RNF4

  • Official Full Name

    ring finger protein 4
  • Synonyms

    RNF4;ring finger protein 4;SLX5;SNURF;RES4-26;E3 ubiquitin-protein ligase RNF4;E3 ubiquitin ligase RNF4;small nuclear RING finger protein;EC=6.3.2;Protein SNURF;002938

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • GST
  • Avi
  • Fc

    Involved Pathway

    RNF4 involved in several pathways and played different roles in them. We selected most pathways RNF4 participated on our site, such as Adaptive Immune System,Androgen receptor signaling pathway,Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Androgen receptor signaling pathway CTNNB2,NCOA2,NR0B2A,RAD54L2,POU2F1B,SMARCE1,CCDC102A,PARK7,JUN,KAT5
    presentation FBXO17,ASB13,KLHL21,RNF144B,ASB7,RBCK1,CMTM2A,UBE2J2,CD207,SPSB1
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) PPP4R2B,EME1,RAD51AP1,TIMELESS,RTEL1,HUS1,WRN,KIAA0146,RBBP8,PPP4R2A
    DNA Double-Strand Break Repair RAD50,RNF168,UBE2V2,EME2,POLD3,TIPIN,CHEK1,RHNO1,CHEK2,RAD1
    Proteasome degradation TRIM11,ASB18,TRIM39,ASB2,HUWE1,UCHL3,BLMH,UBE2L6,SPSB2,UBE2F
    Homology Directed Repair PPP4R2B,TOPBP1,EME1,PPP4R2,RHNO1,EME2,RAD51AP1,PPP4R2A,TIMELESS,RTEL1
    DNA Repair RNF111,ZBTB32,UBE2V2,PPP4CB,CHD1L,RAD9,TIMELESS,MCRS1,TFPT,RBBP8
    Adaptive Immune System TRIM41,CD300C,CLTC,DYNC1I2,FRS2A,ERAP2,CXADR,FGF18B,DCTN1,KIF3C
    Class I MHC mediated antigen processing &amp ASB13,TRIM41,RNF220,UBE2V2,ATG7,RNF34,B2ML,GAN,UBE2U,ASB6

    Protein Function

    RNF4 has several biochemical functions, for example, DNA binding,SUMO polymer binding,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF4 itself. We selected most functions RNF4 had, and list some proteins which have the same functions with RNF4. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-protein transferase activity PDZRN3,RAG1,XIAP,FEM1B,PDZRN3B,TRIM21,MGRN1,FBXO7,UBE2A,RNF144AA
    transcription coactivator activity TAF5L,GMEB2,E4F1,THRAP3,SETD3,SMARCA4,VGLL1,MED13,MED7,ING4
    ubiquitin protein ligase activity RNF115,MED24,SMURF2,TRIM11,UBE2S,XIAP,HECTD1,DZIP3,ZSWIM2,UBE2J1
    zinc ion binding KDM2B,ZDHHC18A,PPARDB,CPM,UBR1,CPDB,CXXC4,TRIM50,PGLYRP1,LMO7A
    SUMO polymer binding RNF111,RNF222,SIMC1,SOBP
    protein binding HDC,TFAP4,RHNO1,FOS,KITLG,ST8SIA5,FAH,MSH4,HNRNPR,SAP30L
    androgen receptor binding FHL2,PRPF6,PARK7,RB1,GRIP1,RAN,WIPI1,FOXH1,RNF14,KDM3A
    DNA binding HNF1BB,PDCD2,TLR8,LASS5,NAT14,DBX1A,HIST1H3G,ZNF791,LIG1,ARNTL2
    identical protein binding BCHE,DCP1A,PTS,SOD1,RALYL,BRI3,SLK,IAPP,DRD2,IK

    Interacting Protein

    RNF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF4.

    UBE2I;TRPS1;PARP1;UBA1;UBE2N;SRPK2;UBE2V1;NFATC2IP;HIP2;SKIL;UBE2D1;UBE2E1;UBE2D3;UBE2H;UBE2D2;cdsA

    Resources

    References

    • Hendriks, IA; Treffers, LW; et al. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. CELL REPORTS 10:1778-1791(2015).
    • Pagadala, NS; Perez-Pineiro, R; et al. In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 91:118-131(2015).

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