Recombinant Human PF4, GST-tagged

• Cat.No.: PF4-1654H
• Product Overview: Recombinant Human PF4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-101aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: PF4 platelet factor 4 [ Homo sapiens ]
• Official Symbol: PF4
• Synonyms: PF4; platelet factor 4; chemokine (C X C motif) ligand 4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; PF-4; MGC138298
• Gene ID: 5196
• mRNA Refseq: NM_002619
• Protein Refseq: NP_002610
• MIM: 173460
• UniProt ID: P02776
• Chromosome Location: 4q12-q21
• Pathway: CXCR3-mediated signaling events, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem
• Function: chemokine activity; heparin binding

Reviews

09/07/2022

the PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

06/30/2018

Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.

12/12/2017

he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

Q&As

Are there any therapeutic approaches targeting PF4 protein?

Some research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.

How does PF4 protein contribute to the pathogenesis of inflammation?

PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.

What are the potential treatment options for patients with HIT?

Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.

Can PF4 protein be used as a biomarker for other conditions?

Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.

What diagnostic methods are used to assess PF4 protein levels?

ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.