pde1a
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  • Official Full Name
  • PDE1A phosphodiesterase 1A, calmodulin-dependent
  • Background
  • Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic;nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime;monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent;PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 (PubMed 11342109);;Fidock et al., 2002 (PubMed 11747989)).
  • Synonyms
  • PDE1A; phosphodiesterase 1A, calmodulin-dependent; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A; hCam-1; cam-PDE 1A; 61 kDa Cam-PDE; phosphodiesterase-1A; calmodulin-dependent phosphodiesterase; 3,5 cyclic nucleotide phosphodiesterase; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; HCAM1; HSPDE1A; MGC26303
Cat.#:PDE1A-300HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDE1A Protein, His-tagged
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Cat.#:PDE1A-29692THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDE1A
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Cat.#:PDE1A-333HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PDE1A
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Cat.#:PDE1A-471HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE1A, His-tagged, Active
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Cat.#:PDE1A-3345RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDE1A Protein, His-tagged
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Cat.#:PDE1A-3353HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDE1A 293 Cell Lysate
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Involved Pathway

PDE1A involved in several pathways and played different roles in them. We selected most pathways PDE1A participated on our site, such as Purine metabolism, Calcium signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
POLR3E; ENTPD5; ADKB; PKLR; AK7; NME1; PNP6; PPAT; GUCY1B3; GUCY2C
Calcium signaling pathway
BDKRB2; CHRM2; ADCY1B; TACR3L; CAMK2A; PLCD4; SLC8A2B; PHKA1; ERBB3; AGTR1A
Olfactory transduction
OLFR491; OLFR154; SLC8A1; OR2C1; OR5H1; OR2B3; GNG7; OR4C13; OLFR482; OR51B4
Taste transduction
GNAT3; TAS2R134; TAS2R144; TAS2R126; TAS2R20; TAS2R40; TAS2R143; TAS2R42; TRPM5; ASIC2
Renin secretion
Ren1; CALML3; PPP3R2; PDE3A; AQP1; CALM2; PTGER2; CLCA3; PPP3CA; LOC100328615
Morphine addiction
GABRA4; GNGT1; GABRP; GABRD; GNG4; GNG8; GNAI1; GNG3; PDE4B; GABRB1

Protein Function

PDE1A has several biochemical functions, for example, calmodulin binding, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1A itself. We selected most functions PDE1A had, and list some proteins which have the same functions with PDE1A. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein KCNN1B; NOS2; GAP43; MARCKSL1A; ADCY3; PPP3CB; MYO5A; MYH10; C2orf62; SMTNL1
Function calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
Related Protein PDE1C; PDE1A; PDE1B; USB1; TDP2B
Function metal ion binding
Related Protein ZNF277; ZFP319; ACLY; SPRTN; HMOX2A; ADAT1; ENPP4; MAT2AB; EXT2; CYP1D1

Interacting Protein

PDE1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1A.
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PDE1A Related Articles

Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).
Santone, R; Giorgi, M; et al. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. JOURNAL OF NEUROSCIENCE RESEARCH 84:1020-1026(2006).