- Human(7)
- Mouse(1)
- Rhesus Macaque(1)
Recombinant Full Length Human PDE1A Protein, C-Flag-tagged
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Cat.No. : | PDE1A-779HFL Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Full Length Human PDE1A Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
Description : | Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+). |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 62.1 kDa |
AA Sequence : | MGSSATEIEE LENTTFKYLT GEQTEKMWQR LKGILRCLVK QLERGDVNVV DLKKNIEYAA SVLEAVYIDE TRRLLDTEDE LSDIQTDSVP SEVRDWLAST FTRKMGMTKK KPEEKPKFRS IVHAVQAGIF VERMYRKTYH MVGLAYPAAV IVTLKDVDKW SFDVFALNEA SGEHSLKFMI YELFTRYDLI NRFKIPVSCL ITFAEALEVG YSKYKNPYHN LIHAADVTQT VHYIMLHTGI MHWLTELEIL AMVFAAAIHD YEHTGTTNNF HIQTRSDVAI LYNDRSVLEN HHVSAAYRLM QEEEMNILIN LSKDDWRDLR NLVIEMVLST DMSGHFQQIK NIRNSLQQPE GIDRAKTMSL ILHAADISHP AKSWKLHYRW TMALMEEFFL QGDKEAELGL PFSPLCDRKS TMVAQSQIGF IDFIVEPTFS LLTDSTEKIV IPLIEEASKA ETSSYVASSS TTIVGLHIAD ALRRSNTKGS MSDGSYSPDY SLAAVDLKSF KNNLVDIIQQ NKERWKELAA QGESDLHKNS EDLVNAEEKH DETHSTRTRP LEQKLISEED LAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction |
Figure : |
![]() Coomassie blue staining of purified PDE1A protein. |
Gene Name : | PDE1A phosphodiesterase 1A [ Homo sapiens (human) ] |
Official Symbol : | PDE1A |
Synonyms : | HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A |
Gene ID : | 5136 |
mRNA Refseq : | NM_005019.7 |
Protein Refseq : | NP_005010.2 |
MIM : | 171890 |
UniProt ID : | P54750 |
◆ Recombinant Protein
Pde1a-4742M | Recombinant Mouse Pde1a Protein, Myc/DDK-tagged | +Inquiry |
PDE1A-300H | Recombinant Human PDE1A Protein, His-tagged | +Inquiry |
PDE1A-333H | Recombinant Human PDE1A | +Inquiry |
PDE1A-3345R | Recombinant Rhesus monkey PDE1A Protein, His-tagged | +Inquiry |
PDE1A-29692TH | Recombinant Human PDE1A | +Inquiry |
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◆ Lysates
PDE1A-3353HCL | Recombinant Human PDE1A 293 Cell Lysate | +Inquiry |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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