PTK2

  • Official Full Name

    protein tyrosine kinase 2

  • Overview

    Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs). Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). These two kinases have molecular mass between 110-125 kDa and are closely related in their structure. The presence<br/>of two proline-rich motifs within the C-terminal domains is conserved. FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains. The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains. FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, survival, and migration. Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways. Recent study reveals that FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice.
  • Synonyms

    PTK2; protein tyrosine kinase 2; FAK; FADK; FAK1; FADK 1; FRNK; PPP1R71; pp125FAK; Protein-tyrosine kinase 2; focal adhesion kinase 1; FADK 1; FAK-related non-kinase polypeptide; protein phosphatase 1, regulatory subunit 71; P_001186578.1; EC 2.7.10.2; EC 2.7.10; NP_005598.3; EC 2.7.10.2; NP_722560.1; OTTHUMP00000226325; OTTHUMP00000226326; OTTHUMP00000226334; OTTHUMP00000226350; OTTHUMP00000226586; OTTHUMP00000226318; OTTHUMP00000226320;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Marsupials
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTK2-600H Active Recombinant Human PTK2, His-tagged Sf9 Insect Cell His
Human PTK2-78H Active Recombinant Human PTK2(411-686) Protein, N-His-tagged Sf21 His 411-686 aa
Human PTK2-90H Recombinant Human PTK2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTK2-44H Recombinant Human PTK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human PTK2-6827H Recombinant Human PTK2 protein, His & T7-tagged E.coli His/T7 Gly798~Ala1041
Human PTK2-28820TH Recombinant Human PTK2 Sf9 Insect Cell N/A 1052 amino acids
Human PTK2-1901H Recombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged Sf9 Insect Cell His
Human PTK2-309H Recombinant Human PTK-2 Protein Tyrosine Kinase 2, His-tagged, Active Sf9 Insect Cell His
Human PTK2-38H Recombinant Human PTK2, GST-tagged Sf9 Insect Cell GST
Human PTK2-2700HCL Recombinant Human PTK2 293 Cell Lysate HEK293 N/A
Human PTK2-4821H Recombinant Human PTK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTK2-6080H Recombinant Human PTK2 Protein (Gly798-Ala1041), N-His tagged E.coli N-His Gly798-Ala1041
Human PTK2-4856H Recombinant Human PTK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTK2-3477HFL Recombinant Full Length Human PTK2 protein, Flag-tagged Mamanlian cells Flag
Human PTK2-0739H Recombinant Human PTK2 Protein (M1-H1052), Tag Free Insect Cell No tag M1-H1052
Human PTK2-0740H Recombinant Human PTK2 Protein (M1-H1052), GST tagged Insect Cell GST M1-H1052
Mouse PTK2-13657M Recombinant Mouse PTK2 Protein Mammalian Cell His
Mouse Ptk2-1013M Recombinant Mouse Ptk2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse PTK2-7265M Recombinant Mouse PTK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTK2-7265M-B Recombinant Mouse PTK2 Protein Pre-coupled Magnetic Beads HEK293
Rat PTK2-4822R Recombinant Rat PTK2 Protein Mammalian Cell His
Rat PTK2-4481R Recombinant Rat PTK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTK2-4481R-B Recombinant Rat PTK2 Protein Pre-coupled Magnetic Beads HEK293
Marsupials PtK2-1434M PtK2 (Marsupial kidney) whole cell lysate N/A
Chicken PTK2-6985C Recombinant Chicken PTK2 Mammalian Cell His
Chicken PTK2-1272C Recombinant Chicken PTK2 Protein (376-683 aa), GST-tagged E.coli GST 376-683 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PTK2 involved in several pathways and played different roles in them. We selected most pathways PTK2 participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayHBEGFA;ERBB3B;HRASA;BRAF;PAK2A;GRB2;MAPK1;MAP2K7;MAPK9
Chemokine signaling pathwayCXCL11;CCL8;GSK3A;CCR8;CCL2;CCL13;RAF1;VAV1;CDC42
PIK-Akt signaling pathwayTNXB;STK11;GNGT1;IL4;GNG10;PPP2R5C;RPS6KB2;Fasl;MLST8
Axon guidanceCLTB;COL4A5;GDNF;COL6A1;FGFR1B;CREB1B;CSK;PEA15;DUSP10
VEGF signaling pathwayMAPK12;PLCG1;PLA2G4A;SPHK2;PPP3R2;PIK3R1;RAF1;RAC1;PPP3CA
Focal adhesionMET;PPP1R12B;ITGB8;TNK1;FLT1;PXNA;ILK;HRASB;PDPK1B
Leukocyte transendothelial migrationNCF4;RAC1;CLDN23;THY1;PIK3CB;RAC2;CLDN18;PTK2B;PRKCG
Regulation of actin cytoskeletonBDKRB2;Pdgfa&amp;Pdgfb;SCINLB;BRK1;FGF1;SOS1;PIP5K1C;TMSB4X;FGF13A
Bacterial invasion of epithelial cellsDNM3;SEPT3;SEPT6;CBL;PIK3R5;PIK3CD;SHC4;CTTN;CTNNA3
AmoebiasisLAMB2;IL12A;LAMB1;ARG1;IL10;ACTN1;COL27A1;ADCY1;IL1R1
Pathways in cancerAPC2;FZD6;MSH2;CYCS;TRAF1;FZD2;TGFBR2;GNAI3;FZD5
Transcriptional misregulation in cancerTLX3;Bcl2a1b;MEN1;FUS;Pdgfa&amp;Pdgfb;CLSTN2;WT1;MET;ZEB1
Proteoglycans in cancerPAK1;MMP2;PPP1CB;CBL;CAMK2D;HPSE;MAPK13;FZD10;TGFB2
Small cell lung cancerITGA3;TRAF4;TRAF6;LAMC1;LAMA1;NOS2;APAF1;PIK3R1;BIRC3

PTK2 has several biochemical functions, for example, ATP binding, JUN kinase binding, SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2 itself. We selected most functions PTK2 had, and list some proteins which have the same functions with PTK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCDKL2;MAPK8A;KARS;UBE2D2;ABL1;ABCA4A;GATB;CSNK1DB;SPATA5L1
JUN kinase bindingSPAG9;MAPK8IP3;PTK2;GSTP1;MAD2L2;SPAG9A
SH2 domain bindingARHGAP5;SRC;SIT1;NUP62;DAG1;AFAP1L2;INPPL1;LAT2;LAX1
actin bindingRP2;TPM4;DAAM1B;PLS3;SCINLB;SMTN;MYO1G;TPMA;FRG1
non-membrane spanning protein tyrosine kinase activityABL1;TXK;JAK1;FER;YRK;ITK;SRMS;TEC;SRC
protein bindingPDLIM4;HCFC1;TRPM8;IL13RA1;TRAFD1;NUP37;E2F8;JPH2;PSMD5
protein kinase activityCSNK1G2B;LTK;STK24;SRPK1;PPP1R9B;STK24A;NEK5;ACVR1BA;SGK2A
protein kinase bindingCDC42;PPP1R12A;HSP90AB1;MAP3K2;PIFO;THY1;GCSAM;SPDYA;ELP2
protein tyrosine kinase activityERBB3B;DYRK4;EPHA2A;DYRK1B;YES1;IGF1RB;FGFR3;SRC;FGFR1A
receptor bindingHLA-G;ARPP19A;CHRNA10;F2;GSTK1;WNT7A;ANGPTL1;MAP7;HSPA1B
signal transducer activityNFKBIB;SLC44A2;NEK6;TACR3A;TNK1;OR115-6;MC5RA;VMN1R40;PLCB1

PTK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2.

SRC; PXN

Research Area

Related articles

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Weisser, M; Yeh, RF; et al. PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia. BLOOD 124:420-425(2014).
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