PF4

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PF4

Official Full Name platelet factor 4
Background This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]
Synonyms PF4; platelet factor 4; PF-4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cells
    • Human Platelet
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • DYKDDDDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PF4-151H Recombinant Human PF4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human PF4-150H Recombinant Human PF4 Protein, His-tagged E.coli His
    Human PF4-1654H Recombinant Human PF4, GST-tagged E.coli GST
    Human PF4-194H Recombinant Human Platelet Factor 4 Human N/A
    Human PF4-253H Native Human Platelet Factor 4 Human Platelet N/A
    Human PF4-267H Recombinant Human PF4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human PF4-3283HCL Recombinant Human PF4 293 Cell Lysate HEK293 N/A
    Human PF4-52H Human Platelet Factor 4 Human Platelet N/A
    Human PF4-590H Recombinant Human platelet factor 4, His-tagged E.coli His
    Human PF4-71H Human Platelet Factor 4(Purified) Reference standard N/A
    Human PF4-87H Recombinant Human PF4 protein E.coli N/A
    Mouse Pf4-151M Recombinant Mouse Pf4 Protein, His-tagged E.coli His
    Mouse Pf4-152M Recombinant Mouse Platelet Factor 4 E.coli N/A
    Mouse Pf4-159M Recombinant Mouse Pf4 Protein, His-tagged E.coli His
    Mouse Pf4-4802M Recombinant Mouse Pf4 Protein E. coli
    Mouse Pf4-4803M Recombinant Mouse Pf4 Protein E. coli
    Mouse Pf4-4804M Recombinant Mouse Pf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Pf4-611M Recombinant Mouse Pf4 protein E.coli N/A
    Rat Pf4-153R Recombinant Rat Pf4 Protein, His-tagged E.coli His
    Rat Pf4-154R Recombinant Rat Pf4 Protein, His/GST-tagged E.coli His/GST
    Rat PF4-4388R Recombinant Rat PF4 Protein Mammalian Cell His
    Bovine PF4-901B Recombinant Bovine PF4 protein E.coli N/A

    PF4 involved in several pathways and played different roles in them. We selected most pathways PF4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL8L2; BMP7B; INHBC; TNFSF14; CCL4L2; IL22RA1; CCR6; VEGFB; CX3CL1; CCL19
    Chemokine signaling pathway PIK3R3; WASL; CCL3L1; GNAI3; CDC42; CCL5; HCK; Ccl27a; ADRBK1; CXCL11

    PF4 has several biochemical functions, for example, CXCR3 chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PF4 itself. We selected most functions PF4 had, and list some proteins which have the same functions with PF4. You can find most of the proteins on our site.

    Function Related Protein
    CXCR3 chemokine receptor binding CXCL13; CXCL9; PF4; CXCL11.8; CXCL11; CXCL10
    chemokine activity CCL19B; CCL20A.3; CCL6; CXCL19; CCL25; CCL38A.5; CCL3; CXCL13; PPBP; CXCL1
    heparin binding ANG; CCL5; CXCL6; VEGFAB; PDCD5; WISP3; FMODA; SLIT1B; WISP1B; ABP1

    PF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PF4.

    PLEK; a41_vaccw

    Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
    Matsuo, T; Motohashi, S; et al. Production of Anti-platelet Factor 4/Heparin Complex Antibodies After Cardiovascular Surgery. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:177-180(2015).

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