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PRPS2

  • Official Full Name

    phosphoribosyl pyrophosphate synthetase 2

  • Overview

    This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants.
  • Synonyms

    PRPS2; phosphoribosyl pyrophosphate synthetase 2; ribose-phosphate pyrophosphokinase 2; PRS II; ribose phosphate diphosphokinase 2; EC 2.7.6.1; Phosphoribosyl pyrophosphate synthetase II; PPRibP; Ribose phosphate pyrophosphokinase II; PRS-II; PPRibP synthetase; OTTHUMP00000022921; OTTHUMP00000214964; OTTHUMP00000214965; ribose-phosphate diphosphokinase 2; phosphoribosyl pyrophosphate synthase II; PRSII;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRPS2-90H Recombinant Human PRPS2, His-tagged E.coli His
Human PRPS2-181H Recombinant Human PRPS2, His-tagged HEK293 His
Human PRPS2-189H Recombinant Human PRPS2 protein, T7/His-tagged E.coli T7/His
Human PRPS2-374H Recombinant Human PRPS2 protein, His-tagged E.coli His Met1-Leu318
Human PRPS2-505HCL Recombinant Human PRPS2 lysate HEK293 N/A
Human PRPS2-3030H Recombinant Human PRPS2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRPS2-6013H Recombinant Human PRPS2 Protein (Pro2-Leu318), C-His tagged Mammalian cells C-His Pro2-Leu318
Human PRPS2-3750H Recombinant Human PRPS2 protein, GST-tagged E.coli GST 143-273 aa
Mouse Prps2-479M Recombinant Mouse Prps2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat PRPS2-4724R Recombinant Rat PRPS2 Protein Mammalian Cell His
Rat PRPS2-4383R Recombinant Rat PRPS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRPS2-4383R-B Recombinant Rat PRPS2 Protein Pre-coupled Magnetic Beads HEK293
Chicken PRPS2-1411C Recombinant Chicken PRPS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRPS2 Related Articles

PRPS2 involved in several pathways and played different roles in them. We selected most pathways PRPS2 participated on our site, such as Pentose phosphate pathway, Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose phosphate pathwayPRPS1A;GPI1;FBP1;ALDOCA;FBP1A;PRPS1B;PGD;deoC;H6PD
Purine metabolismXDH;PKM;ADSSL1;ADSS;POLR2J2;PRIM2;POLE4;POLR1E;GUCY1A3
Metabolic pathwaysMLYCD;PMM1;CYP2C45;HPSE2;ACSM2;NDUFB7;DAO;SDSL;ATP6AP1
Carbon metabolismPRPS1;IDH3B;GOT2A;SDHDB;GOT2B;AMT;ACAT2;ALDH6A1;IDH3G
Biosynthesis of amino acidsPCXB;PFKMA;GM5506;RPE;GPT;PYCR1A;PFKP;ARG2;ALDOAB

PRPS2 has several biochemical functions, for example, ADP binding, AMP binding, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPS2 itself. We selected most functions PRPS2 had, and list some proteins which have the same functions with PRPS2. You can find most of the proteins on our site.

Function Related Protein
ADP bindingPRKAG2;MYO3A;CHORDC1;PRPS2;ACTA1;TAP1;APAF1;HSP104;LONP1
AMP bindingPRPS1;PRKAG1;ACSS2;CYB5R3;PRKAG2;PRPS2;PYGM;FBP1;ACSS1
ATP bindingACSM1;PIK3C2G;DYRK3;ASNS;FDXACB1;ATAD1A;VMHC;MYLK4;NARS
GDP bindingRAP2B;RHOA;RAP1B;GEM;RAB4A;RAB9B;RAB3B;SRP54;RAN
carbohydrate bindingCDIPT;CD209C;GALNTL2;Cd209g;SELL;REG3G;Chil3;CD209A;CLEC4E
identical protein bindingIRF3;ALDOA;TRAF2;RAF1;MSTN;PFKFB1;ETNPPL;SEPHS1;NUFIP1
kinase activityPI4KAP2;PFKFB4L;MKNK2B;LRRK2;STK25B;ACVR1L;BCKDK;JAK2A;RPS6KA3B
magnesium ion bindingPTENA;NIM1;COMTA;ABL1;MAP2K7;ADSS;STK3;DXO;ALPI
protein bindingNCLN;DNAJC10;SIRT3;KCNQ4;SMUG1;GSDMA2;C17orf82;MOBKL1A;PLK2
protein homodimerization activityNR2F2;UPK1A;NLGN4X;ADH1;ZBTB4;HNF4A;SOD1;ECT2;ENPP1
ribose phosphate diphosphokinase activityPRPS2;PRPS1B;PRPS1A;PRPS1L1;PRPS1;PRPSAP1

PRPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPS2.

PRPS1; PRPSAP1; NOTCH2NL; WDYHV1

Cunningham, JT; Moreno, MV; et al. Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. CELL 157:1088-1103(2014).
Fridman, A; Saha, A; et al. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. BIOCHEMICAL JOURNAL 454:91-99(2013).
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