PLCG1
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Official Full Name
Phospholipase C, gamma 1
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Overview
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. -
Synonyms
Phospholipase C, gamma 1; PLCG1; NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PLCG1 Related Signal Pathway
PLCG1 involved in several pathways and played different roles in them. We selected most pathways PLCG1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PIP5K1C;TPI1;MTMR1;PIP5K2;PI4K2B;PIK3C2A;ITPKA;PIP5K1BA;NUDT4A |
| Metabolic pathways | GUK1;OLAH;PPT2;COX7C;PDHA2;LIAS;KL;GGT6;SDHDA |
| ErbB signaling pathway | STAT5A;MAP2K7;MAP2K2B;NCK2;MAPK8A;GSK3AA;AKT3A;PAK1;PIK3CB |
| Ras signaling pathway | MAPK9;FGF11;FGF21;BRAP;BAD;STK4;FGF7;RELA;CALM4 |
| Rap signaling pathway | RAC2;ACTB;RHOA;PGF;PRKD1;ITGB3;GNAI3;CALM2;FGFR1 |
| Calcium signaling pathway | RYR1B;PRKCBB;GRM5;TRHR2;SLC8A1;PDGFRA;LTB4R2;TACR3A;SLC8A4A |
| NF-kappa B signaling pathway | BCL2A1;CCL4L1;Bcl2a1b;CCL19;NFKBIA;TNFAIP3;TRAF6;TRADD;CD14 |
| HIF- signaling pathway | ERBB2;PDHA1;IGF1R;TCEB1;CAMK2B;IL6R;TLR4;PFKL;PIK3R1 |
| Phosphatidylinositol signaling system | INPP5K;PIK3CD;IPMKB;SYNJ2;MTMR1B;PIP5K1BA;CALM3;PIP5K1C;PLCD1B |
| Phospholipase D signaling pathway | SHC2;Pdgfa&Pdgfb;PLD2;PRKCA;IL-8;KRAS;PDGFRA;SPHK1;PIK3R1 |
| VEGF signaling pathway | PLA2G4F;PTGS2A;RAF1A;RAC1B;BADB;PPP3CB;BAD;RAC3A;MAPK1 |
| Natural killer cell mediated cytotoxicity | PAK1;IFNA5;ITGB2L;MAP2K1;SYK;PIK3R5;KLRA8;ULBP3;PIK3CD |
| T cell receptor signaling pathway | VAV2;PAK7;LCP2;SOS1;CD40LG;NFATC3;SLA1;NFATC2;KRAS |
| Fc epsilon RI signaling pathway | RAC3;PLA2G4C;MAPK1;IL4;RAC1;GM-CSF;FYN;AKT1;GRB2 |
| Fc gamma R-mediated phagocytosis | FCGR2A;ARF6;SPHK1;RAC2;VAV2;GAB2;RPS6KB2;WASF1;CFL2 |
| Leukocyte transendothelial migration | RAC1;CLDN4;CDH5;NOX3;CDC42;CLDN11;OCLN;ACTN1;MYL9 |
| Neurotrophin signaling pathway | FASLG;BAD;PLCG2;MAP2K1;NTF4;MAPK11;CALM4;IRS1;SORT1 |
| Inflammatory mediator regulation of TRP channels | SRC;ACCN3;CAMK2D;PPP1CB;CALM4;PRKCE;CAMK2A;TRPV3;GNAQ |
| Thyroid hormone signaling pathway | PLCZ1;RCAN2;ATP1B2;MED4;STAT1;EP300;GATA4;NOTCH4;CCND1 |
| Vibrio cholerae infection | ATP6V0D2;ATP6V1H;ERO1L;KDELR1;KDELR2;GNAS;ATP6V1C1;ATP6AP1;ATP6V0D1 |
| Epithelial cell signaling in Helicobacter pylori infection | ADAM17;ATP6V1C1;ATP6V1F;MAP2K4;CXCR2;CXCR1;MAPK9;JAM3;MAPK8 |
| Epstein-Barr virus infection | PSMC2;IRAK1;CD19;POLR3D;CSNK2A2;HLA-DRB1;PIK3R3;PSMD7;PSMD2 |
| Pathways in cancer | CCDC6;SKP2;WNT10B;BDKRB1;Kitl;PTK2;KITLG;TGFB2;STAT5A |
| Proteoglycans in cancer | ITGB3;PRKACA;CBLB;MAPK12;FZD5;BRAF;IGF1R;PRKCA;NRAS |
| MicroRNAs in cancer | CD44;PDCD4;ZEB2;RDX;DICER1;FZD3;ABCB1;HDAC4;TRP63 |
| Glioma | PLCG1;NRAS;PIK3CG;CAMK2G;AKT2;CALM1;MDM2;PRKCG;ARAF |
| Non-small cell lung cancer | PIK3R2;FHIT;RASSF5;RASSF1;AKT2;MAP2K1;PIK3CB;MAP2K2;BAD |
| Choline metabolism in cancer | PIP5K1C;DGKG;WASF3;EIF4EBP1;PPAP2A;PLA2G4B;FOS;PDGFA;MAPK9 |
PLCG1 has several biochemical functions, for example, calcium ion binding, glutamate receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCG1 itself. We selected most functions PLCG1 had, and list some proteins which have the same functions with PLCG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CAPNS1A;ANXA9;SLC25A23B;PCLO;NOTCH3;FSTL1A;PCDHA5;CDHR1A;DGKG |
| glutamate receptor binding | GRIN1;PLCG1;CAMK2A;SYNDIG1;GRIN2A |
| neurotrophin TRKA receptor binding | GRB2;NGFR;PLCG1;FRS2;EFNA5;PIK3R1;SHC1 |
| phosphatidylinositol phospholipase C activity | PLD4;PLCH2;CHRM3;PLCD1A;CASR;C3AR1;PLCE1;PLCD3A;PLCB2 |
| phospholipase C activity | PLCB2;PLCB4;PLCE1;PLCG2;ADORA1;PLCG1;PLCL1;PDIA3;PLCB3 |
| protein binding | TYRP1;PRLHR;STXBP2;LSM3;SGTB;CRADD;HCST;CHRAC1;FIBPB |
| protein kinase binding | AP1B1;ELP2;LIMS1;PTPN1;CD4;FBXW5;TBL2;LAT;FAM83B |
| receptor signaling protein activity | SMAD1;ADCYAP1;FLRT2;DOK1;PDCL;CD19;IL4R;BAG1;KLK1B3 |
| receptor tyrosine kinase binding | ZNF259;TOB1;GAS6;PTPN11;PTPN1;TRP53;ZFP259;DNAJA3;ANXA5 |
PLCG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCG1.
EGFR; INSR; FGFR1
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