RCAN1
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Official Full Name
regulator of calcineurin 1
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Overview
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. -
Synonyms
RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1 , DSCR1; calcipressin-1; Adapt 78; Adapt78; Calcipressin 1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1_HUMAN; RCN 1; RCN1; OTTHUMP00000108619; OTTHUMP00000108620; OTTHUMP00000108621; OTTHUMP00000108622; OTTHUMP00000214669; OTTHUMP00000214670; near DSCR proline-rich protein; calcium and oxidant-inducible mRNA; Down syndrome critical regi;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
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- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- HIS
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- RCAN1 Related Articles
RCAN1 involved in several pathways and played different roles in them. We selected most pathways RCAN1 participated on our site, such as Calcium signaling in the CD4+ TCR pathway, MicroRNAs in cardiomyocyte hypertrophy, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling in the CD4+ TCR pathway | CSF2;CHP;RCAN1;JUNB;POU2F1;RCAN2;AKAP5;FKBP1A;BATF3 |
| MicroRNAs in cardiomyocyte hypertrophy | CTF1;RCAN1;MYEF2 |
| Notch-mediated HES/HEY network | RCAN1;GATA1;CTBP1;TLE1;HEY1;YY1;ASCL1;GATA6;MYOD1 |
| Oxytocin signaling pathway | MYLK2;PLCB1;PPP3R1;GNAS;MAP2K1;CACNA2D1;CACNA2D4;CAMK2G;PRKACA |
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | CHP;FKBP8;RCAN2;RCAN1 |
| Thyroid hormone signaling pathway | TBC1D4;WNT4;PLCG2;NCOA1;MED1;MAP2K2;ITGB3;RXRG;NOTCH3 |
RCAN1 has several biochemical functions, for example, DNA binding, calcium-dependent protein serine/threonine phosphatase regulator activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCAN1 itself. We selected most functions RCAN1 had, and list some proteins which have the same functions with RCAN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP280D;DDB2;FOXA;HOXC13B;ANG3;LBX1B;FAM170A;ASXL1;ZNF292A |
| calcium-dependent protein serine/threonine phosphatase regulator activity | RCAN3;RCAN1A;RCAN1;RCAN2 |
| identical protein binding | MUL1;CLDN4;RCAN1;L3MBTL1;JMJD6;UBQLN4;ORAI1;GSTM3;CPT1A |
| protein binding | MGARP;GNA12;CD84;KCTD17;PAK2;HIST1H2AK;ADAR;CFL2;CXCR2 |
| transcription factor activity, sequence-specific DNA binding | FOXO1B;HOXB5B;FOXO3;JUNBA;NR1D4A;POU3F2B;PBX1B;SIM1B;FOXN1 |
RCAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCAN1.
PRKACB
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