RNF4

  • Official Full Name

    ring finger protein 4
  • Synonyms

    RNF4;ring finger protein 4;SLX5;SNURF;RES4-26;E3 ubiquitin-protein ligase RNF4;E3 ubiquitin ligase RNF4;small nuclear RING finger protein;EC=6.3.2;Protein SNURF;002938

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • GST
  • Avi
  • Fc

    Involved Pathway

    RNF4 involved in several pathways and played different roles in them. We selected most pathways RNF4 participated on our site, such as Adaptive Immune System,Androgen receptor signaling pathway,Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    presentation ERAP2,UBE2V1,CTSL1,TRIM11,SEC23A,STUB1,B2ML,ASB3,KLHL20,FCGR1B
    DNA Repair TDP2B,BARD1,RHNO1,TCEA1,KDM4A,USP43,INO80E,RNF168,DNA2,DDB2
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) PPP4R2B,WRN,RHNO1,PPP4CB,RAD9,HUS1,TOPBP1,PPP4CA,RTEL1,PPP4R2
    Class I MHC mediated antigen processing &amp CYBA,CTSS,UBE2J2,KLHL20,ASB13,CTSL1,SPSB2,BLMH,LRRC41,RNF138
    DNA Double-Strand Break Repair THRSP,RNF168,HUS1,DNA2,BABAM1,PPP4CB,BRE,RAD9,RAD9B,BARD1
    Homology Directed Repair PPP4R2,PPP4R2A,WRN,TIMELESS,KIAA0146,RHNO1,PPP4CA,PPP4CB,TOPBP1,RAD51AP1
    Proteasome degradation TRIM9,LRSAM1,NPEPPS,STUB1,RNF111,TRIM69,FBXO3,FBXO44,TRIM11,UBE2F
    Adaptive Immune System ASB7,KIF2C,ITK,PVRL2L,AP1S1,RNF34,SEC24A,CD300LG,ASB8,UBE2J2
    Antigen processing: Ubiquitination &amp UBA5,TRIM11,RNF25,LRRC41,SPSB1,TRAF7,FBXO44,LTN1,UBR1,ASB13

    Protein Function

    RNF4 has several biochemical functions, for example, DNA binding,SUMO polymer binding,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF4 itself. We selected most functions RNF4 had, and list some proteins which have the same functions with RNF4. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity DTX3,RFFL,TRIM2,MARCH11,TRIM21,MKRN3,EGR2,TTC3,RFWD2,BIRC7
    ubiquitin-protein transferase activity FBXO22,PRP19,RNF144AA,BIRC5,ANAPC4,UBR4,TRIM36,PDZRN3,RCHY1,UBE3C
    nucleosome binding L3MBTL1,ARID1A,RNF168,MUM1,NOC2L,DNTTIP1,HP1BP3,ZNHIT1,SMARCA5,RNF169
    ubiquitin protein ligase activity RNF121,ITCHA,UBE2NB,CDC34,UBE2W,UBE2N,MGRN1,RNF2,UBE2H,UBE3B
    DNA binding LUC7L3,OTPB,MXTX1,TIGD5,TAL2,GM239,NR0B1,KLF7,TBX2B,HIST1H2AI
    transcription factor activity, sequence-specific DNA binding TULP4,ATF7A,NFE2L1A,NR1I3,HOXB4,POU3F2A,TA,FOXD1,ZBTB48,ZNF484
    SUMO polymer binding RNF222,RNF111,SIMC1,SOBP
    transcription coactivator activity MAK,HINFP,SOX10,TAF6L,KDM5A,CARM1,MAGED1,EDF1,RARA,PARK7
    protein binding FABP5,ERC1,RNPS1,SNCG,AGXT,EPHA10,PSMD10,SIGLEC5,LMLN,RSL24D1

    Interacting Protein

    RNF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF4.

    UBE2I;TRPS1;PARP1;UBA1;UBE2N;SRPK2;UBE2V1;NFATC2IP;HIP2;SKIL;UBE2D1;UBE2E1;UBE2D3;UBE2H;UBE2D2;cdsA

    Resources

    References

    • Hendriks, IA; Treffers, LW; et al. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. CELL REPORTS 10:1778-1791(2015).
    • Pagadala, NS; Perez-Pineiro, R; et al. In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 91:118-131(2015).

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