RASGRP1

  • Official Full Name

    RAS guanyl releasing protein 1 (calcium and DAG-regulated)

  • Overview

    This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

  • Synonyms

    RASGRP1;RAS guanyl releasing protein 1 (calcium and DAG-regulated);V;RASGRP;hRasGRP1;CALDAG-GEFI;CALDAG-GEFII;RAS guanyl-releasing protein 1;ras activator RasGRP;RAS guanyl nucleotide-releasing protein 1;calcium and DAG-regulated guanine nucleotide exchange factor II;guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
  • Flag
  • GST

    Involved Pathway

    RASGRP1 involved in several pathways and played different roles in them. We selected most pathways RASGRP1 participated on our site, such as ARMS-mediated activation,Activation of RAS in B cells,Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DAP12 signaling DUSP10,NRG4,SPRED2,DUSP4,GRAP2A,FGF18B,AGO2,HBEGF,PEA15A,FGF20A
    DAP12 interactions FRS3,PAQR3B,CLEC5A,SPRED1,AGO3,FGFR1B,SPRED2,CD300E,ADRBK1,AHCYL1
    Axon guidance PEA15A,EFNB1,CSF2RA,EPHA2A,SPTBN2,EFNB3,RANBP9,EPHB3A,DUSP7,NEFLB
    ARMS-mediated activation CRK,KBTBD7,DUSP1,SPNA1,PSMD5,CNKSR1,PSMD9,PSMA8,SPTB,FGF8B
    Adaptive Immune System CTSO,RAPGEF3,SH2D1B,OSBPL1A,ERAP2,HLA-DQB2,KLB,CD207,CD300LG,ASB11
    Cytokine Signaling in Immune system KPNA3,GHRB,EIF4G1,SPRED1,IFIT2,ARIH1,ISG20,EDARADD,IFIT8,FRS2
    Developmental Biology DUSP10,PAQR3B,KALRN,ITSN1,SEMA4D,COL4A5,LEFTY1,PHB,DCC,SDCBP

    Protein Function

    RASGRP1 has several biochemical functions, for example, Ras guanyl-nucleotide exchange factor activity,calcium ion binding,diacylglycerol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP1 itself. We selected most functions RASGRP1 had, and list some proteins which have the same functions with RASGRP1. You can find most of the proteins on our site.

    Function Related Protein
    guanyl-nucleotide exchange factor activity P2RY12,ARHGEF3L,FGD1,ARHGEF1B,ARHGEF19,FAM116B,ARHGEF37,RALGPS2,GCGR,BCAR3
    diacylglycerol binding UNC13C,TRPC2,RASGRP3,UNC13B,RASGRP2,UNC13A,CDIPT,RASGRP4
    zinc ion binding TCEA1,CA5A,LIN28B,ADAMTS7,ESRRA,CRIP1,DUSP12,S100A13,MLL1,TRIM68
    calcium ion binding PCDH1GB9,CALRL2,VSNL1A,NECAB3,ELTD1,DGKA,CCDC167,TNNC1,SLC25A25,PVALB6
    protein homodimerization activity AOC3,GZMA,BCL2A1,NR6A1B,BCL2L10,BNIP3L,CLN6,PDCD6IP,CHRNA7,ADD1
    Ras guanyl-nucleotide exchange factor activity ADRB1,RGL2,RASGEF1A,RAPGEF4,RAB3A,RASGRP3,RASGEF1BB,SOS1,RAPGEF5,RASGRP4
    phosphatidylserine binding ANXA13,GAP43,CPNE1,AXL,THBS1,MARK1,PLCD1,GAS6,OSBPL8,SCARB1
    phosphatidylcholine binding APOA1,NF1,GPR119,VPS24,APOA4A,SERPINA5,CETP,GPR12,APOA4B.1,CHMP2A
    lipid binding DBI,APOA4,FNBP1,PACSIN1B,GPIHBP1,APOC2,FFAR3,PTGS2,FFAR2,S1PR4

    Interacting Protein

    RASGRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP1.

    Dlg4;PPM1B;VHL

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