Recombinant Mouse Protein Arginine N-methyltransferase 1, His-MBP-tagged

• Cat.No.: Prmt1-1762M
• Product Overview: Recombinant mousePRMT1, fused to His-MBP tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.

Specification

• Species: Mouse
• Source: Mouse
• Tag: His&Myc
• Description: Protein arginineN-methyltransferase 1 (PRMT1) is a type I methyltransferase that transfers amethyl group from S-adenosylmethionine to guanidino nitrogens of arginineresidues to form monomethylarginine and asymmetric dimethylarginine.Functions of type I arginine methylation in proteins may include regulationof transcription, modulation of the affinity of nucleic acid-bindingproteins, regulation of interferon signaling pathways, and targeting ofnuclear proteins. Mouse PRMT1 shares 99.9% sequence identity with the humanproteins.
• Concentration: 1 mg/ml
• Form: Supplied as a liquidin 40 mM Tris, pH 8.0, containing 100 mM NaCl, 4 mM MgCl2, 2 mM DTT, and 40%glycerol.
• Purity: > 90% pure bySDS-PAGE
• Sequence: 11-353 amino acids:MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFWAHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEIPALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNKHMNAD
• Molecular Mass: 84 kDa (750 aa)
• Applications: SDS-PAGE
• Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or -70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: Prmt1

Gene Information

• Gene Name: Prmt1protein arginine N-methyltransferase 1 [ Mus musculus ]
• Synonyms: Prmt1; proteinarginine N-methyltransferase 1; Mrmt1; Hrmt1l2; AW214366;6720434D09Rik; OTTMUSP00000022387; OTTMUSP00000022390; OTTMUSP00000022391;OTTMUSP00000022392; arginine N-methyltransferase 1; histone-arginineN-methyltransferase PRMT1; heterogeneous nuclear ribonucleoproteinsmethyltransferase-like 2; EC 2.1.1.125
• Gene ID: 15469
• mRNA Refseq: NM_019830
• Protein Refseq: NP_062804
• UniProt ID: Q9JIF0
• Chromosome Location: 7 B4; 7 23.1 cM
• Pathway: Androgen ReceptorSignaling Pathway; Tryptophan metabolism; mRNA processing
• Function: protein binding;methyltransferase activity; histone-arginine N-methyltransferase activity;histone methyltransferase activity (H4-R3 specific); histonemethyltransferase activity; enzyme binding; core promoter proximal region DNAbinding; [cytochrome c]-arginine N-methyltransferase activity;N-methyltransferase activity; protein methyltransferase activity;protein-arginine omega-N asymmetric methyltransferase activity; snoRNPbinding; transferase activity