PRMT1

  • Official Full Name

    protein arginine methyltransferase 1

  • Overview

    This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
  • Synonyms

    PRMT1; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2; protein arginine N-methyltransferase 1; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|Myc
  • MBP
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRMT1-31112TH Active Recombinant Human PRMT1 protein, GST-tagged E.coli GST
Human PRMT2-67H Active Recombinant Human PRMT2, FLAG-tagged Sf9 Insect Cell Flag
Human PRMT1-181H Active Recombinant Human PRMT1, GST-tagged Sf9 Insect Cell GST
Human PRMT1-123H Recombinant Human PRMT1 protein, T7/His-tagged E.coli T7/His
Human PRMT1-31114TH Recombinant Human PRMT1, MBP-tagged E.coli MBP
Human PRMT1-59H Recombinant Human PRMP1, His-tagged E.coli His
Human PRMT1-5040H Active Recombinant Human PRMT1 Protein, His-MBP-tagged Wheat Germ His/Myc
Human PRMT1-623H Recombinant Human PRMT1 Mammalian Cell His
Human PRMT1-1967H Recombinant Human PRMT1, GST-tagged E.coli GST 1-343aa
Human PRMP1-678H Recombinant Human PRMP1, His-tagged Insect Cell His
Human PRMT1-1761H Recombinant Human Protein Arginine Methyltransferase 1, His-MBP-tagged Human His/Myc
Human PRMT1-1616H Recombinant Human Protein Arginine Methyltransferase 1, GST-tagged Sf9 Insect Cell GST
Human PRMT1-5041H Recombinant Human PRMT1 Protein, GST-tagged Wheat Germ GST
Human PRMT1-500HCL Recombinant Human PRMT1 lysate HEK293 N/A
Human PRMT1-3680HF Recombinant Full Length Human PRMT1 Protein In Vitro Cell Free System 353 amino acids
Human PRMT1-3005H Recombinant Human PRMT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRMT1-3411H Recombinant Human PRMT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRMT1-016H Recombinant Human PRMT1 Protein, GST-tagged E.coli GST 2-371
Human PRMT1-1770H Recombinant Human PRMT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRMT1-064H Recombinant Human PRMT1 Protein, GST-tagged E.coli GST 2-371
Human PRMT1-5849H Recombinant Human PRMT1 Protein (Met1-Arg343), N-His tagged E.coli N-His Met1-Arg343
Human PRMT1-1286H Recombinant Human PRMT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRMT1-1770H-B Recombinant Human PRMT1 Protein Pre-coupled Magnetic Beads HEK293
Human PRMT1-1985H Recombinant Human PRMT1 Protein, His&GST-tagged E.coli N-His&GST Gly165-Arg371
Human PRMT1-309HFL Active Recombinant Full Length Human PRMT1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Prmt1-1762M Recombinant Mouse Protein Arginine N-methyltransferase 1, His-MBP-tagged Mouse His/Myc
Mouse Prmt1-7228M Active Recombinant Mouse Prmt1 Protein, His-MBP-tagged E.coli His/Myc 1-353
Mouse Prmt1-1171M Recombinant Mouse Prmt1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Prmt1-711R Recombinant Rat Protein Arginine Methyltransferase 1 E.coli N/A
Rat PRMT1-4705R Recombinant Rat PRMT1 Protein Mammalian Cell His
Rat PRMT1-4364R-B Recombinant Rat PRMT1 Protein Pre-coupled Magnetic Beads HEK293
Rat PRMT1-4364R Recombinant Rat PRMT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PRMT1-10921Z Recombinant Zebrafish PRMT1 Mammalian Cell His
Kit-1854 PRMT1 Homogeneous Assay Kit N/A
Kit-1853 PRMT1 Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PRMT1 involved in several pathways and played different roles in them. We selected most pathways PRMT1 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayG6PC2;GADD45AA;G6PCA.1;PLK2B;HOMER1B;KRAS;INS2;GRB2B;NLK1

PRMT1 has several biochemical functions, for example, N-methyltransferase activity, enzyme binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT1 itself. We selected most functions PRMT1 had, and list some proteins which have the same functions with PRMT1. You can find most of the proteins on our site.

Function Related Protein
N-methyltransferase activityPRDM13;PRMT8B;HEMK1;RNMTL1B;FAM86;METTL23;NDUFAF5;PRDM12;METTL21D
enzyme bindingDDX5;ZFP346;PRKCD;CBS;NOTCH3;RCOR1;AXIN1;BIRC7;PIAS3
histone methyltransferase activityPRMT6;CARM1;PRMT1;PRDM13;EED;EZH2;PRMT2;SUZ12;SUV39H1
histone methyltransferase activity (H4-R3 specific)PRMT7;PRMT8;PRMT6;PRMT8B;PRMT1
identical protein bindingCD74;PRMT8;S100B;ABCD1;POU3F2;B2M;SYT9;VIL1;IFI16
methyltransferase activityGART;SETD9;SUV39H1B;METTL25;SKINT8;DNMT4;DIMT1;METTL6;Mettl11b
mitogen-activated protein kinase p38 bindingRPS6KA4;SPAG9;NFATC1;PRMT1;TAB1
poly(A) RNA bindingRPL7A;GRB2;SRSF3;DHX32;FCF1;SPATS2L;RPP25;HNRNPH2;ZCCHC8
protein bindingRAB41;WDR6;MORF4L1;GTF2A1L;GZMB;CAPG;TIMELESS;ZWILCH;AGBL1
protein methyltransferase activityRNMTL1A;NDUFAF5;PRMT1;NTMT1;FBLL1;HEMK1;PRDM12;METTL21A;RNMTL1B
protein-arginine N-methyltransferase activityDIMT1;PRMT3;PRDM11;PRDM13;TRMT10B;PRMT1;PRMT8B;METTL7B;METTL23
protein-arginine omega-N asymmetric methyltransferase activityPRMT3;CARM1;PRMT6;PRMT1;PRMT7;PRMT8;PRMT2;PRMT8B

PRMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT1.

HNRNPR; NRIP1; HNRNPK; SPEG; WDYHV1

Research Area

Related articles

Fujimoto, K; Kurokawa, R; et al. Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. CELL AND BIOSCIENCE 4:-(2014).
Bikkavilli, RK; Avasarala, S; et al. In vitro Methylation Assay to Study Protein Arginine Methylation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).
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