PARK2
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Official Full Name
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
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Overview
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. -
Synonyms
PARK2; PDJ; PRKN; AR-JP; LPRS2; parkin; parkinson protein 2, E3 ubiquitin protein ligase (parkin); E3 ubiquitin-protein ligase parkin; parkin 2; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; OTTHUMP00000017565; OTTHUMP00000017566; OTTHUMP00000017567; E3 ubiquitin ligase; parkinson disease protein 2; parkinson juvenile disease protein 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; EC 6.3.2.-;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PARK2 involved in several pathways and played different roles in them. We selected most pathways PARK2 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2F;UBE2D4;ANAPC5;UBA6;TRIP12;UBE2S;UBE3C;KLHL9;CDC16 |
| Protein processing in endoplasmic reticulum | DNAJC5GB;DNAJC1;LMAN1L;MAN1A1;RPN1;HSPA6;BAG1;HSPA5;CAPN1B |
| Parkinsons disease | UQCR11;NDUFS6;NDUFA4;NDUFA11;NDUFA2;UQCRFS1;GNAI3;NDUFS3;NDUFB5 |
PARK2 has several biochemical functions, for example, F-box domain binding, G-protein coupled receptor binding, Hsp70 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARK2 itself. We selected most functions PARK2 had, and list some proteins which have the same functions with PARK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| F-box domain binding | |
| G-protein coupled receptor binding | GNA13B;SFTPB;NPFF;PROK2;GNA11B;FCN1;SFTPBB;GNA14;PICK1 |
| Hsp70 protein binding | C11orf73;RPS3;RNF207;STUB1;FAM119A;DNAJB2;PARK2;MVD;CDK1 |
| PDZ domain binding | CCDC88C;SNTB1;GRIK5;GRIA1;USHBP1;ATP2B3A;ATP2B1B;PSEN1;ERC1 |
| SH3 domain binding | OSTF1;PTTG2;FUT8;QKI;PDCD6IP;ADAM19;RAD9A;USP8;GPX1 |
| actin binding | MYOT;INPPL1A;SHANK3;MYPN;SPTBN1;SYNE1;ABLIM2;CAP2;PARVG |
| beta-catenin binding | PROP1;SHROOM2;GSK3B;PSEN1;BTRC;TCF7L1A;CTNNA3;TBL1XR1;HDAC6 |
| chaperone binding | AHSA2;ATP1A1;DNAJB1;BAG1;DLST;HYOU1;TBCA;TIMM44;PFDN4 |
| cullin family protein binding | DCUN1D2A;DCUN1D5;ANAPC11;CCDC22;TCHP;DCUN1D2;KCTD17;DCUN1D4;RBX1 |
| enzyme binding | ATF7;HYAL2;AXIN1;MARCH6;NR5A1;VAPB;DNM2;HIST1H2AL;ARRB2 |
| heat shock protein binding | TPR;PACRG;EEF1D;DMPK;DNAJA3B;PPID;GM5506;PPP5C;FKBP5 |
| histone deacetylase binding | BRMS1L;PKN1;RBBP4;SUDS3;KAT2A;DHX36;HDAC5;ANKRA2;MAGEA2B |
| identical protein binding | KCNH2;NCL;CD247;PKD2L1;NOL3;ACTG1;HOOK3;LTBR;PTEN |
| kinase binding | CHP;DLG4;CEBPB;STUB1;BARD1;BTG1;CDC37;EMP2;PTPN22 |
| ligase activity | PCXA;TMEM129;PCXB;BIRC3;MGRN1;RNF180;TOPORS;HECW1;ZNRF1 |
| phospholipase binding | APOC2;CALM2;LMNB1;CALM3;CALM;PDPK1;SNCA;ARHGAP6;NEFL |
| protein binding | Raet1c;XIAP;RFWD2;ICA1L;PRKCQ;Rhox5;VPS11;TRIM55;SNRPE |
| protein kinase binding | RNF138;H2AFY;DLG1;TTN;FAM83A;CACNB2;SPRED1;AGTR1A;TMEM173 |
| tubulin binding | STMN4L;GPAA1;TPR;STMN1A;PARK2;CLIP1;RITA1;EML2;AGTPBP1 |
| ubiquitin binding | OTUB1;OTUB1A;TOP2A;NSFL1C;PER2;USP5;SHRPRBCK1R;UBE2N;FAM125A |
| ubiquitin conjugating enzyme binding | RNF19A;ANKIB1A;DCUN1D1;ARIH1L;UBE2V1;RNF144AB;DCUN1D4;TRAF6;DCUN1D5 |
| ubiquitin protein ligase activity | RABGEF1;FBXL22;MDM2;RBX1;UBE2NA;RNF121;HLTF;CMTM2A;TRIM72 |
| ubiquitin protein ligase activity involved in ERAD pathway | AMFR;TRIM25;TMEM129;SYVN1;PARK2;RNF185;RNF5;STUB1 |
| ubiquitin protein ligase binding | HDAC6;PRKAR2A;CALR;HM13;PRR5L;UBE2J1;ARIH1;RNF40;ANKRD32 |
| ubiquitin-protein transferase activity | MARCH1;PARK2;UBE2D1;ZNRF1;TRIM9;FBXO7;FBXO2;FBXL6;UBA1 |
| ubiquitin-specific protease binding | PARK7;CHMP3;SART3;BAG6;MARCH6;VPS24;SELS;SYVN1;DERL1 |
| zinc ion binding | NPEPPS;MARCH5L;PDLIM5A;UPF1;APOBEC2A;MICALL2B;ADAM5;ADAM23;TAF2 |
PARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARK2.
PINK1; RANBP2
- Q&As
- Reviews
Q&As (5)
Ask a questionBesides Parkinson's disease, PARK2 mutations have been linked to other neurodegenerative disorders, expanding the clinical implications of studying this protein.
Yes, drug development efforts are underway to modulate PARK2 activity and enhance its neuroprotective functions as a potential therapeutic approach for Parkinson's disease.
PARK2 research provides crucial insights into the role of mitochondrial dynamics in neurodegenerative diseases, helping unravel the mechanisms underlying these disorders and paving the way for targeted therapies.
Genetic testing can help identify individuals with PARK2 mutations, allowing for personalized treatment strategies tailored to their specific genetic profile.
PARK2 is implicated in controlling inflammation in the brain, and its dysfunction may contribute to neuroinflammatory processes observed in Parkinson's disease.
Customer Reviews (3)
Write a reviewTheir expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.
Their knowledgeable team is readily available to address any questions or concerns, guaranteeing a smooth experimental process.
the manufacturer of PARK2 protein provides excellent technical support, ensuring prompt assistance and guidance.
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