PF4
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Official Full Name
platelet factor 4
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Overview
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012] -
Synonyms
PF4; platelet factor 4; PF-4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Horse
- Human
- Mouse
- Pig
- Rabbit
- Rat
- E.coli
- HEK293
- HEK293T
- Human
- Human Cells
- Human Platelet
- Mammalian Cell
- Mammalian cells
- Yeast
- Biotin
- Flag
- GST
- His
- Fc
- Avi
- SUMO
- mFc
- Myc
- DDK
- N
- C
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PF4 involved in several pathways and played different roles in them. We selected most pathways PF4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL1R2;IL12RB1;CD27;Cxcl15;XCL2;IL28RA;CTF1;IL15;GM1987 |
| Chemokine signaling pathway | GRK4;GM2506;ARRB1;CXCL16;CCR10;XCL2;PIK3CG;CCL18;CCL25 |
PF4 has several biochemical functions, for example, CXCR3 chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PF4 itself. We selected most functions PF4 had, and list some proteins which have the same functions with PF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CXCR3 chemokine receptor binding | CXCL11.8;CXCL11;PF4;CXCL13;CXCL9;CXCL10 |
| chemokine activity | CCL38.1;CCL19A.2;Ccl21a;CXCL8B.3;CCL18;CCL23;CX3CL1;CCL17;CXCL19 |
| heparin binding | APPB;COMP;KNG1;ADAMTSL5;SMOC2;FGF1;RSPO1;FN1;AZU1 |
PF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PF4.
PLEK; a41_vaccw
Research Area
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Customer Reviews (3)
Write a reviewthe PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.
Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.
he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.
Q&As (5)
Ask a questionSome research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.
PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.
Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.
Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.
ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.
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