PYCARD
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Official Full Name
PYD and CARD domain containing -
Overview
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues. -
Synonyms
PYCARD;PYD and CARD domain containing;apoptosis-associated speck-like protein containing a CARD;ASC;CARD5;TMS 1;target of methylation-induced silencing 1;caspase recruitment domain-containing protein 5;TMS;TMS1;TMS-1;MGC10332
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Insect Cells
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Yeast
- E. coli
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
PYCARD involved in several pathways and played different roles in them. We selected most pathways PYCARD participated on our site, such as NOD-like receptor signaling pathway,Cytosolic DNA-sensing pathway,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYCARD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytosolic DNA-sensing pathway | POLR3G,POLR3B,IFNB,TREX1,IFNA5,RIPK1L,IFNA4,IKBKB,CCL5,POLR3E |
| NOD-like receptor signaling pathway | MAPK1,MAPK11,MAPK8A,NFKBIB,NLRP3,HSP90AB1,IL1B,CARD18,MAPK13,NLRP1 |
| Legionellosis | EEF1A2,IL12A,SEC22B,ITGB2,C3,TNF,CASP8,NAIP1,NFKB1,Itgam&Itgb2 |
| Pertussis | IRF1,CALM2,NFKB1,C1R,C1QB,TNF,IRAK4,CXCL5,IL6,C1RA |
| Salmonella infection | DYNC1I1,TLR4BB,WAS,RAB7,RHOGD,NOS2,DYNC2H1,RAC1B,CASP1,TJP1 |
| Influenza A | IFNB,PIK3CA,IFIH1,NXT2,HLA-DRB4,HNRNPUL1,KPNA2,IFNA13,PRKCA,RNASEL |
Protein Function
PYCARD has several biochemical functions, for example, BMP receptor binding,Pyrin domain binding,cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by PYCARD itself. We selected most functions PYCARD had, and list some proteins which have the same functions with PYCARD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | USF1,TSPAN17,GSTM7,RYR2,PRKCH,SPDL1,HIST1H2AE,CREB1,CYP2A4,RAC1 |
| protein binding | PTPN12,DEF6,ST8SIA5,CUBN,HIP1R,SLC7A1,DCC,SPAT-1,PPP1R3C,ARHGEF2 |
| identical protein binding | SLC22A1,LRP6,CIDEB,UBE2G2,KHDC1B,PRKAB2,EGFR,DAPK3,MTSS1,AGER |
| BMP receptor binding | BMP3,BMP2,BMP7A,BMP8A,BMP2B,BMP7B,BMP7,BMP8B,BMP6,BMP4 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | CTSC,MAPK9,CARD8,NLRP12,CTSH,RPS27L,CASP1,APAF1,NOD1,NLRP1 |
| Pyrin domain binding | CASPA,NLRP2 |
| protease binding | C10orf2,ADRM1,SELL,INS,DPP4,ADAMTS4,TIMP4,ITGAV,SERPINA1E,DERL1 |
| tropomyosin binding | S100A6,TMOD2,TNNT3,TMOD4,CALD1,TMOD3,TNNT2A,NEBL,LMOD3,TNNT1 |
| interleukin-6 receptor binding | ADAM17,IL6,CNTF,ERAP1 |
Interacting Protein
PYCARD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYCARD here. Most of them are supplied by our site. Hope this information will be useful for your research of PYCARD.
AIM2;NLRP3
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References
- Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).
