| Description : |
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
90.4 kDa |
| AA Sequence : |
MGTLGKAREAPRKPSHGCRAASKAR LEAKPANSPFPSHPSLAHITQFRMM VSLGHLAKGASLDDLIDSCIQSFDA DGNLCRSNQLLQVMLTMHRIVISSA ELLQKVITLYKDALAKNSPGLCLKI CYFVRYWITEFWVMFKMDASLTDTM EEFQELVKAKGEELHCRLIDTTQIN ARDWSRKLTQRIKSNTSKKRKVSLL FDHLEPEELSEHLTYLEFKSFRRIS FSDYQNYLVNSCVKENPTMERSIAL CNGISQWVQLMVLSRPTPQLRAEVF IKFIQVAQKLHQLQNFNTLMAVIGG LCHSSISRLKETSSHVPHEINKVLG EMTELLSSSRNYDNYRRAYGECTDF KIPILGVHLKDLISLYEAMPDYLED GKVNVHKLLALYNHISELVQLQEVA PPLEANKDLVHLLTLSLDLYYTEDE IYELSYAREPRNHRAPPLTPSKPPV VVDWASGVSPKPDPKTISKHVQRMV DSVFKNYDHDQDGYISQEEFEKIAA SFPFSFCVMDKDREGLISRDEITAY FMRASSIYSKLGLGFPHNFQETTYL KPTFCDNCAGFLWGVIKQGYRCKDC GMNCHKQCKDLVVFECKKRAKNPVA PTENNTSVGPVSNLCSLGAKDLLHA PEEGPFTFPNGEAVEHGEESKDRTI MLMGVSSQKISLRLKRAVAHKATQT ESQPWIGSEGPSGPFVLSSPRKTAQ DTLYVLPSPTSPCPSPVLVRKRAFV KWENKDSLIKSKEELRHLRLPTYQE LEQEINTLKADNDALKIQLKYAQKK IESLQLEKSNHVLAQMEQGDCSTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
