PDE1A Protein


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Official Full Name PDE1A phosphodiesterase 1A, calmodulin-dependent
Background Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic;nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime;monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent;PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 (PubMed 11342109);;Fidock et al., 2002 (PubMed 11747989)).
Synonyms PDE1A; phosphodiesterase 1A, calmodulin-dependent; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A; hCam-1; cam-PDE 1A; 61 kDa Cam-PDE; phosphodiesterase-1A; calmodulin-dependent phosphodiesterase; 3,5 cyclic nucleotide phosphodiesterase; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; HCAM1; HSPDE1A; MGC26303;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • His
    • His (Fc)-Avi
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE1A-29692TH Recombinant Human PDE1A N/A Inquiry
    Human PDE1A-333H Recombinant Human PDE1A Mammalian Cell His Inquiry
    Human PDE1A-471H Recombinant Human PDE1A, His-tagged, Active Sf9 Insect Cell His Inquiry
    Rhesus Macaque PDE1A-3345R Recombinant Rhesus monkey PDE1A Protein, His-tagged Mammalian Cell His Inquiry
    Human PDE1A-3353HCL Recombinant Human PDE1A 293 Cell Lysate HEK293 N/A Inquiry
    Human PDE1A-1630H Recombinant Human PDE1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Rhesus Macaque PDE1A-3163R Recombinant Rhesus Macaque PDE1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human PDE1A-3814H Recombinant Human PDE1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human PDE1A-779HFL Recombinant Full Length Human PDE1A Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human PDE1A-1787H Recombinant Human PDE1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human PDE1A-300H Recombinant Human PDE1A Protein, His-tagged E.coli His Inquiry
    Mouse Pde1a-4742M Recombinant Mouse Pde1a Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    PDE1A involved in several pathways and played different roles in them. We selected most pathways PDE1A participated on our site, such as Purine metabolism, Calcium signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism NME3; NME1; POLD4; FHIT; HDDC3; PGM1; NME6; POLR3C; DGUOK; GMPR
    Calcium signaling pathway P2RX2; CAMK2A; PPP3CB; PPP3CCA; PLCD3A; CHRM5B; CALM2; SLC8A1B; SLC25A5; ITPR3
    Olfactory transduction PDE1C; OR2F1; OLFR24; OR12D2; OLFR491; OR4C12; PRKACA; OLFR508; OLFR495; OR1L6
    Taste transduction PLCB2; TAS2R3; TAS2R113; GNG13; TAS2R123; TAS1R3; TAS2R117; TAS2R116; GNB3; TRPM5
    Renin secretion CALM1; CLCA3; REN2; REN; PRKACA; PPP3CA; GNAS; AGTR1B; PPP3R1; PDE1A

    PDE1A has several biochemical functions, for example, calmodulin binding, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1A itself. We selected most functions PDE1A had, and list some proteins which have the same functions with PDE1A. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding STRN4; EDF1; MYH1E; ATPIF1; EPB41B; MYLK2; PHKG1; CAMK2A; ATP2B4; MYO1G
    calmodulin-dependent cyclic-nucleotide phosphodiesterase activity PDE1C; PDE1B; PDE1A; USB1; TDP2B
    metal ion binding MPO; ZNF202; ZFP513; JUB; LNPA; POGZA; KIN; MORC2A; CYP2K16; ZNF558

    PDE1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1A.


    Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).
    Santone, R; Giorgi, M; et al. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. JOURNAL OF NEUROSCIENCE RESEARCH 84:1020-1026(2006).

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