PF4

  • Official Full Name

    platelet factor 4

  • Overview

    This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]
  • Synonyms

    PF4; platelet factor 4; PF-4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Horse
  • Human
  • Mouse
  • Rabbit
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cells
  • Human Platelet
  • Mammalian Cell
  • Mammalian cells
  • Biotin
  • C
  • His
  • Myc
  • DDK
  • DYKDDDDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PF4-194H Active Recombinant Human Platelet Factor 4 Human N/A
Human PF4-52H Human Platelet Factor 4 Human Platelet N/A
Human PF4-590H Recombinant Human platelet factor 4, His-tagged E.coli His
Human PF4-1654H Recombinant Human PF4, GST-tagged E.coli GST
Human PF4-150H Recombinant Human PF4 Protein, His-tagged E.coli His
Human PF4-87H Recombinant Human PF4 protein E.coli N/A
Human PF4-3283HCL Recombinant Human PF4 293 Cell Lysate HEK293 N/A
Human PF4-151H Recombinant Human PF4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human PF4-253H Native Human Platelet Factor 4 Human Platelet N/A
Human PF4-71H Human Platelet Factor 4(Purified) Reference standard N/A
Human PF4-659HFL Active Recombinant Full Length Human PF4 Protein, C-Flag-tagged Mammalian cells Flag
Human PF4-2136H Recombinant Human PF4 Protein (Glu32-Ser101), C-His tagged Mammalian cells C-His
Human PF4-267H Recombinant Human PF4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PF4-245H Active Recombinant Human PF4 Protein (Glu32-Ser101), N-His tagged, Animal-free, Carrier-free E.coli N-His
Human PF4-061P Active Recombinant Human PF4 Protein (70 aa) E.coli
Human PF4-2137H Recombinant Human PF4 Protein (Glu32-Ser101) E.coli Tag Free
Human PF4-1650H-B Recombinant Human PF4 Protein Pre-coupled Magnetic Beads HEK293
Human PF4-04H Recombinant Human PF4 Protein E.coli
Human PF4-4866H Recombinant Human PF4 Protein (Glu32-Ser101), N-GST tagged E.coli N-GST
Human PF4-15H Recombinant Human PF4 Protein, Biotin-tagged E.coli Biotin
Human PF4-166P Active Recombinant Human PF4 Protein HEK293
Human PF4-1650H Recombinant Human PF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pf4-152M Recombinant Mouse Platelet Factor 4 E.coli N/A
Mouse Pf4-151M Recombinant Mouse Pf4 Protein, His-tagged E.coli His
Mouse Pf4-611M Recombinant Mouse Pf4 protein E.coli N/A
Mouse Pf4-159M Recombinant Mouse Pf4 Protein, His-tagged E.coli His
Mouse Pf4-4802M Active Recombinant Mouse Pf4 Protein E. coli
Mouse Pf4-3331M Recombinant Mouse Pf4 protein, His-SUMO-tagged E.coli His-SUMO
Mouse Pf4-4803M Active Recombinant Mouse Pf4 Protein E. coli
Mouse Pf4-31M Recombinant Mouse Pf4 Protein E.coli
Mouse Pf4-4804M Recombinant Mouse Pf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pf4-37M Recombinant Mouse Pf4 Protein, Biotin-tagged E.coli Biotin
Rat Pf4-153R Recombinant Rat Pf4 Protein, His-tagged E.coli His
Rat PF4-4388R Recombinant Rat PF4 Protein Mammalian Cell His
Rat Pf4-154R Recombinant Rat Pf4 Protein, His/GST-tagged E.coli His/GST
Rat PF4-4048R-B Recombinant Rat PF4 Protein Pre-coupled Magnetic Beads HEK293
Rat PF4-4048R Recombinant Rat PF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit PF4-2400R Recombinant Rabbit PF4 Protein, His-tagged E.coli N-His
Bovine PF4-901B Recombinant Bovine PF4 protein E.coli N/A
Cattle PF4-1180C Recombinant Cattle PF4 Protein, His-tagged E.coli N-His
Horse PF4-1181H Recombinant Horse PF4 Protein, His-tagged E.coli N-His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PF4 Related Articles
  • PF4 Related Research Area

PF4 involved in several pathways and played different roles in them. We selected most pathways PF4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL8L2;IL28RA;GHRA;CCL5;FLT1;TGFBR1B;CCL1;CSF3;IL11
Chemokine signaling pathwayRASGRP2;CCR7;KRAS;PXN;RAC2;CCL4L1;JAK3;GNAI3;GRK4

PF4 has several biochemical functions, for example, CXCR3 chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PF4 itself. We selected most functions PF4 had, and list some proteins which have the same functions with PF4. You can find most of the proteins on our site.

Function Related Protein
CXCR3 chemokine receptor bindingCXCL10;PF4;CXCL13;CXCL11;CXCL11.8;CXCL9
chemokine activityXCL2;CXCL13;CXCL2;CCL14;CXCL14;CCL8;CXCL18B;CCL28;CCL39.1
heparin bindingWISP1B;SELP;SERPINE2;APLP1;PTCH1;NAV2;UBE4A;Epy;APP

PF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PF4.

PLEK; a41_vaccw

Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
Matsuo, T; Motohashi, S; et al. Production of Anti-platelet Factor 4/Heparin Complex Antibodies After Cardiovascular Surgery. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:177-180(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any therapeutic approaches targeting PF4 protein? 02/17/2023

Some research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.

How does PF4 protein contribute to the pathogenesis of inflammation? 11/11/2022

PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.

What are the potential treatment options for patients with HIT? 04/24/2017

Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.

Can PF4 protein be used as a biomarker for other conditions? 06/20/2016

Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.

What diagnostic methods are used to assess PF4 protein levels? 01/30/2016

ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.

Customer Reviews (3)

Write a review
Reviews
09/07/2022

    the PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

    06/30/2018

      Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.

      12/12/2017

        he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

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