Recombinant Human PDE1A

• Cat.No.: PDE1A-29692TH
• Product Overview: Recombinant full length protein (Human): PDE1A ,with an N terminal enzyme tag. MW= 88.3 kDa.Expressed in a Baculovirus infected Sf9 cell expression system.

Specification

• Description: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al.
• Tissue specificity: Several tissues, including brain, kidney, testes and heart.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 20mM Glutathione, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Gene Information

• Gene Name: PDE1A phosphodiesterase 1A, calmodulin-dependent [ Homo sapiens ]
• Official Symbol: PDE1A
• Synonyms: PDE1A; phosphodiesterase 1A, calmodulin-dependent; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A
• Gene ID: 5136
• mRNA Refseq: NM_001003683
• Protein Refseq: NP_001003683
• MIM: 171890
• Uniprot ID: P54750
• Chromosome Location: 2q32.1
• Pathway: Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Calmodulin induced events, organism-specific biosystem
• Function: calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity