Recombinant Human PDE1A

Cat.No. : PDE1A-29692TH
Product Overview : Recombinant full length protein (Human): PDE1A ,with an N terminal enzyme tag. MW= 88.3 kDa.Expressed in a Baculovirus infected Sf9 cell expression system.
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Description : Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al.
Tissue specificity : Several tissues, including brain, kidney, testes and heart.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 20mM Glutathione, 100mM Sodium chloride, pH 8.0
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Gene Name : PDE1A phosphodiesterase 1A, calmodulin-dependent [ Homo sapiens ]
Official Symbol : PDE1A
Synonyms : PDE1A; phosphodiesterase 1A, calmodulin-dependent; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A;
Gene ID : 5136
mRNA Refseq : NM_001003683
Protein Refseq : NP_001003683
MIM : 171890
Uniprot ID : P54750
Chromosome Location : 2q32.1
Pathway : Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Calmodulin induced events, organism-specific biosystem;
Function : calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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