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Active Recombinant Human PIK3R1/PIK3CD protein, His-tagged

Cat.No. : PIK3R1&PIK3CD-157H
Product Overview : Recombinant full-length human p110 delta and human p85 alpha were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.
  • Specification
  • Gene Information
  • Related Products
Description : PI3K (p110 delta/p85 alpha) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. PI3K (p110 delta/p85 alpha) plays a role in oncogenic transformation, and is consistently expressed at a high level in blast cells from AML. PI3K (p110 delta/p85 alpha) can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that lead to neutrophil polarization, and regulates directional migration, but not random locomotion. PI3K (p110 delta/p85 alpha) signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.
Source : Insect cells
Species : Human
Tag : His
Form : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Bio-activity : 2200 nmol/min/mg
Molecular Mass : p110 delta~111 kDa and p85 alpha~86 kDa
Purity : >90%
Applications : Kinase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ]
Official Symbol : PIK3R1
Synonyms : PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); p85-ALPHA;
Gene ID : 5295
mRNA Refseq : NM_181523
Protein Refseq : NP_852664
MIM : 171833
UniProt ID : P27986
Chromosome Location : 5q13.1
Pathway : 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem;
Function : 1-phosphatidylinositol binding; ErbB-3 class receptor binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatidylinositol 3-kinase regulator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein phosphatase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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