PRMT1 Protein


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Official Full Name protein arginine methyltransferase 1
Background This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Synonyms PRMT1; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2; protein arginine N-methyltransferase 1; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His/Myc
    • Myc
    • MBP
    • MYC/DDK
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRMT1-064H Recombinant Human PRMT1 Protein, GST-tagged E. coli GST
    Human PRMP1-678H Recombinant Human PRMP1, His-tagged Insect Cell His
    Human PRMT1-016H Recombinant Human PRMT1 Protein, GST-tagged E.coli GST
    Human PRMT1-123H Recombinant Human PRMT1 protein, T7/His-tagged E.coli T7/His
    Human PRMT1-1286H Recombinant Human PRMT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PRMT1-1761H Recombinant Human Protein Arginine Methyltransferase 1, His-MBP-tagged Human His/Myc
    Human PRMT1-181H Recombinant Human PRMT1, GST-tagged Sf9 Insect Cell GST
    Human PRMT1-1967H Recombinant Human PRMT1, GST-tagged E.coli GST
    Human PRMT1-3005H Recombinant Human PRMT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PRMT1-31112TH Recombinant Human PRMT1 protein, GST-tagged E.coli GST
    Human PRMT1-31114TH Recombinant Human PRMT1, MBP-tagged E.coli MBP
    Human PRMT1-3411H Recombinant Human PRMT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PRMT1-500HCL Recombinant Human PRMT1 lysate HEK293 N/A
    Human PRMT1-5040H Recombinant Human PRMT1 Protein, His-MBP-tagged Wheat Germ His/Myc
    Human PRMT1-5041H Recombinant Human PRMT1 Protein, GST-tagged Wheat Germ GST
    Human PRMT1-59H Recombinant Human PRMP1, His-tagged E.coli His
    Human PRMT1-623H Recombinant Human PRMT1 Mammalian Cell His
    Human PRMT2-67H Recombinant Human PRMT2, FLAG-tagged Sf9 Insect Cell Flag
    Mouse Prmt1-1171M Recombinant Mouse Prmt1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Prmt1-1762M Recombinant Mouse Protein Arginine N-methyltransferase 1, His-MBP-tagged Mouse His/Myc
    Mouse Prmt1-7228M Recombinant Mouse Prmt1 Protein, His-MBP-tagged E.coli His/Myc
    Rat PRMT1-4705R Recombinant Rat PRMT1 Protein Mammalian Cell His
    Rat Prmt1-711R Recombinant Rat Protein Arginine Methyltransferase 1 E.coli N/A
    Zebrafish PRMT1-10921Z Recombinant Zebrafish PRMT1 Mammalian Cell His
    Kit-1853 PRMT1 Chemiluminescent Assay Kit N/A
    Kit-1854 PRMT1 Homogeneous Assay Kit N/A
    Human PRMT1-1616H Recombinant Human Protein Arginine Methyltransferase 1, GST-tagged Sf9 Insect Cell GST

    PRMT1 involved in several pathways and played different roles in them. We selected most pathways PRMT1 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway S1PR1; MAPK12B; PLK4; PIK3R3A; KLF2B; KRAS; IRS1; PDPK1B; CCND2; IGF1

    PRMT1 has several biochemical functions, for example, N-methyltransferase activity, enzyme binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT1 itself. We selected most functions PRMT1 had, and list some proteins which have the same functions with PRMT1. You can find most of the proteins on our site.

    Function Related Protein
    N-methyltransferase activity HEMK1; PRMT1; METTL21D; PRMT8B; FAM86; METTL7B; PRDM11; METTL21A; PRDM13; DIMT1
    enzyme binding EGLN1; TNKS2; CALU; RAC1; GBP1; HLCS; ARPC4; GSTM4; HSPA8; CBS
    histone methyltransferase activity PRDM13; SUZ12; PRMT1; SUV39H1; CARM1; PRMT2; EED; PRMT6; EZH2
    histone methyltransferase activity (H4-R3 specific) PRMT6; PRMT8B; PRMT1; PRMT8; PRMT7
    identical protein binding NQO1; POU3F2; NIF3L1; TP53; COIL; HOOK1; C1QTNF2; KIRRELA; PARK2; KLHL7
    methyltransferase activity TOMT; FBLL1; CMTR2; WBP7; MGMT; KMT2A; EHMT1B; TRMT10C; SUV39H1A; METTL7B
    mitogen-activated protein kinase p38 binding PRMT1; SPAG9; TAB1; NFATC1; RPS6KA4
    poly(A) RNA binding SUGP1; MAGOH; EIF4H; SF3A1; ZC3H11A; ELAVL2; RBM5; MRPL32; FAM98C; EIF2C3
    protein binding HTR3E; TRP63; EFS; POSTN; ABT1; ZFP346; CCDC86; DRAM1; FOXD3; LILRB3
    protein methyltransferase activity FBLL1; N6AMT1; METTL7B; RNMTL1B; RNMTL1A; PRMT1; METTL11A; PRDM12; METTL23; TRMT10B
    protein-arginine N-methyltransferase activity PRDM13; PRMT8B; RNMTL1B; PRMT5; PRDM12; NDUFAF5; FBXO11; TRMT10B; PRMT2; METTL23
    protein-arginine omega-N asymmetric methyltransferase activity PRMT8B; PRMT6; PRMT8; PRMT7; PRMT2; PRMT3; CARM1; PRMT1

    PRMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT1.


    Fujimoto, K; Kurokawa, R; et al. Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. CELL AND BIOSCIENCE 4:-(2014).
    Bikkavilli, RK; Avasarala, S; et al. In vitro Methylation Assay to Study Protein Arginine Methylation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).

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