PKM
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Official Full Name
pyruvate kinase, muscle
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Overview
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] Pyruvate kinase, a glycolytic enzyme, catalyses the conversion of phosphoenolpyruvate to pyruvate. In mammals, the M1 isoform (PKM1) is expressed in most adult tissues. The M2 isoform (PKM2), an alternatively-spliced variant of M1, is expressed during emb -
Synonyms
PKM; pyruvate kinase, muscle; PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; pyruvate kinase PKM; p58; OIP-3; tumor M2-PK; PK, muscle type; pyruvate kinase 2/3; OPA-interacting protein 3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; thyroid hormone-binding protein 1; epididymis secretory protein Li 30; cytosolic thyroid hormone-binding protein; thyroid hormone-binding protein, cytosolic; cytosolic thyroid;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Chinese hamster
- Hamster
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Protein Conjugation
- Flag
- His
- His (Fc)
- Avi
- Myc
- GST
- His|GST
- His|T7
- DDK
- Myc|DDK
- N/A
- N
- 6×His
- Involved Pathway
- Protein Function
- Interacting Protein
- PKM Related Articles
PKM involved in several pathways and played different roles in them. We selected most pathways PKM participated on our site, such as Glycolysis / Gluconeogenesis, Purine metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | PGM1;MINPP1A;ALDOB;GPIA;GPIB;MINPP1B;ACSS2;BPGM;HK3 |
| Purine metabolism | AK3;ENTPD2A.1;NT5M;ADKB;ADSL;PDE4D;NT5C2A;NUDT5;PRIM1 |
| Pyruvate metabolism | ACAT1;ackA;DLAT;PDK3B;ME1;GRHPRA;LDHB;ACACA;MDH1 |
| Metabolic pathways | ENPP3;FUT2;MTHFD2L;UCK2A;PDXKA;LASS4;COX4I1;RABGNT1;ALG8 |
| Carbon metabolism | MTHFR;ANI_1_2390104;GPI1;PFKP;SHMT1;SHMT2;ACSS2L;SDHDB;PHGDH |
| Biosynthesis of amino acids | TKTB;MAT2AL;CTH;GOT1;PKMA;PYCRL;PRPS1;PCXB;PFKM |
| Type II diabetes mellitus | TNF;INS-IGF2;PIK3R3;SOCS4;INS;PIK3CG;MAPK10;INS1;IRS2 |
| Viral carcinogenesis | HIST2H4;TP53;SNW1;SRF;HIST1H4I;HIST1H2BI;PKM2;HIST1H4M;HDAC7A |
| Central carbon metabolism in cancer | PDGFRB;ERBB2;TRP53;PIK3R2;HRAS;PFKL;PDHA2;PKM2;SIRT3 |
PKM has several biochemical functions, for example, ADP binding, ATP binding, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKM itself. We selected most functions PKM had, and list some proteins which have the same functions with PKM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | LONP1;GLUD1;P2RY1;PKM;MYO3A;VCP;PRPS2;MYO9B;ATP1A1 |
| ATP binding | CAMK1G;KATNAL2;RLN1;OASL;HIPK1;ADCK1;GRK1A;TEX14;ATAD2B |
| MHC class II protein complex binding | CD74;HLA-DMB;ANXA11;MS4A1;ATP1B1;PKM2;HLA-DOB;YWHAE;HLA-DMA |
| catalytic activity | ACSL4B;LANCL3;PPTC7A;MED16;GPT2L;PPM1LB;TGM3;RAG1;PKMB |
| kinase activity | MAPKAPK2B;MARCKSA;PKN1B;PINK1;PRKG1A;CKBB;MOB1BA;CKBA;ADCK3 |
| magnesium ion binding | PCK1;FARS2;AASDHPPT;SERPINB1A;PAPOLA;RPS6KA5;CIB3;STK38L;PPM1N |
| metal ion binding | EYA4;ANGPT2;SRSF7A;FOXP3;PDP2;COPS5;MAP2K5;CALUB;ZFP1 |
| nucleotide binding | MAPK14B;ARL3L2;ATP2B1B;HNRNPH3;GNAI2B;RASEF;ACVR2AA;NXF3;DHX36 |
| poly(A) RNA binding | C1orf35;MYH9;SNRNP40;AATF;PTRF;MRPL14;RPL10L;DDX28;MDH2 |
| potassium ion binding | PKLR;PKMA;PDXK;KCNA4;PKM2;SLC24A2;SLC24A5;HDAC4;PKM |
| protein binding | TFG;ATP5F1;TAGLN2;PTGIS;UACA;FAM134C;TDGF1;CX3CR1;NGB |
| pyruvate kinase activity | PKLR;PKM2;PKMB;PKM;PKMA |
| transferase activity | VPRBP;GSTAL;CKMT2B;GYG1B;TOMT;MGAT1B;SAT2B;CDYL;NMRK2 |
PKM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKM here. Most of them are supplied by our site. Hope this information will be useful for your research of PKM.
Pou5f1; PRNP; polg_hcvbk; Casp3; Casp7; Invs; BRINP1; FGG; UBL4A
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