| Description : |
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
147.9 kDa |
| AA Sequence : |
MSTTVNVDSLAEYEKSQIKRALELG TVMTVFSFRKSTPERRTVQVIMETR QVAWSKTADKIEGFLDIMEIKEIRP GKNSKDFERAKAVRQKEDCCFTILY GTQFVLSTLSLAADSKEDAVNWLSG LKILHQEAMNASTPTIIESWLRKQI YSVDQTRRNSISLRELKTILPLINF KVSSAKFLKDKFVEIGAHKDELSFE QFHLFYKKLMFEQQKSILDEFKKDS SVFILGNTDRPDASAVYLRDFQRFL IHEQQEHWAQDLNKVRERMTKFIDD TMRETAEPFLFVDEFLTYLFSRENS IWDEKYDAVDMQDMNNPLSHYWISS SHNTYLTGDQLRSESSPEAYIRCLR MGCRCIELDCWDGPDGKPVIYHGWT RTTKIKFDDVVQAIKDHAFVTSSFP VILSIEEHCSVEQQRHMAKAFKEVF GDLLLTKPTEASADQLPSPSQLREK IIIKHKKLGPRGDVDVNMEDKKDEH KQQGELYMWDSIDQKWTRHYCAIAD AKLSFSDDIEQTMEEEVPQDIPPTE LHFGEKWFHKKVEKRTSAEKLLQEY CMETGGKDGTFLVRESETFPNDYTL SFWRSGRVQHCRIRSTMEGGTLKYY LTDNLTFSSIYALIQHYRETHLRCA EFELRLTDPVPNPNPHESKPWYYDS LSRGEAEDMLMRIPRDGAFLIRKRE GSDSYAITFRARGKVKHCRINRDGR HFVLGTSAYFESLVELVSYYEKHSL YRKMRLRYPVTPELLERYNMERDIN SLYDVSRMYVDPSEINPSMPQRTVK ALYDYKAKRSDELSFCRGALIHNVS KEPGGWWKGDYGTRIQQYFPSNYVE DISTADFEELEKQIIEDNPLGSLCR GILDLNTYNVVKAPQGKNQKSFVFI LEPKQQGYPPVEFATDRVEELFEWF QSIREITWKIDTKENNMKYWEKNQS IAIELSDLVVYCKPTSKTKDNLENP DFREIRSFVETKADSIIRQKPVDLL KYNQKGLTRVYPKGQRVDSSNYDPF RLWLCGSQMVALNFQTADKYMQMNH ALFSLNGRTGYVLQPESMRTEKYDP MPPESQRKILMTLTVKVLGARHLPK LGRSIACPFVEVEICGAEYDNNKFK TTVVNDNGLSPIWAPTQEKVTFEIY DPNLAFLRFVVYEEDMFSDPNFLAH ATYPIKAVKSGFRSVPLKNGYSEDI ELASLLVFCEMRPVLESEEELYSSC RQLRRRQEELNNQLFLYDTHQNLRN ANRDALVKEFSVNENQLQLYQEKCN KRLREKRVSNSKFYSTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
