTGPLRTFVCQVT SVIFYFTMYISISFLGLITIDRYQK TTRPFKTSNPKNLLGAKILSVVIWA FMFLLSLPNMILTNRQPRDKNVKKC SFLKSEFGLVWHEIVNYICQVIFWI NFLIVIVCYTLITKELYRSYVRTRG VGKVPRKKVNVKVFIIIAVFFICFV PFHFARIPYTLSQTRDVFDCTAENT LFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLKCPNSATSLSQD NRKKEQDGGDPNEETPMTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: P2RY12 purinergic receptor P2Y12 [ Homo sapiens (human) ]
• Official Symbol: P2RY12
• Synonyms: P2RY12; purinergic receptor P2Y, G-protein coupled, 12; P2Y purinoceptor 12; HORK3; P2Y12; SP1999; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor; ADPG-R; BDPLT8; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc)
• Gene ID: 64805
• mRNA Refseq: NM_022788
• Protein Refseq: NP_073625
• MIM: 600515
• UniProt ID: Q9H244