PLCG2
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Official Full Name
phospholipase C, gamma 2 (phosphatidylinositol-specific)
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Overview
Phospholipase C (PLC) is a class of enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Thirteen kinds of mammalian phospholipase C are classified into six isotypes (β, γ, δ, ε, ζ, η) according to structure. -
Synonyms
PLC-gamma2; PLC; Phospholipase C; PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PLCG2 Related Articles
- PLCG2 Related Signal Pathway
PLCG2 involved in several pathways and played different roles in them. We selected most pathways PLCG2 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLCG2;MTMR8;PLCE1;PLCB2;INPP5A;ITPKB;MIOX;PLCD1;IP6K3 |
| Metabolic pathways | POLR3GLB;MAOB;PYGB;DEGS1;BCO1L;ATP5J;POLR2GL;COX7B;INPP4B |
| ErbB signaling pathway | NCK2B;HBEGFB;MTOR;AKT2;RAF1B;NRG2B;PAK1;PAK2;MAP2K7 |
| Ras signaling pathway | RRAS;FGF3;Fgf15;RELA;MAPK8;ARF6;FGF8;FGF17;NRAS |
| Calcium signaling pathway | HTR6;GRIN1A;ITPR1;EDNRBA;HTR2CL1;ATP2A2;ORAI3;CCKAR;ADORA2A |
| NF-kappa B signaling pathway | NFKBIA;UBE2I;GM10591;PIAS4;CXCL12;CCL13;TAB2;TRADD;ZAP70 |
| HIF- signaling pathway | NOX1;CAMK2A;TCEB1;SERPINE1;MAP2K2;TFRC;HK3;TIMP1;LTBR |
| Phosphatidylinositol signaling system | PIP5K2;PIP4K2B;DGKE;CDS1;INPPL1;PLCG2;CALM3B;PLCD3;PIK3R3 |
| Phospholipase D signaling pathway | SHC3;PLCB2;PIP5K1A;FCER1G;AKT1;RAF1;CXCR1;CYTH4;IL-8 |
| VEGF signaling pathway | PRKCA;PIK3CA;MAPKAPK2A;AKT2;MAPK11;PPP3CCB;PIK3R1;CASP9;MAPK12A |
| Osteoclast differentiation | MAPK1;RELB;AKT1;NCF2;IL1A;NOX3;SFPI1;IFNG;TGFBR2 |
| Platelet activation | P2RX1;ROCK2;COL27A1;APBB1IP;GNAI1;PRKG1;PLA2G4F;PPP1CC;PPP1R12A |
| Natural killer cell mediated cytotoxicity | IFNGR1;TNFRSF10A;TNFSF10;KIR2DL4;TNFRSF10C;KIR2DS4;NFATC2;KIR2DL3;PRKCG |
| B cell receptor signaling pathway | VAV1;MAP2K1;FCGR2B;RAC3;MAPK4;DOK1;BCL10;GSK3AB;TTC6 |
| Fc epsilon RI signaling pathway | PLA2G4F;MAP2K2;PIK3CG;LYN;BTK;PLA2G4D;MAPK9;PIK3R1;KRAS |
| Fc gamma R-mediated phagocytosis | PTPRC;CDC42;VASP;PIK3CB;ARPC1A;PRKCG;WASF3;VAV2;ARF6 |
| Leukocyte transendothelial migration | RASSF5;CD99;PIK3R2;PRKCG;CLDN6;PTK2;PLCG2;CLDN11;VAV1 |
| Neurotrophin signaling pathway | SHC4;BAD;MAPK13;PIK3CB;MAPK12;MAPK8;NTRK1;MAP3K1;KRAS |
| Inflammatory mediator regulation of TRP channels | PPP1CB;PIK3R2;CYP2J6;ITPR3;NGF;ALOX12E;PRKCB;MAPK12;PIK3R3 |
| Thyroid hormone signaling pathway | PLCB2;PLCG2;TP53;THRB;WNT4;HIF1A;PDPK1;PLCB1;MED17 |
| Vibrio cholerae infection | ATP6V1C2;ATP6V1D;ATP6V0B;KDELR1;ATP6V0A1;ATP6V1E1;KDELR3;ATP6V1A;PRKACG |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0D2;CCL5;CXCR1;RELA;ATP6V0A4;IKBKG;MAPK8;TJP1;TCIRG1 |
| Epstein-Barr virus infection | HLA-G;MAPK9;EIF2AK3;MAP3K7;CD58;POLR2J;PSMC5;IFNG;HDAC4 |
| Pathways in cancer | Casp3;MSH6;WNT9A;PIK3CB;WNT10B;PRKACA;GNAQ;MMP2;EGLN2 |
| Proteoglycans in cancer | CTTN;EZR;FZD9;WNT5B;PRKCG;Fzd4;MET;CDC42;TIMP3 |
| MicroRNAs in cancer | SOCS1;EZH2;SLC45A3;CCNE1;WNT3;CCND2;WNT3A;SLC7A1;RECK |
| Glioma | Pdgfa&Pdgfb;CALM4;MAPK1;SOS1;PIK3CB;SHC2;PTEN;PIK3R5;TRP53 |
| Non-small cell lung cancer | FOXO3;PRKCB;KRAS;ERBB2;PIK3CG;PIK3CB;RB1;PLCG1;AKT1 |
PLCG2 has several biochemical functions, for example, phosphatidylinositol phospholipase C activity, phospholipase C activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCG2 itself. We selected most functions PLCG2 had, and list some proteins which have the same functions with PLCG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | PLCD1A;EDNRA;CHRM5;PLCE1;PLD4;CCL5;PLCH1;PLCG2;PLCD1B |
| phospholipase C activity | ADORA1;PLCB3;PLCG1;PDIA3;PLCL1;PLCH2;PLCB2;PLCG2;PLCE1 |
| protein binding | IGF1;HIST1H2BE;WTAP;UBXN2B;MAP2K1;CDC42;PILRB;RAPGEF3;SLC41A3 |
| signal transducer activity | TAS2R134;VALOPA;CALCRLA;PTGER1B;OLFCG3;TAAR12B;OLFR502;GPR62;TRADD |
PLCG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCG2.
EGFR; ERBB2; PIK3R1; PSMD3; FSBP; PTTG1; TP53; HSPD1
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