Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

PYCARD

  • Official Full Name

    PYD and CARD domain containing

  • Overview

    Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
  • Synonyms

    PYCARD; PYD and CARD domain containing; apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; TMS 1; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; TMS; TMS1; TMS-1; MGC10332;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect Cells
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PYCARD-29108H Recombinant Human PYCARD, GST-tagged Wheat Germ GST
Human PYCARD-2648HCL Recombinant Human PYCARD 293 Cell Lysate HEK293 Non
Human PYCARD-2649HCL Recombinant Human PYCARD 293 Cell Lysate HEK293 Non
Human PYCARD-2650HCL Recombinant Human PYCARD 293 Cell Lysate HEK293 Non
Human PYCARD-86HFL Recombinant Full Length Human PYCARD Protein, C-Flag-tagged Mammalian cells Flag
Human PYCARD-415HF Recombinant Full Length Human PYCARD Protein, GST-tagged In Vitro Cell Free System GST 149 amino acids
Human PYCARD-4939H Recombinant Human PYCARD protein, His&Myc-tagged E.coli His&Myc 1-195aa
Human PYCARD-01H Recombinant Human PYCARD Protein, Myc/DDK-tagged HEK293T Myc&DDK
Human PYCARD-0130H Recombinant Human PYCARD Protein (Leu112-Ser195), N-His-tagged E.coli His Leu112-Ser195
Human PYCARD-12H Recombinant Human PYCARD protein, His tagged Baculovirus-Insect Cells His
Human PYCARD-5929H Recombinant Human PYCARD protein, His&Myc-tagged HEK293 His&Myc 1-195aa
Human PYCARD-6130H Recombinant Human PYCARD protein(1-93aa), His-tagged E.coli His 1-93aa
Human PYCARD-1814H Recombinant Human PYCARD Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human PYCARD-080H Recombinant Human PYCARD Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Myc&DDK
Human PYCARD-1814H-B Recombinant Human PYCARD Protein Pre-coupled Magnetic Beads HEK293
Human PYCARD-3266H Recombinant Human PYCARD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Mouse Pycard-6744M Recombinant Mouse Pycard protein E.coli Non 1-193a.a.
Mouse Pycard-4778M Recombinant Mouse Pycard protein, His&Myc-tagged E.coli His&Myc 1-193aa
Mouse Pycard-5433M Recombinant Mouse Pycard protein, His-tagged Yeast C-His 1-193aa
Rhesus Macaque PYCARD-3718R Recombinant Rhesus monkey PYCARD Protein, His-tagged Mammalian Cell His
Rhesus Macaque PYCARD-3535R-B Recombinant Rhesus Macaque PYCARD Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PYCARD-3535R Recombinant Rhesus Macaque PYCARD Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Zebrafish PYCARD-9047Z Recombinant Zebrafish PYCARD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PYCARD involved in several pathways and played different roles in them. We selected most pathways PYCARD participated on our site, such as NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYCARD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NOD-like receptor signaling pathwayIL-8;IL6;TAB3;MAP3K7;TRIP6;NLRP1;IKBKG;PSTPIP1;SGUT1
Cytosolic DNA-sensing pathwayMB21D1;IFNA2;OSTN;POLR2H;NFKBIAB;IFNA4;IKBKE;RIPK3;IFNA10
Salmonella infectionKLC4;MAPK8B;CCL3L3;IL18;IL6;PKN1;IL8L1;DYNC1I2A;TLR4
PertussisCALM4;SERPING1;IRF1;Hc;TNF;MAPK10;CXCL5;NOS2;MAPK3
LegionellosisPYCARD;BCL2L13;HSPA6;NAIP7;SAR1B;HSF1;NFKB1;NFKBIA;Casp3
Influenza ARAF1;MYD88;CXCL8;IFNA8;IFNA21;HNRNPUL1;PRSS3;AGFG1;HLA-DRB4

PYCARD has several biochemical functions, for example, BMP receptor binding, Pyrin domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by PYCARD itself. We selected most functions PYCARD had, and list some proteins which have the same functions with PYCARD. You can find most of the proteins on our site.

Function Related Protein
BMP receptor bindingBMP2B;BMP8B;BMP2;BMP5;BMP7;BMP4;PYCARD;BMP3;BMP6
Pyrin domain bindingNLRP2;CASPA;PYCARD
cysteine-type endopeptidase activator activity involved in apoptotic processCASP1;NLRP12;RPS27L;MAPK9;GNB2L1;CTSH;PYCARD;BCL2L13;NOD1
enzyme bindingNOTCH3;FAM84B;UGT1A7;MAPK8;PPP1R3D;HSPA8;PPP3CB;TNKS2;PPP3CA
identical protein bindingIIGP1;VWA2;PLN;CLDN14;DAPK3;SP100;MCM10;SSNA1;THG1L
interleukin-6 receptor bindingADAM17;ERAP1;PYCARD;CNTF;IL6
myosin I binding
protease bindingMBP;SERPINC1;MALT1;TNF;TRIP4;SERPINE1;INS1;FN1;Casp3
protein bindingKCNE1;NFIX;SOCS4;TTC35;DFFA;CCDC50;CDC5L;SMPD1;KIF23
protein homodimerization activityADH1;PLOD1;PAFAH1B1;ABCD1;Anks6;KCNN2;FLNA;SLK;ANG
tropomyosin bindingTMOD3;LMOD2A;TMOD4;NEBL;LMOD3;CALD1;LMOD1;S100A6;PYCARD

PYCARD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYCARD here. Most of them are supplied by our site. Hope this information will be useful for your research of PYCARD.

AIM2; NLRP3

Research Area

Related articles

Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).
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