PLCG1
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Official Full Name
Phospholipase C, gamma 1 -
Overview
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. -
Synonyms
Phospholipase C, gamma 1;PLCG1;NCKAP3;PLC-II;PLC1;PLC148;PLCgamma1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- HEK293
- Wheat Germ
- E.coli
- Mammalian Cells
- DDK
- Myc
- Non
- His
- Avi
- Fc
- Flag
- GST
Involved Pathway
PLCG1 involved in several pathways and played different roles in them. We selected most pathways PLCG1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-small cell lung cancer | MAP2K2,ERBB2,FHIT,SOS1,TGFA,AKT2,GRB2,PDPK1,STK4,RXRA |
| Metabolic pathways | CMPK1,GMPPAA,MTHFD2,GPAT2,ACSM3,CYP2C54,SMS,PTGES3B,PRPS1A,DHRS13L1 |
| Inflammatory mediator regulation of TRP channels | CYP2C70,CYP2J2,HRH1,ALOX12,MAP2K6,PRKCA,CAMK2G,TRPV4,CALM2,CALML3 |
| Neurotrophin signaling pathway | RAC1,PLCG2,NTRK3,RPS6KA3,IRAK4,RPS6KA1,MAP2K7,RAF1,CALML5,CAMK4 |
| NF-kappa B signaling pathway | CD40,NFKB2,TRAF3,PTGS2,TICAM2,BIRC2,GM10591,MYD88,TNFRSF13C,CARD11 |
| Inositol phosphate metabolism | INPP5K,PIP4K2AA,PTENA,PIP5K1AA,MINPP1A,PIK3C3,MTMR7B,PIK3CD,PLCE1,NUDT4A |
| Natural killer cell mediated cytotoxicity | IFNA2,TNFRSF10D,SH2D1B,IFNA5,ITGAL,KIR2DS3,HLA-G,NFATC1,Raet1a,IFNA8 |
| Pathways in cancer | ITGA2B,WNT16,MSH3,BIRC3,CDC42,IKBKG,PRKACA,FOS,GNAS,FGFR3 |
| Rap signaling pathway | TLN1,FGF2,SIPA1L1,PDGFRB,PDGFA,CALM1,FARP2,RAF1,PIK3R3,RALB |
Protein Function
PLCG1 has several biochemical functions, for example, calcium ion binding,glutamate receptor binding,neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCG1 itself. We selected most functions PLCG1 had, and list some proteins which have the same functions with PLCG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | TP53,PPP1R12B,STAT3,MSH2,TNNI3,CASP9,STK11IP,PRC1,AP2A2,ZC3HC1 |
| receptor tyrosine kinase binding | GNB2L1,DNAJA3,HYAL2,PTPN2,PTPN11,NRG1,TRP53,ANGPT1,ANGPT4,ARHGEF16 |
| protein binding | PCDHA4,GPATCH8,FAM168A,MC4R,ISCU,BAP1,UBA7,NMUR2,ZBTB1,SERPINB9 |
| phospholipase C activity | PLCB2,PLCL1,ADORA1,PLCG2,PDIA3,PLCB4,PLCB3,PLCH2,PLCE1 |
| glutamate receptor binding | SYNDIG1,CAMK2A,GRIN2A,GRIN1 |
| phosphatidylinositol phospholipase C activity | CCKBR,BDKRB2,CCL5,PLCD1A,PLCB3,PLCG2,PLCL2,CASR,CHRM1,PLCD3 |
| neurotrophin TRKA receptor binding | FRS2,SHC1,NGFR,GRB2,PIK3R1,EFNA5 |
| calcium ion binding | NCS1,PCDH2AB1,THBS2,PCDHGB1,MAN1B1,SLIT2,CALB2,NKD2,LETM1,CALM |
| receptor signaling protein activity | IL1RL1,DOK5,ADRB1,Siglece,CD19,IL4R,RGS14,BAG1,SMAD1,TRAIP |
Interacting Protein
PLCG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCG1.
EGFR;INSR;FGFR1
PLCG1 Related Signal Pathway
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